2008
Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response
Protiva P, Hopkins ME, Baggett S, Yang H, Lipkin M, Holt PR, Kennelly EJ, Bernard WI. Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response. International Journal Of Cancer 2008, 123: 687-694. PMID: 18470880, DOI: 10.1002/ijc.23515.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 4ApoptosisBenzophenonesCaspasesCell CycleCell Line, TumorCell SurvivalColonic NeoplasmsDNA-Binding ProteinsEndoplasmic ReticulumGarciniaGene Expression Regulation, NeoplasticHCT116 CellsHT29 CellsHumansInhibitory Concentration 50Linear ModelsMitochondrial MembranesNuclear ProteinsPrenylationProtein KinasesReactive Oxygen SpeciesRegulatory Factor X Transcription FactorsSignal TransductionTOR Serine-Threonine KinasesTranscription Factor CHOPTranscription FactorsUp-RegulationX-Box Binding Protein 1ConceptsEndoplasmic reticulum stress responseMitochondrial membrane potentialColon cancer cellsReticulum stress responseCaspase activationGene expressionStress responseSurvival pathwaysDDIT3/CHOPGuttiferone EEndoplasmic reticulum responseHuman colon cancer cellsParallel molecular pathwaysCell survival pathwaysCancer cellsCell linesMembrane potentialColon cancer cell linesHuman colon cancer cell linesREDD1 geneGene arrayMTOR survival pathwayCell cycleMolecular pathwaysCancer cell lines
2007
Alcohol Regulates Gene Expression in Neurons via Activation of Heat Shock Factor 1
Pignataro L, Miller AN, Ma L, Midha S, Protiva P, Herrera DG, Harrison NL. Alcohol Regulates Gene Expression in Neurons via Activation of Heat Shock Factor 1. Journal Of Neuroscience 2007, 27: 12957-12966. PMID: 18032669, PMCID: PMC6673276, DOI: 10.1523/jneurosci.4142-07.2007.Peer-Reviewed Original ResearchConceptsHeat shock factor 1Alcohol-responsive genesShock factor 1Gene expressionHeat shockHSF1-dependent genesDownstream DNA sequenceHeat shock pathwayNeuron-specific genesARE-like sequencesFactor 1Long-term physiological changesDNA sequencesAlters transcriptionSequence elementsMicroarray analysisHSF1 levelsResponse elementMouse cortical neuronsGenesMouse cerebral cortexShock pathwayGABRA4Cultured neuronsHSP70