2021
Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state
Omote N, Sakamoto K, Li Q, Schupp JC, Adams T, Ahangari F, Chioccioli M, DeIuliis G, Hashimoto N, Hasegawa Y, Kaminski N. Long noncoding RNA TINCR is a novel regulator of human bronchial epithelial cell differentiation state. Physiological Reports 2021, 9: e14727. PMID: 33527707, PMCID: PMC7851438, DOI: 10.14814/phy2.14727.Peer-Reviewed Original ResearchConceptsTerminal differentiation-induced lncRNANormal human bronchial epithelial cellsTINCR overexpressionCell differentiationNotch genesTissue developmentBronchial epithelial cellsExtracellular matrix organizationCell phenotypeRNA sequencing analysisNumerous biological functionsRole of lncRNAsCell differentiation stateEpithelial cellsHuman bronchial epithelial cellsCiliated cell differentiationStaufen1 proteinNovel regulatorBasal cell phenotypeDownstream regulatorsRNA immunoprecipitationBiological functionsCritical regulatorDifferential expressionDifferentiation state
2011
B lymphocytes that migrate to tuberculous pleural fluid via the SDF‐1/CXCR4 axis actively respond to antigens specific for Mycobacterium tuberculosis
Feng L, Li L, Liu Y, Qiao D, Li Q, Fu X, Wang H, Lao S, Wu C. B lymphocytes that migrate to tuberculous pleural fluid via the SDF‐1/CXCR4 axis actively respond to antigens specific for Mycobacterium tuberculosis. European Journal Of Immunology 2011, 41: 3261-3269. PMID: 21818756, DOI: 10.1002/eji.201141625.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntigens, BacterialB-Lymphocyte SubsetsB-LymphocytesCell SeparationChemokine CXCL12Chemotaxis, LeukocyteEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryHumansLymphocyte ActivationMaleMiddle AgedMycobacterium tuberculosisReceptors, CXCR4Signal TransductionTuberculosis, PleuralYoung AdultConceptsSDF-1/CXCR4 axisStromal cell-derived factor-1SDF-1 levelsPleural fluidB cellsPeripheral bloodTuberculous pleuritisCXCR4 axisCell-derived factor-1Early secretory antigenic targetTuberculous pleural fluidMemory B cellsESAT-6 proteinField of tuberculosisB cell biologyTP patientsAntigenic targetsImmune responsePleural spaceB lymphocytesProtein 10TuberculosisM. tuberculosisMycobacterium tuberculosisMore antibodiesPleural fluid from tuberculous pleurisy inhibits the functions of T cells and the differentiation of Th1 cells via immunosuppressive factors
Li Q, Li L, Liu Y, Fu X, Qiao D, Wang H, Lao S, Huang F, Wu C. Pleural fluid from tuberculous pleurisy inhibits the functions of T cells and the differentiation of Th1 cells via immunosuppressive factors. Cellular & Molecular Immunology 2011, 8: 172-180. PMID: 21258363, PMCID: PMC4003141, DOI: 10.1038/cmi.2010.80.Peer-Reviewed Original ResearchConceptsT cell functionT cellsIL-10Tuberculosis pleurisyTh1 cellsLocal immune statusCourse of diseaseTumor necrosis factorTh1 cell differentiationGrowth factor-β1Inhibitor of indoleamineImmunosuppressive mediatorsEffect of PFImmunosuppressive factorsCytokine productionImmune statusTuberculous pleurisyPleural fluidImmunopathological factorsFactor-β1Cell activationPleurisyGrowth factorCell cycle progressionCycle progression