2024
Clinical Effectiveness of Genetic Testing Guidelines in Patients with Thoracic Aortic Aneurysms
Erez E, Acuna Higaki A, Cupo M, Phu T, Verma S, Assi R, Vallabhajosyula P. Clinical Effectiveness of Genetic Testing Guidelines in Patients with Thoracic Aortic Aneurysms. Journal Of Thoracic And Cardiovascular Surgery 2024 PMID: 39321868, DOI: 10.1016/j.jtcvs.2024.09.026.Peer-Reviewed Original ResearchFeatures of connective tissue diseaseThoracic aortic diseaseConnective tissue diseaseThoracic aortic aneurysmGenetic testing guidelinesSyndromic featuresMutation rateFamily historyVUS rateAortic aneurysmPrimary genesGenetic testingAssociated with thoracic aortic diseaseThoracic aorta diameterTesting guidelinesAorta diameterPathogen mutation rateAortic diseaseRisk stratificationSecondary genesPathogenic mutationsTissue diseaseClinical effectsVUSGenesRisk Scores (Risk Stratification)
Singh S, Vallabhajosyula P. Risk Scores (Risk Stratification). 2024, 50-55. DOI: 10.1201/9781003384779-6.Peer-Reviewed Original ResearchAge is just a number: Complex hybrid arch repair in a nonagenarian
Hameed I, Ahmed A, Vallabhajosyula P. Age is just a number: Complex hybrid arch repair in a nonagenarian. Canadian Journal Of Cardiology 2024 PMID: 39033813, DOI: 10.1016/j.cjca.2024.07.013.Peer-Reviewed Original ResearchThe role of hybrid arch repair with thoracic endovascular repair for contemporary management of complex arch and descending thoracoabdominal aortopathies
Ahmed A, Hameed I, Vallabhajosyula P. The role of hybrid arch repair with thoracic endovascular repair for contemporary management of complex arch and descending thoracoabdominal aortopathies. Journal Of Clinical Anesthesia And Intensive Care 2024, 4: 6-7. DOI: 10.46439/anesthesia.4.019.Peer-Reviewed Original ResearchThoracic endovascular aneurysm repair of a ruptured zone 0 mycotic thoracic aortic aneurysm
Kostiuk V, Vallabhajosyula P, Nassiri N, Tonnessen B. Thoracic endovascular aneurysm repair of a ruptured zone 0 mycotic thoracic aortic aneurysm. Annals Of Vascular Surgery - Brief Reports And Innovations 2024, 4: 100302. DOI: 10.1016/j.avsurg.2024.100302.Peer-Reviewed Original ResearchThoracic endovascular aneurysm repairEndovascular aneurysm repairAneurysm repairAcute type B aortic dissectionAcute onset chest painWeeks of antibiotic treatmentType B aortic dissectionAnti-impulse therapyExclusion of hemorrhageOnset chest painAortic arch debranchingPost-operative courseB aortic dissectionComputed tomography angiogramThoracic aortic aneurysmZone 0 TEVARArch debranchingMediastinal infectionChest painContrast extravasationBack painAntibiotic treatmentAortic aneurysmPost-operativelyFollow-upPeripheral Blood Extracellular Vesicle RNA Profiling: The Next Step in Cancer Liquid Biopsies
Hu R, Korutla L, Vallabhajosyula P. Peripheral Blood Extracellular Vesicle RNA Profiling: The Next Step in Cancer Liquid Biopsies. Annals Of Surgical Oncology 2024, 31: 4179-4181. PMID: 38755337, DOI: 10.1245/s10434-024-15400-y.Peer-Reviewed Original ResearchEfficacy and Safety of Botulinum Toxin Type A for the Prevention of Postoperative Atrial Fibrillation
