Petr Protiva, MD, MPH
Associate Professor of Medicine (Digestive Diseases)Cards
Appointments
Additional Titles
Adjunct Faculty at Breslow Lab, Rockefeller University, New York, NY
Contact Info
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States
Appointments
Additional Titles
Adjunct Faculty at Breslow Lab, Rockefeller University, New York, NY
Contact Info
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States
Appointments
Additional Titles
Adjunct Faculty at Breslow Lab, Rockefeller University, New York, NY
Contact Info
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States
About
Titles
Associate Professor of Medicine (Digestive Diseases)
Adjunct Faculty at Breslow Lab, Rockefeller University, New York, NY
Biography
Dr Protiva is a clinician scientist with focus on colon cancer biology, screening and prevention. Main goal of his research is to identify the biological pathways and interventions that modulate the risk of cancer with special focus on colon cancer and nutrition. His laboratory focuses on cancer prevention and investigates the molecular events underlying preventive interventions using translational approach in a highly controlled settings. His group elucidated molecular events underlying the effects of estrogen, folic acid, vitamin D, calcium and Western style diet in human colorectal tissue.
Dr Protiva’s additional cancer research project involve clinical research. He serves as a local site investigator for the largest interventional VA study – CSP#577 – investigating the effect of colonoscopy vs FIT on mortality from colon cancer (50,000 subjects randomized).
In addition, Dr Protiva conducts epidemiology research using healthcare databases, exploring large patient datasets and generating hypotheses for future cancer research.
Other focus of his laboratory is the analysis and systems approach to basic and translational research questions using genome wide gene expression analysis. He collaborates with other researchers that show overlap with his interest in colon cancer biology or interpretation of large-scale gene expression data.
He serves as an Associate Editor for the BMJ Open Gastroenterology where he manages manuscripts related to luminal GI research.
Appointments
Digestive Diseases
Associate Professor on TermPrimary
Other Departments & Organizations
Education & Training
- MPH
- Yale University, Applied Biostatistics and Epidemiology (2017)
- Research Associate
- Rockefeller University, New York, NY (2006)
- MD
- Charles University (1993)
- BA
- Masaryk University (1987)
Board Certifications
Gastroenterology
- Certification Organization
- AB of Internal Medicine
- Latest Certification Date
- 2023
- Original Certification Date
- 2003
Research
Overview
Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM)
This is a VA Multisite Study. The purpose of this study is to compare two types of colon cancer screening tests and determine which is more effective in preventing death from colon and rectal cancer. These tests have not been compared in a large study and it is not clear which test is more effective Role: Site Principal Investigator/Local Site Investigator
Effect of Dietary Folate Supplementation and Depletion on Human Colonic Mucosa
Adequate folate status is important for optimal one carbon metabolic processes including the synthesis and methylation of DNA and genomic stability. This may impact the risk of cancer. The purpose of this study was to examine the effect of folate depletion-repletion and supplementation on gene expression and genomic stability in human colorectal mucosa. Multiple additional biomarkers were measured.
Inadequate calcium and vitamin D levels/intake are implicated in colorectal carcinogenesis. The purpose of this study was to examine the effect of Western style diet +/- calcium and/or vitamin D on gene expression in human colorectal mucosa.
