2023
A novel defined pyroptosis-related gene signature predicts prognosis and correlates with the tumour immune microenvironment in lung adenocarcinoma
Chen Z, Ge L, Xu S, Li Q, Zhou L. A novel defined pyroptosis-related gene signature predicts prognosis and correlates with the tumour immune microenvironment in lung adenocarcinoma. Scientific Reports 2023, 13: 9921. PMID: 37337018, PMCID: PMC10279685, DOI: 10.1038/s41598-023-36720-1.Peer-Reviewed Original ResearchConceptsPyroptosis-related genesTumor-infiltrating immune cellsTumor mutational burdenLung adenocarcinomaImmune cellsMutational burdenPrognostic signaturePyroptosis-related gene signatureTumor microenvironmentGene Expression Omnibus (GEO) cohortSelection operator CoxImmune cell infiltrationRole of pyroptosisIndependent prognostic biomarkerTumor immune microenvironmentCox regression modelImmune checkpoint regulatorsCancer-related deathCancer Genome Atlas (TCGA) databaseSpearman correlation analysisFuture studiesImmune microenvironmentCell infiltrationLUAD patientsCommon causeIntegrated analysis of competitive endogenous RNA networks in elder patients with non-small cell lung cancer
Chen Z, Yu F, Zhu B, Li Q, Yu Y, Zong F, Liu W, Zhang M, Wu S. Integrated analysis of competitive endogenous RNA networks in elder patients with non-small cell lung cancer. Medicine 2023, 102: e33192. PMID: 36897674, PMCID: PMC9997791, DOI: 10.1097/md.0000000000033192.Peer-Reviewed Original ResearchConceptsMRNA ceRNA networkEndogenous RNA (ceRNA) networkCeRNA networkMessenger RNAsRNA networkLncRNA-miRNACompetitive endogenous RNA (ceRNA) networkLong non-coding RNAsPotential ceRNA networksNon-coding RNAsFunctions of DEmRNAsCancer-related processesCancer Genome AtlasGenome analysisGene OntologyKyoto EncyclopediaDevelopment of NSCLCGene Expression Omnibus (GEO) cohortNovel insightsGenome AtlasSurvival packageExpression levelsIntegrated analysisDEmRNAsMiRNAs
2022
A systematic study on 33 gallbladder stones resembling adult Clonorchis sinensis worms
Ma R, Wang X, Li Q, Cai H, Luo X. A systematic study on 33 gallbladder stones resembling adult Clonorchis sinensis worms. Journal Of Helminthology 2022, 96: e90. PMID: 36573372, DOI: 10.1017/s0022149x22000773.Peer-Reviewed Original Research
2021
An update: the emerging evidence of complement involvement in COVID-19
Li Q, Chen Z. An update: the emerging evidence of complement involvement in COVID-19. Medical Microbiology And Immunology 2021, 210: 101-109. PMID: 33811541, PMCID: PMC8019074, DOI: 10.1007/s00430-021-00704-7.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeCOVID-19 patientsCOVID-19Pre-clinical samplesRespiratory distress syndromePotential treatment optionCoronavirus disease 2019Host immune responseMultiorgan failureComplement involvementSystemic inflammationDistress syndromeSevere patientsOrgan damageKidney failureTreatment optionsInflammatory responseTissue injuryDisease 2019Immune responseAnimal modelsMultiple organsAbnormal activationInnate immunityComplement inhibitorsLong noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state
Omote N, Sakamoto K, Li Q, Schupp JC, Adams T, Ahangari F, Chioccioli M, DeIuliis G, Hashimoto N, Hasegawa Y, Kaminski N. Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state. Physiological Reports 2021, 9: e14727. PMID: 33527707, PMCID: PMC7851438, DOI: 10.14814/phy2.14727.Peer-Reviewed Original ResearchConceptsTerminal differentiation-induced lncRNANormal human bronchial epithelial cellsTINCR overexpressionCell differentiationNotch genesTissue developmentBronchial epithelial cellsExtracellular matrix organizationCell phenotypeRNA sequencing analysisNumerous biological functionsRole of lncRNAsCell differentiation stateEpithelial cellsHuman bronchial epithelial cellsCiliated cell differentiationStaufen1 proteinNovel regulatorBasal cell phenotypeDownstream regulatorsRNA immunoprecipitationBiological functionsCritical regulatorDifferential expressionDifferentiation state