Piccini J, Ahlsson A, Dorian P, Gillinov A, Kowey P, Mack M, Milano C, Noiseux N, Perrault L, Ryan W, Steinberg J, Voisine P, Waldron N, Gleason K, Titanji W, Leaback R, O’Sullivan A, Ferguson W, Benussi S, Investigators N, Akhter S, Andreas M, Benussi S, Castella M, Dalrymple-Hay M, El-Eshmawi A, Groh M, Hanke T, Jeanmart H, Katz M, McCullough J, Melby S, Miller J, Noiseux N, Romano M, Perrault L, Piccini J, Podgoreanu M, Ryan W, Sharma V, Shults C, Teman N, Voisine P, Whitson B, Wickbom A, Vallabhajosyula P, Yau T. Efficacy and Safety of Botulinum Toxin Type A for the Prevention of Postoperative Atrial Fibrillation. JACC Clinical Electrophysiology 2024, 10: 930-940. PMID: 38661602, DOI: 10.1016/j.jacep.2024.01.020.Peer-Reviewed Original ResearchPrevention of postoperative atrial fibrillationPostoperative atrial fibrillationCoronary artery bypass graftingRate of postoperative atrial fibrillationSafety of botulinum toxin type ACardiac surgeryPrimary endpointBotulinum toxin type AToxin type AAtrial fibrillationAssociated with increased morbidityRate of adverse eventsDose-ranging studyPlacebo-controlled trialOpen-chest cardiac surgeryType of surgeryEpicardial fat padsInjection of botulinum toxinArtery bypass graftingRandomized clinical trialsPlacebo-ControlledValve surgeryDouble-blindPlacebo groupContinuous AFIntimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis
Hassab A, Hur D, Vallabhajosyula P, Tellides G, Assi R. Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis. JCI Insight 2024, 9: e172437. PMID: 38592807, PMCID: PMC11141924, DOI: 10.1172/jci.insight.172437.Peer-Reviewed Original ResearchConceptsDepartment of SurgerySmooth muscle cellsCellular response to injuryResponse to injuryImmunofluorescence confocal microscopyVessel wall repairPrimary lesionAscending aortaConduit functionAneurysmal diseaseDense fibrosisRadiological signsMural hematomaTear progressionMuscle cellsNon-hemorrhagicErythrocyte extravasationWall repairAortaTear completionInduce atherosclerosisHealed lesionsScattered leukocytesMinimal injuryConclusionThese findingsLiving in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis
Ram C, Yousef S, Ma W, Vallabhajosyula I, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Williams M, Geirsson A, Vallabhajosyula P. Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis. Scientific Reports 2024, 14: 4952. PMID: 38418864, PMCID: PMC10902341, DOI: 10.1038/s41598-024-52660-w.Peer-Reviewed Original ResearchConceptsAortic valve replacementSevere aortic stenosisAfrican American raceArea Deprivation IndexAortic stenosisSevere ASArea deprivation index rankAortic valve replacement ratesAmerican raceAortic valve interventionPresentation of sepsisDiagnosis of ASADI groupValve replacementValve interventionDeprived neighbourhoodsAV interventionDisadvantaged neighborhoodsPatientsFemale genderDeprivation indexHigh-ADI groupLow-ADI groupStenosisRaceBicuspid Aortic Valve: Current Therapeutic Strategies
Usman Bin Mahmood S, Vallabhajosyula P, Milewski R. Bicuspid Aortic Valve: Current Therapeutic Strategies. 2024, 1 DOI: 10.5772/intechopen.113315.Peer-Reviewed Original ResearchBicuspid aortic valveAortic valveTherapeutic strategiesValve-sparing root reimplantationBicuspid aortic valve patientsBAV syndromeSurgical therapeutic strategiesAortic valve replacementAortic valve patientsAortic valve stenosisAortic valve repairLong-term outcomesCurrent therapeutic strategiesBAV populationAorta replacementBentall procedureValve patientsValve replacementValve stenosisRoot reimplantationValve repairValvular pathologySurgical proceduresGeneral populationIndividualized approachContributors to Volume 2