Medical Subject Headings (MeSH)
ORCID
0000-0002-5566-8820
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Anil Nagar, MD
Deborah Proctor, MD
Jill Gaidos, MD
Jonathan Fetene, MD
Albert Do, MD, MPH
Avlin Imaeda, MD, PhD
Colorectal Neoplasms
Endpoint Determination
Publications
2024
Impact of COVID-19 Treatment on Real-World Outcomes in Inflammatory Bowel Disease
Sahyoun L, Fetene J, McMillan C, Protiva P, Al Bawardy B, Gaidos J, Proctor D. Impact of COVID-19 Treatment on Real-World Outcomes in Inflammatory Bowel Disease. Digestive Diseases And Sciences 2024, 69: 1654-1660. PMID: 38466459, DOI: 10.1007/s10620-024-08355-3.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSevere COVID-19 infectionInflammatory bowel diseaseCOVID-19 infectionIBD flareIBD therapyCOVID-19 treatmentSingle-center retrospective study of adult patientsMethodsA single-center retrospective studyAdvanced therapiesRetrospective study of adult patientsBowel diseaseStudy of adult patientsInflammatory bowel disease therapyDevelopment of severe COVID-19 infectionSevere COVID-19Acute COVID-19Corticosteroid useNo significant differenceNo therapyAdult patientsSupplemental oxygenPrimary outcomeSecondary outcomesTherapyCorticosteroids
2023
Endoscopic drainage of pancreatic fluid collections: Does hospital volume impact outcomes?
Ketwaroo G, Protiva P. Endoscopic drainage of pancreatic fluid collections: Does hospital volume impact outcomes? Gastrointestinal Endoscopy 2023, 98: 607-608. PMID: 37734815, DOI: 10.1016/j.gie.2023.06.057.Peer-Reviewed Original ResearchS290 Primary Squamous Cell Carcinoma of the Colon Is Extremely Rare and Shows Poor Survival
Protiva L, Ketwaroo G, Protiva P. S290 Primary Squamous Cell Carcinoma of the Colon Is Extremely Rare and Shows Poor Survival. The American Journal Of Gastroenterology 2023, 118: s214-s215. DOI: 10.14309/01.ajg.0000950800.62837.6b.Peer-Reviewed Original ResearchS1805 Small Bowel Adenocarcinomas Exhibit Worse Mortality Compared to Neuroendocrine Tumors With Modulation by Clinical, Demographic, and Socioeconomic Factors
Chung S, Khan F, Ketwaroo G, Protiva P. S1805 Small Bowel Adenocarcinomas Exhibit Worse Mortality Compared to Neuroendocrine Tumors With Modulation by Clinical, Demographic, and Socioeconomic Factors. The American Journal Of Gastroenterology 2023, 118: s1339-s1341. DOI: 10.14309/01.ajg.0000956860.65692.57.Peer-Reviewed Original ResearchS3865 A Protein Paradox: A Case of Spontaneous Portosystemic Shunt Encephalopathy and Protein-Losing Enteropathy
Maxwell M, Mezzacappa C, Hussain N, Protiva P, Cornman-Homonoff J, DiDomenico P, Ketwaroo G, Taddei T. S3865 A Protein Paradox: A Case of Spontaneous Portosystemic Shunt Encephalopathy and Protein-Losing Enteropathy. The American Journal Of Gastroenterology 2023, 118: s2470-s2471. DOI: 10.14309/01.ajg.0000965100.38497.c8.Peer-Reviewed Original ResearchConceptsS1000 Exploring the Influence of COVID-19 Treatment on Real-World Outcomes in IBD Patients: A Comprehensive Analysis