2020
Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy
Liu W, Deacon J, Yan H, Sun B, Liu Y, Hegan D, Li Q, Coman D, Parent M, Hyder F, Roberts K, Nath R, Tillement O, Engelman D, Glazer P. Tumor-targeted pH-low insertion peptide delivery of theranostic gadolinium nanoparticles for image-guided nanoparticle-enhanced radiation therapy. Translational Oncology 2020, 13: 100839. PMID: 32763504, PMCID: PMC7408331, DOI: 10.1016/j.tranon.2020.100839.Peer-Reviewed Original ResearchHuman lung cancer cellsA549 human lung cancer cellsMolecular MRI techniqueTumor-bearing miceLung cancer cellsClonogenic survival assaysVivo radiosensitizationRadiation therapySolid tumorsTumor cell metabolismTumorsEnhanced radiosensitivityTumor cellsMR imagingSurvival assaysMRI techniquesCancer cellsTreatment planningRadiotherapyTumor coreGeneral hallmarkRadiotherapy treatment planningRadiosensitivityPeptide deliveryDeliveryCorrection to: A pooled analysis of the LAMP assay for the detection of Neisseria meningitidis
Fan SJ, Tan HK, Xu YC, Chen YZ, Xie TA, Pan ZY, Ouyang S, Li Q, Li XY, Li ZX, Guo XG. Correction to: A pooled analysis of the LAMP assay for the detection of Neisseria meningitidis. BMC Infectious Diseases 2020, 20: 560. PMID: 32736603, PMCID: PMC7395387, DOI: 10.1186/s12879-020-05300-3.Peer-Reviewed Original ResearchA pooled analysis of the LAMP assay for the detection of Neisseria meningitidis
Fan SJ, Tan HK, Xu YC, Chen YZ, Xie TA, Pan ZY, Ouyang S, Li Q, Li XY, Li ZX, Guo XG. A pooled analysis of the LAMP assay for the detection of Neisseria meningitidis. BMC Infectious Diseases 2020, 20: 525. PMID: 32689953, PMCID: PMC7372874, DOI: 10.1186/s12879-020-05250-w.Peer-Reviewed Original ResearchConceptsLoop-mediated isothermal amplificationBacterial meningitisFunnel plotPublication biasHigh mortality rateLAMP assayWeb of ScienceSROC curvePooled analysisMortality rateClinical practiceDiagnostic accuracyMajor causeMeningococcusNeisseria meningitidisSummary receiverCharacteristic curveMeningitisReliable diagnosisDeeks' funnel plotIsothermal amplificationDepressed areasOriginal studyMeningitidisBacterial culturePooled analysis of the Xpert MTB/RIF assay for diagnosing tuberculous meningitis
Chen YZ, Sun LC, Wen YH, Li ZW, Fan SJ, Tan HK, Qiu M, Pan ZY, Li Q, Zhao YZ, Li ZX, Guo XG. Pooled analysis of the Xpert MTB/RIF assay for diagnosing tuberculous meningitis. Bioscience Reports 2020, 40: bsr20191312. PMID: 31778149, PMCID: PMC6946622, DOI: 10.1042/bsr20191312.Peer-Reviewed Original ResearchConceptsXpert MTB/RIFMTB/RIFTuberculous meningitisPositive likelihood ratioNegative likelihood ratioDiagnostic odds ratioOdds ratioEarly diagnosisCerebrospinal fluidCSF samplesPooled sensitivityLikelihood ratioReceiver operator characteristic curveOverall pooled sensitivityOperator characteristic curveExtrapulmonary tuberculosisDiagnostic delayPooled analysisSummary receiver operator characteristic curveDiagnostic efficacyClinical diagnosisMeningitisPooled specificityRelevant studiesDiagnosis
2019
Transcriptional regulatory model of fibrosis progression in the human lung