Abouljoud M, Abu-Gazala S, Akbulut S, Al Harakeh H, Aleassa E, Alqahtani S, Ascher N, Asolati M, Aucejo F, Bababekov Y, Baker T, Barth R, Bayer J, Benedetti E, Benedetti C, Bhati C, Bizzaro D, Bond G, Braun H, Broelsch C, Broering D, Bromberg J, Brown R, Brucker S, Bui J, Burra P, Cagliani J, Carr-Boyd P, Cascalho M, Cattral M, Chan S, Chen C, Cherqui D, Ciria R, Crane A, Cravedi P, Kwon C, de Magnee C, Delmonico F, De Prisco G, Di Bella C, Di Cocco P, di Sabato D, Diaz G, Dudkowski M, Eagle E, Eisenson D, Emond J, Emre S, Ericzon B, Florman S, Freise C, Fronek J, Fung J, Furian L, Ganoza A, Genedy L, Giacomo G, Giglio M, Gorrell D, Gruessner R, Gruessner A, Hashimoto K, Heffron N, Heffron T, Heimbach J, Hester J, Hibi T, Hirao H, Humar A, Hwang S, Iesari S, Ince V, Isik B, Issa F, Jacobs C, Järvholm S, Jeon H, Johannesson L, Kalis A, Kaplan A, Khan K, Khanna A, Kim K, Kim W, Kittle H, Knechtle S, Koppe S, Kord A, Kristek J, Kumar S, Kupiec-Weglinski J, Lake J, LaMattina J, Lee S, Lerut J, Lin T, Bianco E, Lo C, Malago M, Malik S, Maluf D, Marique L, Martin D, Mazariegos G, Mazariegos G, McCallion O, McGraw L, Meier R, Merola J, Miller C, Moon D, Moore H, Muller Y, Nadalin S, Nada A, Nakamura K, Ogle B, Ogura Y, Olausson M, Olthoff K, Ong A, Paci P, Piedrahita J, Pinna A, Pirotte T, Pita A, Platt J, Pomfret E, Pomposelli J, Quintini C, Reding R, Renz J, Rizzari M, Roberts J, Roggen F, Roll G, Sachs D, Salerno D, Samstein B, Schmitz R, Selzner N, Senzolo M, Sonmez T, Stock P, Tabrizian P, Tambucci R, Tanaka K, Testa G, Thaker S, Thomson M, Tranäng M, Troisi R, Tulla K, Tully M, Tumeh J, Tzvetanov I, Umman V, Unver U, Vallabhajosyula P, Wahid N, Wilczek H, Williams N, Xie J, Yamada K, Yilmaz S, Zanetto A, Zaza G, Zeytunlu M. Contributors to Volume 2. 2024, xiii-xviii. DOI: 10.1016/b978-0-443-23571-9.01004-5.Peer-Reviewed Original Research
2023
Aortic remodeling following hybrid arch repair with zone 0 to 5 thoracic endovascular aortic repairs for complex arch and descending thoracic aortic pathologies
Hameed I, Ahmed A, Pupovac S, Nassiri N, Assi R, Vallabhajosyula P. Aortic remodeling following hybrid arch repair with zone 0 to 5 thoracic endovascular aortic repairs for complex arch and descending thoracic aortic pathologies. JTCVS Open 2023, 17: 23-36. PMID: 38420535, PMCID: PMC10897673, DOI: 10.1016/j.xjon.2023.12.004.Peer-Reviewed Original ResearchHybrid aortic arch repairThoracic endovascular repairAortic arch repairAortic remodelingArch repairLuminal diameterZone 0Complete false lumen thrombosisLeft inferior pulmonary veinThoracic endovascular aortic repairComputed tomography angiography scansFalse lumen obliterationInferior left atriumFalse lumen thrombosisHigh-risk patientsHybrid arch repairAortic arch pathologiesCommon iliac arteryEndovascular aortic repairAdjunctive treatment strategyInferior pulmonary veinShort-term outcomesThoracic aortic pathologyTomography angiography scansAorta remodelingCirculating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection
