2019
Transcriptional regulatory model of fibrosis progression in the human lung
McDonough JE, Ahangari F, Li Q, Jain S, Verleden SE, Herazo-Maya J, Vukmirovic M, DeIuliis G, Tzouvelekis A, Tanabe N, Chu F, Yan X, Verschakelen J, Homer RJ, Manatakis DV, Zhang J, Ding J, Maes K, De Sadeleer L, Vos R, Neyrinck A, Benos PV, Bar-Joseph Z, Tantin D, Hogg JC, Vanaudenaerde BM, Wuyts WA, Kaminski N. Transcriptional regulatory model of fibrosis progression in the human lung. JCI Insight 2019, 4 PMID: 31600171, PMCID: PMC6948862, DOI: 10.1172/jci.insight.131597.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisAdvanced fibrosisAlveolar surface densityFibrosis progressionLung fibrosisHuman lungDynamic Regulatory Events MinerExtent of fibrosisIPF lungsPulmonary fibrosisControl lungsIPF tissueB lymphocytesFibrosisLungLinear mixed-effects modelsMixed-effects modelsGene expression changesSystems biology modelsDifferential gene expression analysisGene expression analysisProgressionGene expression networksRNA sequencingBiology models
2011
B lymphocytes that migrate to tuberculous pleural fluid via the SDF‐1/CXCR4 axis actively respond to antigens specific for Mycobacterium tuberculosis
Feng L, Li L, Liu Y, Qiao D, Li Q, Fu X, Wang H, Lao S, Wu C. B lymphocytes that migrate to tuberculous pleural fluid via the SDF‐1/CXCR4 axis actively respond to antigens specific for Mycobacterium tuberculosis. European Journal Of Immunology 2011, 41: 3261-3269. PMID: 21818756, DOI: 10.1002/eji.201141625.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntigens, BacterialB-Lymphocyte SubsetsB-LymphocytesCell SeparationChemokine CXCL12Chemotaxis, LeukocyteEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryHumansLymphocyte ActivationMaleMiddle AgedMycobacterium tuberculosisReceptors, CXCR4Signal TransductionTuberculosis, PleuralYoung AdultConceptsSDF-1/CXCR4 axisStromal cell-derived factor-1SDF-1 levelsPleural fluidB cellsPeripheral bloodTuberculous pleuritisCXCR4 axisCell-derived factor-1Early secretory antigenic targetTuberculous pleural fluidMemory B cellsESAT-6 proteinField of tuberculosisB cell biologyTP patientsAntigenic targetsImmune responsePleural spaceB lymphocytesProtein 10TuberculosisM. tuberculosisMycobacterium tuberculosisMore antibodies