2016
Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial 1–3
Protiva P, Pendyala S, Nelson C, Augenlicht LH, Lipkin M, Holt PR. Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: a human crossover trial 1–3. American Journal Of Clinical Nutrition 2016, 103: 1224-1231. PMID: 27009752, PMCID: PMC4841933, DOI: 10.3945/ajcn.114.105304.Peer-Reviewed Original ResearchConceptsWestern-style dietCalcium supplementationInflammatory pathwaysImmune responseHuman colorectumAdequate vitamin D statusHigh dietary calcium intakeLower colorectal cancer riskClinical trial evidenceDietary calcium intakePrimary study endpointVitamin D statusColorectal cancer riskUrinary calcium concentrationD statusCalcium intakeUrinary calciumStudy endpointCrossover trialTrial evidenceBiopsy specimensColorectal mucosaTrial protocolColonic mucosaAdaptive immunity
2015
Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men
Clark BT, Protiva P, Nagar A, Imaeda A, Ciarleglio MM, Deng Y, Laine L. Quantification of Adequate Bowel Preparation for Screening or Surveillance Colonoscopy in Men. Gastroenterology 2015, 150: 396-405. PMID: 26439436, PMCID: PMC4728019, DOI: 10.1053/j.gastro.2015.09.041.Peer-Reviewed Original ResearchConceptsAdequate bowel preparationBBPS scoreSurveillance colonoscopyBowel preparationColon segmentsBBPS scoresSecond examinationWest Haven Veterans Affairs Medical CenterVeterans Affairs Medical CenterFirst examinationGuideline-recommended intervalsProspective observational studyDetection of adenomasIdentification of polypsColonoscopic evaluationPrimary outcomeSurveillance intervalsBlinded endoscopistsColonoscopy examinationObservational studyPrEP scaleMedical CenterInitial examinationStudy subjectsAdequate preparationUnder-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity
Hayashi P, Fontana R, Chalasani N, Stolz A, Talwalkar J, Navarro V, Lee W, Davern T, Kleiner D, Gu J, Hoofnagle J, Investigators D, Chalasani N, Vuppalanchi R, Molleston J, Lumeng L, Corne A, Plummer A, Bonkovsky H, Protiva P, Freston J, Rosson R, Levine R, Maliakkal B, Appleton P, Smialek M, Fontana R, Conjeevaram H, Moseley R, Gordon S, Welch S, Worley J, Kridler J, Trivedi S, Kochlar S, Watkins P, Hayashi P, Russo M, Guess H, Beaver K, Smith A, Lewis J, Pusek S, Russell T, Mehltretter L, Davern T, Bonacini M, Partovi K, Fajardo K, Tai S, Lee W, Rockey D, Larson A, Grant L, Landgraf K, Stoltz A, Kaplowitz N, Milstein S, Talwalker J, Johnson S, Navarro V, Reddy R, Vega M, Wirjosemito A, Evans K, Rochon J, McHutchison J, Tilllmann H, Maggio M, Yang H, Galan K, Cosslin E, Sunas L, Collini M, Rose T, Crowder M, Scharenbroich C, Rostami H, Jiezhun S, Monroe T, Hammett A, Rosado N, Serrano J, Seeff L, Hoofnagle J, Toke D, Witt D, Higgins H, Kleiner D, Avigan M, Senior J. Under-reporting and Poor Adherence to Monitoring Guidelines for Severe Cases of Isoniazid Hepatotoxicity. Clinical Gastroenterology And Hepatology 2015, 13: 1676-1682.e1. PMID: 25724701, PMCID: PMC4653068, DOI: 10.1016/j.cgh.2015.02.024.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAdverse Drug Reaction Reporting SystemsAgedAntitubercular AgentsChemical and Drug Induced Liver InjuryChildChild, PreschoolDrug-Related Side Effects and Adverse ReactionsFemaleGuideline AdherenceHealth Services ResearchHumansIsoniazidMaleMiddle AgedProspective StudiesRetrospective StudiesUnited StatesYoung AdultConceptsLiver transplantationATS guidelinesIsoniazid hepatotoxicityLeading causeATS criteriaMeeting criteriaAmerican Thoracic Society guidelinesUnderwent liver transplantationThoracic Society guidelinesSeverity Index scoreCases of hepatotoxicityLatent tuberculosisMedian ageLiver injurySociety guidelinesPoor adherenceSevere outcomesInclusion criteriaSevere casesSevere injuriesIndex scoreHepatotoxicityAbstractTextMonitoring guidelinesPatients