Korutla L, Hoffman J, Rostami S, Hu R, Korutla V, Markmann C, Mullan C, Sotolongo A, Habertheuer A, Romano C, Acker M, Sen S, Agarwal D, Jayaraman A, Li B, Davis M, Naji A, Vallabhajosyula P. Circulating T cell specific extracellular vesicle profiles in cardiac allograft acute cellular rejection. American Journal Of Transplantation 2023, 24: 419-435. PMID: 38295008, DOI: 10.1016/j.ajt.2023.10.021.Peer-Reviewed Original ResearchAcute cellular rejectionAllogeneic transplant recipientsTransplant recipientsCellular rejectionHeart transplantationAlloreactive T cell activationEarly acute cellular rejectionT-cell receptor sequencingSyngeneic transplant recipientsCell receptor sequencingClinical heart transplantationT cell clonesNovel candidate biomarkersT cell activationQuantitative RT-PCRRecipient circulationOrgan transplantationT cellsVesicle profilesNoninvasive biomarkersCandidate biomarkersCell activationRegulatory markersDonor cardiomyocytesTransplantationOne-Year Results of a Low-Profile Endograft in Acute, Complicated Type B Aortic Dissection
Rossi P, Desai N, Malaisrie S, Lyden S, Nassiri N, Reece T, Adams J, Moanie S, Shults C, Investigators R, Vallabhajosyula P, Panneton J, Kumins N, Sharafuddin M, Toursavadkohi S, Ullery B, Duwayri Y, Han S, Rahimi S, Meisner R, Dryjski M, Starnes B, Fukuhara S, Cheema M. One-Year Results of a Low-Profile Endograft in Acute, Complicated Type B Aortic Dissection. The Annals Of Thoracic Surgery 2023, 117: 336-343. PMID: 37769702, DOI: 10.1016/j.athoracsur.2023.08.035.Peer-Reviewed Original ResearchConceptsType B aortic dissectionComplicated type B aortic dissectionMajor adverse eventsB aortic dissectionAdverse eventsCause mortalityAortic dissectionTechnical successEnd pointAortic diameter growthFalse lumen perfusionPrimary end pointSecondary end pointsKaplan-Meier analysisOne-year resultsParaplegia/paraparesisLong-term outcomesUnited States CentersMedian hospitalizationAortic expansionPatency lossRenal failurePivotal trialsRetrograde dissectionIliac arteryAortic Remodeling Following Hybrid Arch Repair for Complex Arch and Proximal Descending Thoracic Aortopathies
Hameed I, Ahmed A, Pupovac S, Komlo C, Amabile A, Nassiri N, Assi R, Vallabhajosyula P. Aortic Remodeling Following Hybrid Arch Repair for Complex Arch and Proximal Descending Thoracic Aortopathies. Journal Of Vascular Surgery 2023, 77: e255-e256. DOI: 10.1016/j.jvs.2023.03.361.Peer-Reviewed Original Research
2018
Management of Patients With Coronary Artery Malperfusion Secondary to Type A Aortic Dissection
Kreibich M, Bavaria JE, Branchetti E, Brown CR, Chen Z, Khurshan F, Siki M, Vallabhajosyula P, Szeto WY, Desai ND. Management of Patients With Coronary Artery Malperfusion Secondary to Type A Aortic Dissection. The Annals Of Thoracic Surgery 2018, 107: 1174-1180. PMID: 30444990, DOI: 10.1016/j.athoracsur.2018.09.065.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortic Aneurysm, ThoracicAortic DissectionBlood Vessel Prosthesis ImplantationCohort StudiesCoronary Artery BypassCoronary Artery DiseaseCoronary CirculationFemaleGermanyHeart Arrest, InducedHospital MortalityHospitals, UniversityHumansKaplan-Meier EstimateLength of StayMaleMiddle AgedPostoperative ComplicationsPrognosisRetrospective StudiesRisk AssessmentStatistics, NonparametricSurvival AnalysisTreatment OutcomeConceptsCoronary artery malperfusionType B patientsType C patientsAntegrade cardioplegiaC patientsB patientsAortic dissectionCoronary ostiumDissection flapCA diseaseA Aortic DissectionType C lesionsManagement of patientsType B lesionsLong-term survivalCA bypassBypass GraftingPerioperative mortalityC lesionsComplete avulsionB lesionsLandmark analysisMalperfusionSuture repairPatientsFunctional Outcomes of Type I Bicuspid Aortic Valve Repair With Annular Stabilization: Subcommissural Annuloplasty Versus External Subannular Aortic Ring
