2024
Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis
Ram C, Yousef S, Ma W, Vallabhajosyula I, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Williams M, Geirsson A, Vallabhajosyula P. Living in disadvantaged neighborhoods linked to less intervention for severe aortic stenosis. Scientific Reports 2024, 14: 4952. PMID: 38418864, PMCID: PMC10902341, DOI: 10.1038/s41598-024-52660-w.Peer-Reviewed Original ResearchConceptsAortic valve replacementSevere aortic stenosisAfrican American raceArea Deprivation IndexAortic stenosisSevere ASArea deprivation index rankAortic valve replacement ratesAmerican raceAortic valve interventionPresentation of sepsisDiagnosis of ASADI groupValve replacementValve interventionDeprived neighbourhoodsAV interventionDisadvantaged neighborhoodsPatientsFemale genderDeprivation indexHigh-ADI groupLow-ADI groupStenosisRaceBicuspid Aortic Valve: Current Therapeutic Strategies
Usman Bin Mahmood S, Vallabhajosyula P, Milewski R. Bicuspid Aortic Valve: Current Therapeutic Strategies. 2024, 1 DOI: 10.5772/intechopen.113315.Peer-Reviewed Original ResearchBicuspid aortic valveAortic valveTherapeutic strategiesValve-sparing root reimplantationBicuspid aortic valve patientsBAV syndromeSurgical therapeutic strategiesAortic valve replacementAortic valve patientsAortic valve stenosisAortic valve repairLong-term outcomesCurrent therapeutic strategiesBAV populationAorta replacementBentall procedureValve patientsValve replacementValve stenosisRoot reimplantationValve repairValvular pathologySurgical proceduresGeneral populationIndividualized approach
2018
Hemodynamic Effects of Valve Asymmetry in Sapien 3 Transcatheter Aortic Valves.
Mangels DR, Siki M, Menon R, Bavaria J, Anwaruddin S, Giri J, Desai N, Szeto WY, Vallabhajosyula P, Herrmann HC. Hemodynamic Effects of Valve Asymmetry in Sapien 3 Transcatheter Aortic Valves. Journal Of Invasive Cardiology 2018, 30: 138-143. PMID: 29610444.Peer-Reviewed Original ResearchConceptsStructural valve deteriorationTranscatheter aortic valve replacementSAPIEN 3 valveParavalvular leakTransthoracic echocardiogramAortic insufficiencySAPIEN 3 transcatheter aortic valveAortic valve gradientSapien 3 prosthesisAortic valve replacementRetrospective cohort analysisTranscatheter aortic valveAI severityValve gradientAnnular calcificationHemodynamic effectsValve replacementValve deteriorationSmall prosthesisSingle institutionAortic valveAV gradientCohort analysisHigh incidenceSignificant differencesAssociation of Tricuspid Regurgitation With Transcatheter Aortic Valve Replacement Outcomes: A Report From The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry
McCarthy FH, Vemulapalli S, Li Z, Thourani V, Matsouaka RA, Desai ND, Kirtane A, Anwaruddin S, Williams ML, Giri J, Vallabhajosyula P, Li RH, Herrmann HC, Bavaria JE, Szeto WY. Association of Tricuspid Regurgitation With Transcatheter Aortic Valve Replacement Outcomes: A Report From The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry. The Annals Of Thoracic Surgery 2018, 105: 1121-1128. PMID: 29502934, DOI: 10.1016/j.athoracsur.2017.11.018.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementHeart failure readmissionCardiology Transcatheter Valve Therapy RegistryThoracic Surgeons/American CollegeTranscatheter Valve Therapy RegistrySevere TRVentricular ejection fractionTricuspid regurgitationMild TRRisk patientsEjection fractionTR severityAmerican CollegeEffectiveness of TAVRInhospital major adverse cardiac eventsTranscatheter Aortic Valve Replacement OutcomesModerate TRMajor adverse cardiac eventsTricuspid regurgitation severityAdverse cardiac eventsAortic valve replacementHigh-risk patientsLow-risk patientsNumber of comorbiditiesIntensive care unit
2017
Management of coronary obstruction following transcatheter aortic valve replacement
Sultan I, Siki M, Wallen T, Szeto W, Vallabhajosyula P. Management of coronary obstruction following transcatheter aortic valve replacement. Journal Of Cardiac Surgery 2017, 32: 777-781. PMID: 29143378, DOI: 10.1111/jocs.13252.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementValve replacementCoronary arterySelf-expanding transcatheter aortic valve replacementLeft coronary arteryTAVR casesCoronary ostiumCoronary obstructionHigh riskMortality rateComplicationsArteryOcclusionPreventionManagementReplacementOstiumObstructionMortalityIncidenceConscious Sedation Versus General Anesthesia for Transcatheter Aortic Valve Replacement
