2012
Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ Mice
Kadaveru K, Protiva P, Greenspan EJ, Kim YI, Rosenberg DW. Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ Mice. Cancer Prevention Research 2012, 5: 911-920. PMID: 22677908, PMCID: PMC3397832, DOI: 10.1158/1940-6207.capr-11-0544.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkers, TumorCaloric RestrictionDietFolic AcidFolic Acid DeficiencyGene Expression ProfilingGenes, APCHumansIntestinal NeoplasmsMiceMice, Inbred C57BLOligonucleotide Array Sequence AnalysisReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSignal TransductionConceptsWeeks of ageIntestinal tumorigenesisCancer protectionNormal-appearing colonic mucosaMethyl donor statusSmall intestinal tumorsHigh-risk populationDietary folate supplementationVitamin B12 depletionColon cancer riskIntestinal tumor formationBody weight gainMD miceTumor numberTumor sizeMDS groupIntestinal tumorsColonic mucosaFolate supplementationProtective effectB12 depletionInflammatory signalingCancer riskDeficient dietFolate deficiency
2007
Alcohol Regulates Gene Expression in Neurons via Activation of Heat Shock Factor 1
Pignataro L, Miller AN, Ma L, Midha S, Protiva P, Herrera DG, Harrison NL. Alcohol Regulates Gene Expression in Neurons via Activation of Heat Shock Factor 1. Journal Of Neuroscience 2007, 27: 12957-12966. PMID: 18032669, PMCID: PMC6673276, DOI: 10.1523/jneurosci.4142-07.2007.Peer-Reviewed Original ResearchConceptsHeat shock factor 1Alcohol-responsive genesShock factor 1Gene expressionHeat shockHSF1-dependent genesDownstream DNA sequenceHeat shock pathwayNeuron-specific genesARE-like sequencesFactor 1Long-term physiological changesDNA sequencesAlters transcriptionSequence elementsMicroarray analysisHSF1 levelsResponse elementMouse cortical neuronsGenesMouse cerebral cortexShock pathwayGABRA4Cultured neuronsHSP70