Ko H, Bavaria JE, Habertheuer A, Augoustides JG, Siki MA, Freas M, Komlo C, Milewski K, Desai ND, Szeto WY, Vallabhajosyula P. Functional Outcomes of Type I Bicuspid Aortic Valve Repair With Annular Stabilization: Subcommissural Annuloplasty Versus External Subannular Aortic Ring. The Annals Of Thoracic Surgery 2018, 107: 68-75. PMID: 30086284, DOI: 10.1016/j.athoracsur.2018.06.056.Peer-Reviewed Original ResearchConceptsSubcommissural annuloplastyAortic insufficiencyAortic valve repairTransvalvular gradientValve repairAortic ringsLeaflet prolapseAnnular stabilizationVentricular outflow tract diameterBicuspid aortic valve patientsBicuspid aortic valve repairOutflow tract diameterSevere aortic insufficiencyMean transvalvular gradientIntraoperative transesophageal echocardiographyAortic valve patientsLV outflow tractAortic root complexPostprocedure outcomesValve patientsTract diameterFunctional outcomeLV dimensionsTransesophageal echocardiographyOutflow tractPredictors of Recurrent Aortic Insufficiency in Type I Bicuspid Aortic Valve Repair
Habertheuer A, Milewski RK, Bavaria JE, Siki M, Freas M, Desai N, Szeto W, Ram C, Hu R, Vallabhajosyula P. Predictors of Recurrent Aortic Insufficiency in Type I Bicuspid Aortic Valve Repair. The Annals Of Thoracic Surgery 2018, 106: 1316-1324. PMID: 30055138, DOI: 10.1016/j.athoracsur.2018.06.026.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAgedAortic ValveAortic Valve InsufficiencyBicuspid Aortic Valve DiseaseCardiac Valve AnnuloplastyDatabases, FactualFemaleFollow-Up StudiesHeart Valve DiseasesHeart Valve ProsthesisHumansLogistic ModelsMaleMiddle AgedPredictive Value of TestsRecurrenceReoperationRetrospective StudiesRisk AssessmentSurvival RateTreatment OutcomeDistinct macrophage populations direct inflammatory versus physiological changes in adipose tissue
Hill DA, Lim HW, Kim YH, Ho WY, Foong YH, Nelson VL, Nguyen HCB, Chegireddy K, Kim J, Habertheuer A, Vallabhajosyula P, Kambayashi T, Won KJ, Lazar MA. Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e5096-e5105. PMID: 29760084, PMCID: PMC5984532, DOI: 10.1073/pnas.1802611115.Peer-Reviewed Original ResearchConceptsMultiple distinct populationsUnique tissue distributionTissue macrophage subsetsChromatin landscapeDistinct macrophage populationsTranscriptional mechanismsGene programObese fat tissueGene expressionDistinct populationsFunctional differencesAdipocyte physiologyCrown-like structuresAdipose tissueMacrophage populationsFunctional heterogeneityATM populationsTissue distributionHuman adipose tissueMacrophage subsetsPhysiological changesFat cellsAdoptive transferBody massTranscriptomeSimplifying aortic arch surgery: open zone 2 arch with single branched thoracic endovascular aortic repair completion.
Desai ND, Hoedt A, Wang G, Szeto WY, Vallabhajosyula P, Reinke M, Bavaria JE. Simplifying aortic arch surgery: open zone 2 arch with single branched thoracic endovascular aortic repair completion. Annals Of Cardiothoracic Surgery 2018, 7: 351-356. PMID: 30155413, PMCID: PMC6094018, DOI: 10.21037/acs.2018.05.08.Peer-Reviewed Original Research