2011
Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury
Davern TJ, Chalasani N, Fontana RJ, Hayashi PH, Protiva P, Kleiner DE, Engle RE, Nguyen H, Emerson SU, Purcell RH, Tillmann HL, Gu J, Serrano J, Hoofnagle JH, Network D. Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury. Gastroenterology 2011, 141: 1665-1672.e9. PMID: 21855518, PMCID: PMC3654540, DOI: 10.1053/j.gastro.2011.07.051.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAcute Lung InjuryAdultAgedAged, 80 and overChemical and Drug Induced Liver InjuryDiagnosis, DifferentialFemaleHepatitis AntibodiesHepatitis EHepatitis E virusHumansImmunoglobulin GImmunoglobulin MMaleMiddle AgedPrevalenceProspective StudiesRetrospective StudiesUnited StatesConceptsDrug-induced liver injuryDrug-Induced Liver Injury NetworkAnti-HEV IgMAnti-HEV IgGLiver injuryHEV infectionAcute hepatitis E infectionHepatitis E virus infectionDrug-induced liver diseaseAcute hepatitis EAnti-HEV IgM.Acute viral hepatitisE virus infectionHepatitis E infectionViral hepatitis AAcute liver injuryHuman immunodeficiency virusE infectionHEV RNAClinical reassessmentHepatitis EViral hepatitisHepatitis AClinical featuresLiver diseaseAltered Folate Availability Modifies the Molecular Environment of the Human Colorectum: Implications for Colorectal Carcinogenesis
Protiva P, Mason JB, Liu Z, Hopkins ME, Nelson C, Marshall JR, Lambrecht RW, Pendyala S, Kopelovich L, Kim M, Kleinstein SH, Laird PW, Lipkin M, Holt PR. Altered Folate Availability Modifies the Molecular Environment of the Human Colorectum: Implications for Colorectal Carcinogenesis. Cancer Prevention Research 2011, 4: 530-543. PMID: 21321062, PMCID: PMC3742550, DOI: 10.1158/1940-6207.capr-10-0143.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiological AvailabilityCell Transformation, NeoplasticColonColorectal NeoplasmsDietary SupplementsDNA BreaksDNA MethylationFemaleFolic AcidFolic Acid DeficiencyGene ExpressionGene Expression ProfilingHumansMaleMiddle AgedOligonucleotide Array Sequence AnalysisPromoter Regions, GeneticRectumReverse Transcriptase Polymerase Chain ReactionTumor Suppressor Protein p53ConceptsFolate supplementationFolate deliveryFolate depletionImmune responseColorectal carcinogenesisDNA strand breaksHuman colonColorectal cancer riskFolic acidSupplemental folic acidLow-folate dietLow folate statusImmune response pathwaysImmune-related pathwaysFirst studyRectosigmoid biopsiesRisk volunteersPrimary endpointGene array analysisPromoter-specific DNA methylationRepletion protocolFolate dietFolate levelsSecond studyFolate status
2008
Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug‐induced liver injury
Rochon J, Protiva P, Seeff LB, Fontana RJ, Liangpunsakul S, Watkins PB, Davern T, McHutchison JG, Network D. Reliability of the Roussel Uclaf Causality Assessment Method for assessing causality in drug‐induced liver injury. Hepatology 2008, 48: 1175-1183. PMID: 18798340, PMCID: PMC3618289, DOI: 10.1002/hep.22442.Peer-Reviewed Original ResearchConceptsRoussel Uclaf Causality Assessment MethodDrug-induced liver injuryCausality Assessment MethodLiver injuryDrug-induced liver injury casesDrug-Induced Liver Injury NetworkLiver injury casesCases of hepatotoxicityInterrater reliabilityStrength of associationDeviation ageCase of drugsTest-retest reliabilityTest-retest differencesCausality assessmentInjury casesInjuryFive-category scaleSame reviewersSame assessorPhenytoinReviewersIsoniazidAmoxicillinResearch settings