Hyman MC, Vemulapalli S, Szeto WY, Stebbins A, Patel PA, Matsouaka RA, Herrmann HC, Anwaruddin S, Kobayashi T, Desai ND, Vallabhajosyula P, McCarthy FH, Li R, Bavaria JE, Giri J. Conscious Sedation Versus General Anesthesia for Transcatheter Aortic Valve Replacement. Circulation 2017, 136: 2132-2140. PMID: 28864443, DOI: 10.1161/circulationaha.116.026656.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnesthesia, GeneralAortic Valve StenosisComparative Effectiveness ResearchConscious SedationFemaleHospital MortalityHumansIntention to Treat AnalysisLength of StayMalePatient DischargePractice Patterns, Physicians'RegistriesRisk AssessmentRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsTranscatheter aortic valve replacementAortic valve replacementConscious sedationIntensive care unitGeneral anesthesiaHospital lengthValve replacementProcedural successCare unitEnd-point analysisPercutaneous transfemoral transcatheter aortic valve replacementConscious Sedation Versus General AnesthesiaTransfemoral transcatheter aortic valve replacementCardiology Transcatheter Valve Therapy RegistryThoracic Surgeons/American CollegeDeath/stroke ratePacemaker/defibrillator implantationTranscatheter Valve Therapy RegistryInverse probabilityConscious sedation groupDeath/strokeTreatment-weighted adjustmentTreatment-weighted analysisLower procedural successComparative effectiveness analysisStroke After Transcatheter Aortic Valve Replacement: Incidence, Definitions, Etiologies and Management Options
Patel PA, Patel S, Feinman JW, Gutsche JT, Vallabhajosyula P, Shah R, Giri J, Desai ND, Zhou E, Weiss SJ, Augoustides JG. Stroke After Transcatheter Aortic Valve Replacement: Incidence, Definitions, Etiologies and Management Options. Journal Of Cardiothoracic And Vascular Anesthesia 2017, 32: 968-981. PMID: 29174745, DOI: 10.1053/j.jvca.2017.08.034.Peer-Reviewed Educational MaterialsConceptsTranscatheter aortic valve replacementAortic valve replacementValve replacementEtiology of strokeEmbolic protection devicesCardiovascular clinical trialsPerioperative pathwayNeurologic complicationsNeurologic eventsNeurologic injuryClinical trialsInvestigational approachesCardiovascular interventionsStrokeEtiologyTriphasic approachManagement optionsComplicationsThrombosisReplacementInjuryNovel guidelinesIncidenceDiagnosisTrialsOutcomes of Elective Aortic Hemiarch Reconstruction for Aneurysmal Disease in the Elderly
Kilic A, Arnaoutakis GJ, Bavaria JE, Sultan I, Desai ND, Vallabhajosyula P, Williams ML, Milewski RK, Szeto WY. Outcomes of Elective Aortic Hemiarch Reconstruction for Aneurysmal Disease in the Elderly. The Annals Of Thoracic Surgery 2017, 104: 1522-1530. PMID: 28648536, DOI: 10.1016/j.athoracsur.2017.03.067.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overAorta, ThoracicAortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationCirculatory Arrest, Deep Hypothermia InducedCohort StudiesElective Surgical ProceduresFemaleGeriatric AssessmentHospital MortalityHumansMaleMiddle AgedPlastic Surgery ProceduresPostoperative CarePostoperative ComplicationsPrognosisPropensity ScoreRegistriesRetrospective StudiesRisk AssessmentSex FactorsSurvival AnalysisTreatment OutcomeConceptsModerate hypothermic circulatory arrestAntegrade cerebral perfusionHypothermic circulatory arrestHemiarch reconstructionElderly patientsAneurysmal diseaseOperative mortalityCerebral perfusionCirculatory arrestConcomitant aortic valve replacementRisk-adjusted operative mortalityCoronary artery bypassOperative mortality rateAortic valve replacementGreater comorbidity burdenLow operative mortalityOverall stroke rateSafe strategyIntensive care unitComorbidity burdenArtery bypassHospital stayRoot replacementValve replacementCare unitFate of remnant sinuses of Valsalva in patients with bicuspid and trileaflet valves undergoing aortic valve, ascending aorta, and aortic arch replacement
Milewski RK, Habertheuer A, Bavaria JE, Siki M, Szeto WY, Krause E, Korutla V, Desai ND, Vallabhajosyula P. Fate of remnant sinuses of Valsalva in patients with bicuspid and trileaflet valves undergoing aortic valve, ascending aorta, and aortic arch replacement. Journal Of Thoracic And Cardiovascular Surgery 2017, 154: 421-432. PMID: 28599977, DOI: 10.1016/j.jtcvs.2017.03.150.Peer-Reviewed Original ResearchConceptsAortic valve replacementBicuspid aortic valveAorta replacementTricuspid aortic valveValve replacementAortic valveValsalva dimensionsPreoperative sinusSinus segmentValvular morphologyValvular pathologyElective aortic valve replacementMultivariable Cox regression modelsAortic arch replacementKaplan-Meier analysisAortic valve morphologyCox regression modelAortic valvulopathyArch replacementSurgical managementAortic aneurysmAortic rootLongitudinal sinusValsalva groupPatients
2016
Valve Selection in End-Stage Renal Disease: Should It Always Be Biological?
