Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue
Hill DA, Lim HW, Kim YH, Ho WY, Foong YH, Nelson VL, Nguyen HCB, Chegireddy K, Kim J, Habertheuer A, Vallabhajosyula P, Kambayashi T, Won KJ, Lazar MA. Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e5096-e5105. PMID: 29760084, PMCID: PMC5984532, DOI: 10.1073/pnas.1802611115.Peer-Reviewed Original ResearchConceptsMultiple distinct populationsUnique tissue distributionTissue macrophage subsetsChromatin landscapeDistinct macrophage populationsTranscriptional mechanismsGene programObese fat tissueGene expressionDistinct populationsFunctional differencesAdipocyte physiologyCrown-like structuresAdipose tissueMacrophage populationsFunctional heterogeneityATM populationsTissue distributionHuman adipose tissueMacrophage subsetsPhysiological changesFat cellsAdoptive transferBody massTranscriptome