McDonough JE, Ahangari F, Li Q, Jain S, Verleden SE, Herazo-Maya J, Vukmirovic M, DeIuliis G, Tzouvelekis A, Tanabe N, Chu F, Yan X, Verschakelen J, Homer RJ, Manatakis DV, Zhang J, Ding J, Maes K, De Sadeleer L, Vos R, Neyrinck A, Benos PV, Bar-Joseph Z, Tantin D, Hogg JC, Vanaudenaerde BM, Wuyts WA, Kaminski N. Transcriptional regulatory model of fibrosis progression in the human lung. JCI Insight 2019, 4 PMID: 31600171, PMCID: PMC6948862, DOI: 10.1172/jci.insight.131597.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisAdvanced fibrosisAlveolar surface densityFibrosis progressionLung fibrosisHuman lungDynamic Regulatory Events MinerExtent of fibrosisIPF lungsPulmonary fibrosisControl lungsIPF tissueB lymphocytesFibrosisLungLinear mixed-effects modelsMixed-effects modelsGene expression changesSystems biology modelsDifferential gene expression analysisGene expression analysisProgressionGene expression networksRNA sequencingBiology models
2011
Distinct polyfunctional CD4+ T cell responses to BCG, ESAT-6 and CFP-10 in tuberculous pleurisy
Li L, Qiao D, Li Q, Zhang X, Lao S, Wu C. Distinct polyfunctional CD4+ T cell responses to BCG, ESAT-6 and CFP-10 in tuberculous pleurisy. Tuberculosis 2011, 92: 63-71. PMID: 22154006, DOI: 10.1016/j.tube.2011.11.004.Peer-Reviewed Original ResearchConceptsPleural fluid cellsESAT-6T cellsMedian fluorescence intensityTuberculous pleurisyCFP-10IL-2Effector/effector memory phenotypeAntigen-specific T cellsFrequent extrapulmonary manifestationMtb-specific antigensEffector memory phenotypeT cell responsesCFP-10 peptidesExtrapulmonary manifestationsPolyfunctional CD4Th1 cytokinesTuberculosis infectionMemory phenotypeInflammatory cellsTh1 cellsSpecific antigenLocal controlCell responsesFollowing StimulationB lymphocytes that migrate to tuberculous pleural fluid via the SDF‐1/CXCR4 axis actively respond to antigens specific for Mycobacterium tuberculosis
Feng L, Li L, Liu Y, Qiao D, Li Q, Fu X, Wang H, Lao S, Wu C. B lymphocytes that migrate to tuberculous pleural fluid via the SDF‐1/CXCR4 axis actively respond to antigens specific for Mycobacterium tuberculosis. European Journal Of Immunology 2011, 41: 3261-3269. PMID: 21818756, DOI: 10.1002/eji.201141625.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntigens, BacterialB-Lymphocyte SubsetsB-LymphocytesCell SeparationChemokine CXCL12Chemotaxis, LeukocyteEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryHumansLymphocyte ActivationMaleMiddle AgedMycobacterium tuberculosisReceptors, CXCR4Signal TransductionTuberculosis, PleuralYoung AdultConceptsSDF-1/CXCR4 axisStromal cell-derived factor-1SDF-1 levelsPleural fluidB cellsPeripheral bloodTuberculous pleuritisCXCR4 axisCell-derived factor-1Early secretory antigenic targetTuberculous pleural fluidMemory B cellsESAT-6 proteinField of tuberculosisB cell biologyTP patientsAntigenic targetsImmune responsePleural spaceB lymphocytesProtein 10TuberculosisM. tuberculosisMycobacterium tuberculosisMore antibodiesHuman natural killer cells expressing the memory‐associated marker CD45RO from tuberculous pleurisy respond more strongly and rapidly than CD45RO− natural killer cells following stimulation with interleukin‐12
Fu X, Liu Y, Li L, Li Q, Qiao D, Wang H, Lao S, Fan Y, Wu C. Human natural killer cells expressing the memory‐associated marker CD45RO from tuberculous pleurisy respond more strongly and rapidly than CD45RO− natural killer cells following stimulation with interleukin‐12. Immunology 2011, 134: 41-49. PMID: 21711347, PMCID: PMC3173693, DOI: 10.1111/j.1365-2567.2011.03464.