Williams ML, Bavaria JE, Acker MA, Desai ND, Vallabhajosyula P, Hargrove WC, Atluri P, Szeto WY. Valve Selection in End-Stage Renal Disease: Should It Always Be Biological? The Annals Of Thoracic Surgery 2016, 102: 1531-1535. PMID: 27544289, DOI: 10.1016/j.athoracsur.2016.04.092.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAnticoagulantsAortic ValveBioprosthesisCalcinosisContraindicationsEndocarditisHeart Valve DiseasesHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansKaplan-Meier EstimateKidney Failure, ChronicMiddle AgedMitral ValvePostoperative ComplicationsProportional Hazards ModelsProsthesis-Related InfectionsRenal DialysisRetrospective StudiesThrombophiliaConceptsEnd-stage renal diseaseValve replacementProportional hazards modelESRD patientsMechanical valvesRenal diseaseHazards modelImproved long-term survivalCox proportional hazards modelAortic valve replacementMechanical valve replacementMitral valve replacementKaplan-Meier methodLong-term survivalValve selectionESRD populationPatient ageUnadjusted survivalImproved survivalPatient populationPatientsSurvivalDiseaseMinimal differencesYearsNew Ventricular Septal Defects Following Balloon-Expandable Transcatheter Aortic Valve Replacement.
Rene AG, Jagasia D, Wickramasinghe SR, Desai N, Szeto W, Vallabhajosyula P, Li RH, Silvestry FE, Giri J, Jha S, Herrmann HC, Anwaruddin S. New Ventricular Septal Defects Following Balloon-Expandable Transcatheter Aortic Valve Replacement. Journal Of Invasive Cardiology 2016, 28: e59-65. PMID: 27342207.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAortic ValveAortic Valve StenosisEchocardiographyFemaleHeart Septal Defects, VentricularHumansMaleOutcome and Process Assessment, Health CarePostoperative ComplicationsQuality of LifeReoperationRisk AssessmentRisk FactorsSeverity of Illness IndexTranscatheter Aortic Valve ReplacementConceptsTranscatheter aortic valve replacementLeft ventricular outflow tract calcificationSevere symptomatic aortic stenosisVentricular outflow tract calcificationSymptomatic aortic stenosisAortic valve replacementVentricular septal defectNew ventricular septal defectQuality of lifeInoperable patientsInfrequent complicationParavalvular regurgitationValve replacementAortic stenosisVascular injurySeptal defectPatientsComplicationsStudied populationRegurgitationStenosisInjuryStrokeCalcification
2015
Direct innominate artery cannulation: An alternate technique for antegrade cerebral perfusion during aortic hemiarch reconstruction
Jassar AS, Vallabhajosyula P, Bavaria JE, Gutsche J, Desai ND, Williams ML, Milewski RK, Hargrove WC, Szeto WY. Direct innominate artery cannulation: An alternate technique for antegrade cerebral perfusion during aortic hemiarch reconstruction. Journal Of Thoracic And Cardiovascular Surgery 2015, 151: 1073-1078. PMID: 26725716, DOI: 10.1016/j.jtcvs.2015.11.027.Peer-Reviewed Original ResearchMeSH KeywordsAgedAorta, ThoracicAortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationBrachiocephalic TrunkCatheterization, PeripheralCerebrovascular CirculationFemaleHeart Arrest, InducedHospital MortalityHumansHypothermia, InducedMaleMiddle AgedPerfusionPostoperative ComplicationsRegional Blood FlowReoperationTime FactorsTreatment OutcomeConceptsAntegrade cerebral perfusionModerate hypothermic circulatory arrestHypothermic circulatory arrestHemiarch reconstructionInnominate arteryCerebral perfusionCirculatory arrestReversible ischemic neurologic deficitExcellent cerebral protectionInnominate artery cannulationIschemic neurologic deficitAortic valve replacementRenal failure rateProximal aortic aneurysmIncidence of injuryACP timeAscending aorticCrossclamp timeArtery cannulationCerebral protectionCentral cannulationNeurologic deficitsPatient ageRoot replacementValve replacementOutcomes of transcatheter aortic valve replacement in patients with chronic liver disease
