Common Familial Colorectal Cancer Linked to Chromosome 7q31: A Genome-Wide Analysis
Neklason D, Kerber R, Nilson D, Anton-Culver H, Schwartz A, Griffin C, Lowery J, Schildkraut J, Evans J, Tomlinson G, Strong L, Miller A, Stopfer J, Finkelstein D, Nadkarni P, Kasten C, Mineau G, Burt R. Common Familial Colorectal Cancer Linked to Chromosome 7q31: A Genome-Wide Analysis. Cancer Research 2008, 68: 8993-8997. PMID: 18974144, PMCID: PMC2927856, DOI: 10.1158/0008-5472.can-08-1376.Peer-Reviewed Original ResearchConceptsGenetic regionsLinkage analysisGenome-wide analysisFamilial cancer genesNovel susceptibility genesNonparametric linkage analysisShort tandem repeat markersCommon Familial Colorectal CancerFine mappingRepeat markersTandem repeat markersCancer genesChromosome 7q31Odds (LOD) scoreGenesSusceptibility genesSignificant linkagePenetrant genesDNA samplesFamilial colorectal cancerRelative pairsLociCancer onsetColorectal cancer onsetCancer syndromes