2010
Widespread regulatory activity of vertebrate microRNA* species
Yang J, Phillips M, Betel D, Mu P, Ventura A, Siepel A, Chen K, Lai E. Widespread regulatory activity of vertebrate microRNA* species. RNA 2010, 17: 312-326. PMID: 21177881, PMCID: PMC3022280, DOI: 10.1261/rna.2537911.Peer-Reviewed Original ResearchConceptsAnalysis of microarray dataVertebrate regulatory networksStudy of miRNA functionMiRNA:miRNARelevant to oncogenesisFraction of miRNAsTranscriptome-wide evidenceRegulatory networksMicroarray dataVertebrate evolutionSilencing complexMiRNA functionMiR-19RNA duplexesExpression constructsBioinformatics analysisMature miRNAsStrand speciesVertebratesSpeciesObligate intermediateSensor assayMutagenesis testsRepressionSeed sites
2009
Genetic dissection of the miR-17∼92 cluster of microRNAs in Myc-induced B-cell lymphomas
Mu P, Han Y, Betel D, Yao E, Squatrito M, Ogrodowski P, de Stanchina E, D'Andrea A, Sander C, Ventura A. Genetic dissection of the miR-17∼92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes & Development 2009, 23: 2806-2811. PMID: 20008931, PMCID: PMC2800095, DOI: 10.1101/gad.1872909.Peer-Reviewed Original ResearchConceptsMiR-17MiR-17~92 clusterMiR-19Computational target predictionMiR-19aTranscriptional target of c-MycMiR-19bTarget of c-MycMiR-17~92Cluster of microRNAsMyc-driven B-cell lymphomasConditional knockout alleleMouse model of B-cell lymphomaGene expression profilesGenetic dissectionIndividual miRNAsMiRNAsProsurvival activityTranscriptional targetsTarget predictionModel of B-cell lymphomaC-mycSuppressed apoptosisMicroRNAsExpression profiles