Sahyoun L, McMillan C, Fetene J, Protiva P, Al-Bawardy B, Gaidos J, Proctor D. S1000 Exploring the Influence of COVID-19 Treatment on Real-World Outcomes in IBD Patients: A Comprehensive Analysis. The American Journal Of Gastroenterology 2023, 118: s757-s757. DOI: 10.14309/01.ajg.0000953640.32433.d2.Peer-Reviewed Original ResearchS457 Associations of Intratumoral Alphapapillomavirus With Survival Outcomes and Tumorigenic Pathways in Esophageal Squamous Cell Carcinoma
Chen G, Zaman S, McMillan C, Patel A, Segarra D, Protiva P. S457 Associations of Intratumoral Alphapapillomavirus With Survival Outcomes and Tumorigenic Pathways in Esophageal Squamous Cell Carcinoma. The American Journal Of Gastroenterology 2023, 118: s332-s333. DOI: 10.14309/01.ajg.0000951468.46020.24.Peer-Reviewed Original ResearchBaseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial
Robertson D, Dominitz J, Beed A, Boardman K, Del Curto B, Guarino P, Imperiale T, LaCasse A, Larson M, Gupta S, Lieberman D, Planeta B, Shaukat A, Sultan S, Menees S, Saini S, Schoenfeld P, Goebel S, von Rosenvinge E, Baffy G, Halasz I, Pedrosa M, Kahng L, Cassim R, Greer K, Kinnard M, Bhatt D, Dunbar K, Harford W, Mengshol J, Olson J, Patel S, Antaki F, Fisher D, Sullivan B, Lenza C, Prajapati D, Wong H, Beyth R, Lieb J, Manlolo J, Ona F, Cole R, Khalaf N, Kahi C, Kohli D, Rai T, Sharma P, Anastasiou J, Hagedorn C, Fernando R, Jackson C, Jamal M, Lee R, Merchant F, May F, Pisegna J, Omer E, Parajuli D, Said A, Nguyen T, Tombazzi C, Feldman P, Jacob L, Koppelman R, Lehenbauer K, Desai D, Madhoun M, Tierney W, Ho M, Hockman H, Lopez C, Carter Paulson E, Tobi M, Pinillos H, Young M, Ho N, Mascarenhas R, Promrat K, Mutha P, Pandak W, Shah T, Schubert M, Pancotto F, Gawron A, Underwood A, Ho S, Magno-Pagatzaurtundua P, Toro D, Beymer C, Kaz A, Elwing J, Gill J, Goldsmith S, Yao M, Protiva P, Pohl H, Kyriakides T, Kleiner E, Sullivan K, O'Leary J, Chiu W, Huang H, Russo J, Johnson G, Antonelli P, Burns A, Peduzzi P, Ciarleglio M, O'Connor T, Wallace R, Williams A, Tommessilli L, Taylor S, Pitts S, Mancini L, O'Brien P, O'Neil S, Perry M, McBride V, Carr W, Joncas C, O'Donnell E, Sather M, Warren S, Conner T, Honstein E, Sutton T, Putnam T, Branham K, Argyres D, Peterson D, Kennedy A, Carrick T, Apodaca C, Eden G, Martinez T, Tripp C, Nicholson M, Schwartz A, Felix M, Ward A, Marquez L, Lovato K, Cochran N, Tapia S, VanRaden M, Badgett C, Taylor Z, Pontzer J, Dorman B, Chavez M, Georg S, Templton T, Calais L, Haakensen C, Curtis B, Prehoda M, Colling C, Older D, Apodaca G, Sova J, Klee M, Wolfram-Aduan A, Ulatowski M, Hamilton B, Bopp (Formerly England) K, Ford G, Lace N, McDonnell W, Piehl G, Patel-Ejarque N, Berry M, Strubeck E, Chesnut L, Burridge L, Bean J, Kowal L, Voorhees (Formerly Rose) A, Ridley A, Croteau H, Bessett K, Fletcher C, Barbaresso M, Drummond A, Belanger K, McRobert E, Myers A, Trumble E, Rose P, Biswas A, Enache E, Shankin M, Strunk D, Simpson A, Harrison M, Prasad M, Robinson P, Flores A, Jananeh S, Tanukonda S, Ahmadi-Izadi G, Madihi S, Raufman J, Grady D, Britton A, Goldstein C, Thomas M, Lee V, Belizaire M, Costa C, Davis S, Decker