Shah AM, Ogbara J, Herrmann HC, Fox Z, Kadakia M, Anwaruddin S, Bavaria JE, Desai ND, Jagasia D, Szeto WY, Li RH, Vallabhajosyula P, Giri J. Outcomes of transcatheter aortic valve replacement in patients with chronic liver disease. Catheterization And Cardiovascular Interventions 2015, 86: 888-894. PMID: 25963625, DOI: 10.1002/ccd.25994.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBioprosthesisBiopsyCardiac CatheterizationChronic DiseaseFeasibility StudiesFemaleFemoral ArteryHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHospital MortalityHumansLiver DiseasesMaleMiddle AgedPatient SelectionRetrospective StudiesRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeConceptsTranscatheter aortic valve replacementChronic liver diseaseValve Academic Research ConsortiumAcute kidney injuryAortic valve replacementLiver diseaseLate deathsKidney injuryValve replacementUnknown causeTransapical (TA) TAVRRole of TAVRTA TAVRSevere symptomatic aortic valve stenosisModerate chronic liver diseaseSymptomatic aortic valve stenosisAdvanced liver diseaseMajor bleeding complicationsNon-cardiac causesOutcomes of patientsTransient ischemic attackAcademic Research ConsortiumHigh-risk surgeryAortic valve stenosisLong-term followModerate Versus Deep Hypothermic Circulatory Arrest for Elective Aortic Transverse Hemiarch Reconstruction
Vallabhajosyula P, Jassar AS, Menon RS, Komlo C, Gutsche J, Desai ND, Hargrove WC, Bavaria JE, Szeto WY. Moderate Versus Deep Hypothermic Circulatory Arrest for Elective Aortic Transverse Hemiarch Reconstruction. The Annals Of Thoracic Surgery 2015, 99: 1511-1517. PMID: 25825200, DOI: 10.1016/j.athoracsur.2014.12.067.Peer-Reviewed Original ResearchConceptsModerate hypothermic circulatory arrestDeep hypothermic circulatory arrestHypothermic circulatory arrestDirect innominate artery cannulationAntegrade cerebral perfusionInnominate artery cannulationCerebral perfusionCirculatory arrestHemiarch reconstructionTransfusion requirementsArtery cannulationMHCA groupCerebral perfusion strategyCerebral protection strategiesConcomitant root replacementRetrograde cerebral perfusionAortic valve replacementFresh frozen plasmaAortic aneurysm diseaseHemodialysis rateAortic reconstructionNeurologic complicationsGroup patientsPostoperative outcomesRoot replacement
2014
Aortic and Mitral Valve Replacement Versus Transcatheter Aortic Valve Replacement in Propensity-Matched Patients
McCarthy FH, Desai ND, Herrmann HC, Kobrin D, Vallabhajosyula P, Fox Z, Menon R, Augoustides JG, Giri JS, Anwaruddin S, Li RH, Jagasia DH, Bavaria JE, Szeto WY. Aortic and Mitral Valve Replacement Versus Transcatheter Aortic Valve Replacement in Propensity-Matched Patients. The Annals Of Thoracic Surgery 2014, 98: 1267-1273. PMID: 25149054, DOI: 10.1016/j.athoracsur.2014.05.075.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementSignificant mitral regurgitationMitral regurgitationValve replacementMVR groupTAVR groupMidterm survivalOpen aortic valve replacementEquivalent perioperative outcomesGreater mitral regurgitationPostoperative mitral regurgitationThoracic Surgeons scoreHigh-risk patientsPropensity-matched analysisPropensity-matched pairsPairs of patientsMitral valve repairMVR patientsPreoperative endocarditisPropensity matching techniquesTAVR patientsPerioperative outcomesEjection fractionSurgeons scoreFactors Associated With Vascular Complications in Patients Undergoing Balloon-Expandable Transfemoral Transcatheter Aortic Valve Replacement via Open Versus Percutaneous Approaches
