Human natural killer cells expressing the memory‐associated marker CD45RO from tuberculous pleurisy respond more strongly and rapidly than CD45RO− natural killer cells following stimulation with interleukin‐12
Fu X, Liu Y, Li L, Li Q, Qiao D, Wang H, Lao S, Fan Y, Wu C. Human natural killer cells expressing the memory‐associated marker CD45RO from tuberculous pleurisy respond more strongly and rapidly than CD45RO− natural killer cells following stimulation with interleukin‐12. Immunology 2011, 134: 41-49. PMID: 21711347, PMCID: PMC3173693, DOI: 10.1111/j.1365-2567.2011.03464.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntigens, CDAntigens, Differentiation, T-LymphocyteCD56 AntigenCell CountCytotoxicity, ImmunologicFemaleGPI-Linked ProteinsGranzymesHumansInterferon-gammaInterleukin-12Interleukin-2 Receptor alpha SubunitK562 CellsKiller Cells, NaturalLectins, C-TypeLeukocyte Common AntigensLeukocytes, MononuclearLymphocyte ActivationLymphocyte SubsetsMaleMiddle AgedNK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily KPleural EffusionReceptors, IgGReceptors, Interleukin-12Tuberculosis, PleuralYoung AdultConceptsPleural fluid cellsNatural killer cellsNK cellsKiller cellsInterleukin-12Human natural killer cellsAdaptive immune featuresCD45RO- NK cellsInnate immune lymphocytesHuman NK cellsIL-12 receptor β1Immune lymphocytesIL-12Tuberculous patientsTuberculous pleurisyImmune featuresGranzyme BMore interferonReceptor β1Mycobacterium tuberculosisCD45ROFluid cellsPresent studyCellsCD25[Analysis of ESAT-6-specific multifunctional CD4+; T cells in pleural fluid from patients with tuberculous pleurisy].
Li L, Qiao D, Li Q, Zhang X, Lao S, Wu C. [Analysis of ESAT-6-specific multifunctional CD4+; T cells in pleural fluid from patients with tuberculous pleurisy]. Chinese Journal Of Cellular And Molecular Immunology 2011, 27: 26-8. PMID: 21208559.Peer-Reviewed Original ResearchConceptsRecombinant ESAT-6 proteinT cellsESAT-6 proteinCytokine productionMean fluorescence intensityPeptide poolsTB infectionIL-2Positive cellsTh1 cytokine productionSingle-positive cellsTriple-positive cellsTuberculous pleurisyESAT-6Cell levelSingle-cell levelFlow cytometrySimilar frequencyStimulationCytokinesIFNTNFInfectionBCGCells