M, Marrama A, Gilroy-Fanaras D, Gass J, Reece S, Tobin D, Carroll R, Ferreira M, Irvin D, Morken V, Covelli M, Medina T, Schiebel F, Shreves A, Shriver D, Frederick Y, Postle (formerly Matheny) C, Shaw J, Pastor D, Armstrong A, Kumaran V, Pinto A, Marshall V, McLarty S, Carlton J, Murphy K, McLemore K, Mortensen E, LePage J, Willis C, Berman K, Dunn T, Espinoza J, Schleski E, Shrader S, Gropp K, Kanaan Z, Miller L, Anees M, Judd S, Berchou V, Balogh D, Jones E, Covert K, Davis Y, Marbury C, Rambus M, Olgren E, Gellad Z, Sullivan B, Day T, Teehan S, Peters L, Hernandez-Chavez R, Murphy E, Cherry J, Graham E, Johnson J, Wooten W, Trujillo J, Harris M, Alizadeh M, Lo M, Sultan S, Brown L, Koster L, LeLaurin J, Irwin A, Kay N, Mckillip S, Lowe M, Yeralan S, Leehey D, McBurney C, Jain A, Park T, Broadwater L, El-Serag H, Shaib Y, Taylor E, Nair P, Broussard E, Gibson E, Hawkins R, Natividad T, Courtade D, Palmer M, Martinez S, Panagiotis K, Morrow C, Ballard C, Barker B, Garner M, McCalley S, Schwartzkopf A, Wright A, Titi M, Higbee A, Pratiksha S, Jones A, Shipe T, McKee J, Vennalaganti R, Terrey K, Maruf L, Brown D, Crouse E, Marchant-Miros K, Ussery B, Ducker L, Estell J, Porchia S, Kim M, Kim C, Chan B, Hayton A, Christiansen H, Peterson M, Ding G, Simpson V, Read S, Mamani G, Salazar J, Kato J, Bowie M, Carnevale R, Halim M, Sahagian A, Ibarra A, Travis Z, Garcia J, Gill A, Starzyk J, Sumarli S, Johnson V, Peresuh S, Quimby T, Cordova R, Herold L, Hawley A, Goo T, Kidao J, Lee R, Freidel C, Gutierrez E, Noorisharghi N, Ivie G, Jawish T, Partin S, Yoo G, Fabilane C, Noori N, Lang E, Senen S, Partin S, Fathi M, Chauvin R, Feiger J, Reataza M, Morgan T, Asghar A, Jacobs J, Kashefi M, May F, Ohning G, Padua D, Smutko V, Oh D, Kosoyan H, Dreskin B, Luu K, Alas A, Bharath P, Dixit V, Sanford** D, Vu J, Kadi S, Nwajuaku T, Smith J, Kincaid J, Mir M, Lanceta J, Rice J, Agarwal P, Augustine A, Prickel H, Vue J, Guerrero K, Levenson S, Aguilera-Fish A, Chestnut L, Jobse B, Lombardo C, Silver T, Ahmed N, Bockhold K, Koppelman R, Carneiro F, Garcia-Morales R, Spector D, Gomez J, Lehenbauer K, Reinink A, Anway R, Evans-Lindquist M, Eggers T, Green M, Pretti A, Meyeraan T, Condon D, Cavanagh M, DeFalco C, Cutting J, Joseph K, Dean S, Mitchell S, Phillips V, Krueger C, Zink D, Goldberg K, Patel N, Martinez Gonzalez M, Davis-Underwood H, O'Sullivan A, Suppes T, Bratcher K, Stern D, Wu R, Damisa J, Warsi R, Nguyen T, Pinillos H, Flowers E, Kuramoto A, Thurmond C, Orozco L, Farrell G, Jaynes R, Saenz P, Perez C, Collins J, Lin E, Onstad L, Pitts A, Osborn K, Kenworthy-Heinige T, Casey A, Gold D, Olivo C, Joos S, Subramanian S, Forro V, Cannady A, Usih J, Raitt M, Flynn M, Shittu Y, Jawaid M, Anderson R, Poole D, Butler C, Snead L, Christine H, Swanson G, Heumann D, Pandak W, Spataro J, Bajaj J, Solomon C, Smith Gilles H, Zafass A, Tilak S, Fuchs M, Davis M, Blackman L, Lemler J, Munsey R, Deebo J, McCarthy J, Noel M, Hurley R, Zurowski W, Sharpe A, Wilson K, Peets R, Lorenso B, Burrison S, Johnson D, Angelovic A, Erickson N, Hanson