2021
Overcoming oncogene addiction in breast and prostate cancers: a comparative mechanistic overview.
Blatt E, Kopplin N, Kumar S, Mu P, Conzen S, Raj G. Overcoming oncogene addiction in breast and prostate cancers: a comparative mechanistic overview. Endocrine Related Cancer 2021, 28: r31-r46. PMID: 33263560, PMCID: PMC8218927, DOI: 10.1530/erc-20-0272.Peer-Reviewed Original ResearchConceptsProstate cancerHormone-dependent cancersBreast cancerTherapy resistanceAndrogen receptorMechanisms of endocrine therapy resistanceTherapeutic strategiesTherapy-resistant prostate cancerEndocrine therapy resistanceAdvanced prostate cancerTherapy-resistant tumorsNuclear receptorsMechanisms of resistancePotential therapeutic strategyEndocrine therapyMetastatic patientsAntiestrogen resistanceOncogene addictionClinical benefitTumor typesEstrogen receptorFrequent mechanismCancerReceptorsAugmented activity
2020
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer
Zhang Z, Karthaus W, Lee Y, Gao V, Wu C, Russo J, Liu M, Mota J, Abida W, Linton E, Lee E, Barnes S, Chen H, Mao N, Wongvipat J, Choi D, Chen X, Zhao H, Manova-Todorova K, de Stanchina E, Taplin M, Balk S, Rathkopf D, Gopalan A, Carver B, Mu P, Jiang X, Watson P, Sawyers C. Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer. Cancer Cell 2020, 38: 279-296.e9. PMID: 32679108, PMCID: PMC7472556, DOI: 10.1016/j.ccell.2020.06.005.Peer-Reviewed Original ResearchMeSH KeywordsAndrogen AntagonistsAnimalsCancer-Associated FibroblastsCell Line, TumorCell ProliferationCells, CulturedDrug Resistance, NeoplasmGene Expression ProfilingGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMaleMice, SCIDNeuregulin-1Prostatic NeoplasmsTumor MicroenvironmentXenograft Model Antitumor AssaysConceptsCancer-associated fibroblastsProstate cancerAntiandrogen resistanceNeuregulin-1Second-generation antiandrogen therapyResistance to hormonal therapyCastration-resistant prostate cancerTreat advanced prostate cancerProstate organoid culturesSecond-generation antiandrogensAdvanced prostate cancerActivation of HER3Antiandrogen therapyHormone therapyHormone deprivationPharmacological blockadeTargeted therapyParacrine mechanismsTumor cellsMouse modelProstateClinical testingOrganoid culturesTherapyCancer