THU123 Knockout Of Renal Glut2 Gene Activates The Hypothalamic-pituitary-adrenal Axis To Increase Glucose Production In Mice
Faniyan T, Robles J, Zhang X, Bathina S, Brookes P, Perry R, Chhabra K. THU123 Knockout Of Renal Glut2 Gene Activates The Hypothalamic-pituitary-adrenal Axis To Increase Glucose Production In Mice. Journal Of The Endocrine Society 2023, 7: bvad114.1201. PMCID: PMC10554224, DOI: 10.1210/jendso/bvad114.1201.Peer-Reviewed Original ResearchKnockout miceAdrenocorticotrophic hormoneHPA axisEndogenous glucose productionCorticotropin-releasing hormone geneSystemic glucose homeostasisHypothalamic-pituitary-adrenal (HPA) axisStreptozocin-induced diabetesCirculating adrenocorticotrophic hormoneGlucose homeostasisElevated blood glucose levelsGlucose productionGLUT2 geneFluorescence in situ hybridizationEfficacy of drugsRegulating systemic glucose homeostasisHigh-fat dietBlood glucose levelsHypothalamic CRHRenal glucose productionAdrenal glandExcess blood glucoseLoss of glucoseMouse modelGlucose tolerance