H, Bailey T, Genung K, Dulin H, Neuharth R, Clegg D, Velarde K, Dever J, Murphy M, Beck D, Wasil M, Vazquez J, O'Neil E, Ganji G, Ducom J, Lee M, Hovespians R, Margolis J, Simmons B, Sweeney (formerly St. Martin) J, Henry R, Martin-Ortiz J, Santiago-Rivera L, Gonzalez - Aviles G, Pedrosa C, Bird-Caceres J, Padilla B, Baez-Corujo F, Martinez- Ortiz Y, Vazquez E, Grigg-Gutierrez N, Laboy-Olivieri C, Urbina-Velez R, Andrews S, Rosa-Cruz S, Tirado-Montijo R, Otero-Aponte K, Martinez-Martino M, Freire A, Soto-Ramos A, Santana-Perez M, Araujo J, Vanderwarker C, Alexander J, Nevins E, LaGuire J, Guerrero L, Piehl G, Jenkins M, Chen T, Jang J, Tanus A, McKelvy P, Sayuk G, Chandiramani P, Vargo (Formerly Shoults) L, Vargo K, Lawrence S, Blythe K, Goldsmith S, Campbell R, Craddock M, Amodeo D, Reinhard R, Durant B, Wells B, Zoble A, Papademetriou M, Roche N, Adler P, Krishna A, Glaze D, Wijegunawardana D, Yeroushalmi S, Laine L, Mautner R, Bugaj J, Anderson J, Croteau H, Kingman L, Burridge L. Baseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial. JAMA Network Open 2023, 6: e2321730. PMID: 37432690, PMCID: PMC10336619, DOI: 10.1001/jamanetworkopen.2023.21730.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFecal immunochemical testImmunochemical testEligible individualsAnnual fecal immunochemical testColorectal Cancer Screening TrialScreening testVeterans Affairs Medical CenterAverage CRC riskCancer Screening TrialCancer mortality outcomesCross-sectional studySpecific screening testCase report formsColorectal Cancer StudyStudy participant characteristicsCross-sectional analysisStool testingCRC riskMortality outcomesColorectal cancerClinical trialsCONFIRM studyMedical CenterScreening preferencesHispanic ethnicityTu1230 INTRATUMORAL CYTOMEGALOVIRUS RNA SEQUENCES ARE ASSOCIATED WITH POOR SURVIVAL OUTCOMES AND THE UPREGULATION OF INFLAMMATORY PATHWAYS IN COLON ADENOCARCINOMA
Zaman S, Chen G, Segarra D, Patel A, Protiva P. Tu1230 INTRATUMORAL CYTOMEGALOVIRUS RNA SEQUENCES ARE ASSOCIATED WITH POOR SURVIVAL OUTCOMES AND THE UPREGULATION OF INFLAMMATORY PATHWAYS IN COLON ADENOCARCINOMA. Gastroenterology 2023, 164: s-1000. DOI: 10.1016/s0016-5085(23)03324-3.Peer-Reviewed Original ResearchTu1138 INCREASED INTRATUMORAL ALPHAPAPILLOMAVIRUS ABUNDANCE IS ASSOCIATED WITH IMPROVED DISEASE-SPECIFIC SURVIVAL IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Chen G, Zaman S, Segarra D, Patel A, Protiva P. Tu1138 INCREASED INTRATUMORAL ALPHAPAPILLOMAVIRUS ABUNDANCE IS ASSOCIATED WITH IMPROVED DISEASE-SPECIFIC SURVIVAL IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA. Gastroenterology 2023, 164: s-992-s-993. DOI: 10.1016/s0016-5085(23)03295-x.Peer-Reviewed Original Research
Academic Achievements and Community Involvement
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Meeting Planning and ParticipationCo-OrganizerDetailsObesity and microbiome research Meetings organizer, proposed topics and moderate session2019 - 2021
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Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States