Kadakia MB, Herrmann HC, Desai ND, Fox Z, Ogbara J, Anwaruddin S, Jagasia D, Bavaria JE, Szeto WY, Vallabhajosyula P, Li R, Menon R, Kobrin DM, Giri J. Factors Associated With Vascular Complications in Patients Undergoing Balloon-Expandable Transfemoral Transcatheter Aortic Valve Replacement via Open Versus Percutaneous Approaches. Circulation Cardiovascular Interventions 2014, 7: 570-576. PMID: 25027520, DOI: 10.1161/circinterventions.113.001030.Peer-Reviewed Original ResearchConceptsTransfemoral transcatheter aortic valve replacementTranscatheter aortic valve replacementAortic valve replacementVascular complicationsLength of stayValve replacementOpen surgicalPC groupMultivariable analysisArtery diameterValve Academic Research ConsortiumSheath outer diameterMajor vascular complicationsAcademic Research ConsortiumPropensity-matched analysisPostprocedural lengthPropensity matchingClinical outcomesSignificant morbidityFemale sexPercutaneous approachSimilar riskComplicationsOS groupStayCombined Transaortic Transcatheter Valve Replacement and Thoracic Endografting
Komlo CM, Vallabhajosyula P, Bavaria JE, Desai ND, Anwaruddin S, Giri JS, Herrmann HC, Szeto WY. Combined Transaortic Transcatheter Valve Replacement and Thoracic Endografting. The Annals Of Thoracic Surgery 2014, 97: 696-698. PMID: 24484814, DOI: 10.1016/j.athoracsur.2013.05.099.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementThoracic aortic endovascular repairPercutaneous coronary interventionAortic stenosisValve replacementAortic endovascular repairSevere aortic stenosisAortic valve replacementCritical aortic stenosisCatheter-based treatmentThoracic aortic aneurysmTranscatheter valve replacementPartial sternotomy approachCatheter-based proceduresTAo accessCoronary interventionEndovascular repairTransaortic approachTransfemoral accessSternotomy approachAortic aneurysmThoracic endograftingFirst reportEndograftingStenosis
2012
Percutaneous Closure of a Left Ventricular Pseudoaneurysm After Sapien XT Transapical Transcatheter Aortic Valve Replacement
Bortnick AE, Gordon E, Gutsche J, Anwaruddin S, Szeto WY, Desai N, Vallabhajosyula P, Bavaria JE, Herrmann HC. Percutaneous Closure of a Left Ventricular Pseudoaneurysm After Sapien XT Transapical Transcatheter Aortic Valve Replacement. JACC Cardiovascular Interventions 2012, 5: e37-e38. PMID: 23257383, DOI: 10.1016/j.jcin.2012.08.014.Peer-Reviewed Original Research
2011
Transcatheter aortic valve implantation: complications and management.
Vallabhajosyula P, Bavaria JE. Transcatheter aortic valve implantation: complications and management. The Journal Of Heart Valve Disease 2011, 20: 499-509. PMID: 22066353.Peer-Reviewed Original ResearchMeSH KeywordsAortic AneurysmAortic DissectionAortic Valve StenosisBioprosthesisCardiac CatheterizationCardiopulmonary BypassClinical CompetenceHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansHypotensionIliac ArteryMyocardial IschemiaPatient Care TeamPostoperative ComplicationsProsthesis FittingStrokeConceptsTranscatheter aortic valve implantationAortic valve replacementSerious life-threatening complicationsImmediate cardiopulmonary bypassPoor surgical candidatesSevere aortic stenosisLife-threatening complicationsAortic valve implantationAnnulus injuryCoronary complicationsPerfusion teamTAVI patientsValve malpositionCardiac depressionPericardial effusionSurgical candidatesValve implantationValve replacementAortic stenosisCardiopulmonary bypassSerious complicationsParavalvular leakOptimal careVascular injuryCardiac anesthesia