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntigens, CDAntigens, Differentiation, T-LymphocyteCD56 AntigenCell CountCytotoxicity, ImmunologicFemaleGPI-Linked ProteinsGranzymesHumansInterferon-gammaInterleukin-12Interleukin-2 Receptor alpha SubunitK562 CellsKiller Cells, NaturalLectins, C-TypeLeukocyte Common AntigensLeukocytes, MononuclearLymphocyte ActivationLymphocyte SubsetsMaleMiddle AgedNK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily KPleural EffusionReceptors, IgGReceptors, Interleukin-12Tuberculosis, PleuralYoung AdultConceptsPleural fluid cellsNatural killer cellsNK cellsKiller cellsInterleukin-12Human natural killer cellsAdaptive immune featuresCD45RO- NK cellsInnate immune lymphocytesHuman NK cellsIL-12 receptor β1Immune lymphocytesIL-12Tuberculous patientsTuberculous pleurisyImmune featuresGranzyme BMore interferonReceptor β1Mycobacterium tuberculosisCD45ROFluid cellsPresent studyCellsCD25Biological functions of Mycobacterium tuberculosis-specific CD4+T cells were impaired by tuberculosis pleural fluid
Li Q, Li L, Liu Y, Fu X, Wang H, Lao S, yang B, Wu C. Biological functions of Mycobacterium tuberculosis-specific CD4+T cells were impaired by tuberculosis pleural fluid. Immunology Letters 2011, 138: 113-121. PMID: 21549757, DOI: 10.1016/j.imlet.2011.03.008.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAmino Acid SequenceAntibodies, NeutralizingAntigens, BacterialBacterial ProteinsBody FluidsCD4-Positive T-LymphocytesCells, CulturedFemaleHumansInterferon-gammaInterleukin-10Interleukin-2LungLymphocyte ActivationMaleMiddle AgedMolecular Sequence DataMonocytesMycobacterium tuberculosisTransforming Growth Factor betaTuberculosis, PleuralTumor Necrosis Factor-alphaConceptsPleural fluid mononuclear cellsPleural fluidAntigen-specific cellular immune responsesFluid mononuclear cellsIFN-γ productionMycobacterium tuberculosis infectionCellular immune responsesProduction of IFNT cell functionDose-dependent mannerTuberculosis patientsIL-10Tuberculosis infectionTuberculosis pleurisyCytokine productionMononuclear cellsIL-2Activation moleculeImmune responseCell activation processCFSE labelingCell activationFunctional predominanceCell activityStrong inhibitory effectPleural fluid from tuberculous pleurisy inhibits the functions of T cells and the differentiation of Th1 cells via immunosuppressive factors
Li Q, Li L, Liu Y, Fu X, Qiao D, Wang H, Lao S, Huang F, Wu C. Pleural fluid from tuberculous pleurisy inhibits the functions of T cells and the differentiation of Th1 cells via immunosuppressive factors. Cellular & Molecular Immunology 2011, 8: 172-180. PMID: 21258363, PMCID: PMC4003141, DOI: 10.1038/cmi.2010.80.Peer-Reviewed Original ResearchConceptsT cell functionT cellsIL-10Tuberculosis pleurisyTh1 cellsLocal immune statusCourse of diseaseTumor necrosis factorTh1 cell differentiationGrowth factor-β1Inhibitor of indoleamineImmunosuppressive mediatorsEffect of PFImmunosuppressive factorsCytokine productionImmune statusTuberculous pleurisyPleural fluidImmunopathological factorsFactor-β1Cell activationPleurisyGrowth factorCell cycle progressionCycle progression[Analysis of ESAT-6-specific multifunctional CD4+; T cells in pleural fluid from patients with tuberculous pleurisy].
Li L, Qiao D, Li Q, Zhang X, Lao S, Wu C. [Analysis of ESAT-6-specific multifunctional CD4+; T cells in pleural fluid from patients with tuberculous pleurisy]. Chinese Journal Of Cellular And Molecular Immunology 2011, 27: 26-8. PMID: 21208559.Peer-Reviewed Original ResearchConceptsRecombinant ESAT-6 proteinT cellsESAT-6 proteinCytokine productionMean fluorescence intensityPeptide poolsTB infectionIL-2Positive cellsTh1 cytokine productionSingle-positive cellsTriple-positive cellsTuberculous pleurisyESAT-6Cell levelSingle-cell levelFlow cytometrySimilar frequencyStimulationCytokinesIFNTNFInfectionBCGCells