2024
A practical magnetic-resonance imaging score for outcome prediction in comatose cardiac arrest survivors
Chan W, Nguyen C, Kim N, Tripodis Y, Gilmore E, Greer D, Beekman R. A practical magnetic-resonance imaging score for outcome prediction in comatose cardiac arrest survivors. Resuscitation 2024, 202: 110370. PMID: 39178939, DOI: 10.1016/j.resuscitation.2024.110370.Peer-Reviewed Original ResearchHypoxic-ischemic brain injuryDeep gray nucleiArea under the receiver operating curveMagnetic resonance imagingMagnetic Resonance Imaging ScorePoor neurological outcomeCerebral Performance CategoryIntra-class correlationNeurological outcomeMRI scoreCardiac arrestComatose CA survivorsCA survivorsComatose cardiac arrest survivorsPredicting neurologic outcomeCardiac arrest survivorsInter-rater reliabilityReceiver operating curveAcademic medical centerMedian timePoor outcomePrognostic toolGray nucleiArrest survivorsScore group
2023
Temperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions
Beekman R, Khosla A, Buckley R, Honiden S, Gilmore E. Temperature Control in the Era of Personalized Medicine: Knowledge Gaps, Research Priorities, and Future Directions. Journal Of Intensive Care Medicine 2023, 39: 611-622. PMID: 37787185, DOI: 10.1177/08850666231203596.Peer-Reviewed Original ResearchHypoxic-ischemic brain injuryCardiac arrestPopulation-based thresholdsDuration of therapyCardiac arrest survivorsCause of deathRobust preclinical evidencePatient-centered careCritical future stepNeurologic outcomeNeuroprotective therapiesPreclinical evidenceArrest survivorsClinical equipoiseBrain injuryCurrent guidelinesFever preventionIndividualized targetOnly interventionTherapeutic windowInsufficient evidenceResearch prioritiesPersonalized approachMetabolic demandsCore temperature
2022
Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest
Beekman R, Crawford A, Mazurek MH, Prabhat AM, Chavva IR, Parasuram N, Kim N, Kim JA, Petersen N, de Havenon A, Khosla A, Honiden S, Miller PE, Wira C, Daley J, Payabvash S, Greer DM, Gilmore EJ, Kimberly W, Sheth KN. Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest. Resuscitation 2022, 176: 150-158. PMID: 35562094, PMCID: PMC9746653, DOI: 10.1016/j.resuscitation.2022.05.002.Peer-Reviewed Original ResearchConceptsCardiac arrestBrain injuryHypoxic-ischemic brain injuryAdverse neurological outcomesIschemic brain injurySingle-center studyBrain magnetic resonanceBrain injury severityBoard-certified neuroradiologistsLow-field MRIFLAIR signal intensityNeurological outcomeCA patientsIll patientsMRI findingsCA survivorsCenter studyMRI examinationsClinical careHigh riskInjury severityPatientsSignal intensityBedside monitoringMR imaging
2021
Neuromonitoring After Cardiac Arrest Can Twenty-First Century Medicine Personalize Post Cardiac Arrest Care?
Beekman R, Maciel CB, Balu R, Greer DM, Gilmore EJ. Neuromonitoring After Cardiac Arrest Can Twenty-First Century Medicine Personalize Post Cardiac Arrest Care? Neurologic Clinics 2021, 39: 273-292. PMID: 33896519, DOI: 10.1016/j.ncl.2021.01.002.Peer-Reviewed Original ResearchConceptsSecondary brain injuryCardiac arrest careBrain injuryArrest carePost-cardiac arrest syndromeHypoxic-ischemic brain injuryPost-cardiac arrest careEtiology of arrestSecondary neurologic injuryCardiac arrest survivorsNeurologic comorbiditiesNeuromonitoring toolsNeurologic injuryArrest survivorsCardiac arrestNeuromonitoring techniquesCerebral physiologyPhysiologic variablesIndividualized approachRisk profileInjuryHeterogeneous populationCareArrestComorbidities