Allelic diversity in the merozoite surface protein-1 and epidemiology of multiple-clone Plasmodium falciparum infections in northern Tanzania.
Ferreira M, Liu Q, Kimura M, Ndawi B, Tanabe K, Kawamoto F. Allelic diversity in the merozoite surface protein-1 and epidemiology of multiple-clone Plasmodium falciparum infections in northern Tanzania. Journal Of Parasitology 1998, 84: 1286-9. PMID: 9920333, DOI: 10.2307/3284693.Peer-Reviewed Original ResearchConceptsMerozoite surface protein 1MSP-1 gene typesSurface protein 1Type-specific polymerase chain reactionMajor malaria vaccine candidatePlasmodium falciparum infectionProtein 1Malaria vaccine candidateMsp-1 geneP. falciparum populationsMost patientsFalciparum infectionPolymerase chain reactionDistinct parasite populationsVaccine candidatesClinical isolatesAllelic typesGene typesPlasmodium falciparumNorthern TanzaniaChain reactionPatientsEpidemiological consequencesRecent findingsParasite populationsAllelic Diversity at the Merozoite Surface Protein-1 (MSP-1) Locus in Natural Plasmodium falciparum Populations: a Brief Overview
Ferreira M, Kaneko O, Kimura M, Liu Q, Kawamoto F, Tanabe K. Allelic Diversity at the Merozoite Surface Protein-1 (MSP-1) Locus in Natural Plasmodium falciparum Populations: a Brief Overview. Memórias Do Instituto Oswaldo Cruz 1998, 93: 631-638. PMID: 9830530, DOI: 10.1590/s0074-02761998000500013.Peer-Reviewed Original ResearchConceptsMSP-1 gene typesProtein-1 locusMerozoite surface protein-1 locusNon-random associationGene typesAllelic diversityParasite populationsAllelic typesSingle-copy geneFrequency-dependent immune selectionNatural Plasmodium falciparum populationsMsp-1 locusLocal parasite populationMsp-1 allelic typesDifferent gene typesPlasmodium falciparum populationsVariable blocks 2Wild isolatesSelective pressureSouthwestern Brazilian AmazonExtensive polymorphismLociHuman hostMajor malaria vaccine candidateImmune selection