2015
NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence
Manda K, Tripathi P, Hsi A, Ning J, Ruzinova M, Liapis H, Bailey M, Zhang H, Maher C, Humphrey P, Andriole G, Ding L, You Z, Chen F. NFATc1 promotes prostate tumorigenesis and overcomes PTEN loss-induced senescence. Oncogene 2015, 35: 3282-3292. PMID: 26477312, PMCID: PMC5012433, DOI: 10.1038/onc.2015.389.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell LineCell Line, TumorCell ProliferationCell Transformation, NeoplasticCellular SenescenceCytokinesGene Expression Regulation, NeoplasticHumansImmunohistochemistryMaleMice, KnockoutMice, NudeMice, TransgenicNFATC Transcription FactorsProstateProstatic NeoplasmsPTEN PhosphohydrolaseReverse Transcriptase Polymerase Chain ReactionTransplantation, HomologousTumor Cells, CulturedTumor MicroenvironmentConceptsProstate tumorigenesisHuman PCaNFATc1 activationNon-tumorigenic prostate cellsActivated T cells c1Cultured PCa cellsT cells c1Cellular senescenceRole of NFATc1Number of cytokinesActivation of NFATc1Proinflammatory cytokinesPCa cellsProstate cancerProstatic adenocarcinomaLuminal epitheliumMouse prostateCells c1Normal prostateOncogenic roleOncogene c-mycProstate tissueProstate cellsSoluble factorsNuclear factor
2006
Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger
Wild P, Giedl J, Stoehr R, Junker K, Boehm S, van Oers J, Zwarthoff E, Blaszyk H, Fine S, Humphrey P, Dehner L, Amin M, Epstein J, Hartmann A. Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger. The Journal Of Pathology 2006, 211: 18-25. PMID: 17072825, DOI: 10.1002/path.2075.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlphapapillomavirusChildChild, PreschoolChromosome AberrationsChromosomes, Human, Pair 9DNA Mismatch RepairDNA Mutational AnalysisDNA, ViralFemaleGene Expression ProfilingGenes, p53HumansImmunohistochemistryIn Situ Hybridization, FluorescenceLoss of HeterozygosityMaleMicrosatellite InstabilityOligonucleotide Array Sequence AnalysisPapillomaPolymerase Chain ReactionReceptor, Fibroblast Growth Factor, Type 3Urologic NeoplasmsUrotheliumConceptsPatients 19 yearsUrothelial neoplasmsUrothelial papillomaMicrosatellite instabilityClinical outcomesHuman papillomavirusTP53 mutationsHigh-grade papillary urothelial carcinomaNIH consensus panelEvidence of diseaseFavorable clinical outcomeLow malignant potentialChromosome arm 9pPapillary urothelial carcinomaComparative genomic hybridizationPapillary urothelial neoplasmHPV positivityYounger patientsMultifocal tumorsUrothelial carcinomaUrothelial tumorsMalignant potentialPolymerase chain reactionConsensus panelKi-67
2001
Chromosome 22q dosage in composite extrarenal rhabdoid tumors: Clonal evolution or a phenotypic mimic?
Fuller C, Pfeifer J, Humphrey P, Bruch L, Dehner L, Perry A. Chromosome 22q dosage in composite extrarenal rhabdoid tumors: Clonal evolution or a phenotypic mimic? Human Pathology 2001, 32: 1102-1108. PMID: 11679945, DOI: 10.1053/hupa.2001.28252.Peer-Reviewed Original ResearchFrequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma
Abdulkadir S, Carbone J, Naughton C, Humphrey P, Catalona W, Milbrandt J. Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma. Human Pathology 2001, 32: 935-939. PMID: 11567222, DOI: 10.1053/hupa.2001.27102.Peer-Reviewed Original ResearchConceptsHuman prostate cancerHuman prostate carcinomaProstate cancerProstate carcinomaProstatic intraepithelial neoplasia lesionsIntraepithelial neoplasia lesionsProstate carcinoma specimensExpression of Nab2Prostate tumor suppressorNeoplasia lesionsTumor gradeCarcinoma specimensProstate tumorigenesisTumor progressionTranscription factor EGR1Protein expressionEarly lossEGR1 levelsCarcinomaTumorigenic processCancerTumor suppressorSame stimuliEGR1Transcriptional activity
2000
Minimal Adenocarcinoma in Prostate Needle Biopsy Tissue
Thorson P, Humphrey P. Minimal Adenocarcinoma in Prostate Needle Biopsy Tissue. American Journal Of Clinical Pathology 2000, 114: 896-909. PMID: 11338479, DOI: 10.1309/kvpx-c1em-142l-1m6w.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAtrophyBiopsy, NeedleDiagnosis, DifferentialHumansHyperplasiaImmunohistochemistryKeratinsMaleProstatic NeoplasmsConceptsNeedle biopsy tissueProstate needle biopsy tissueMinor diagnostic criteriaBiopsy tissueProstatic adenocarcinomaDiagnostic criteriaMinimal adenocarcinomaHigh-grade prostatic intraepithelial neoplasiaAtypical small acinar proliferationFocal glandular atypiaValuable adjunctive studySmall acinar proliferationProstatic intraepithelial neoplasiaAtypical adenomatous hyperplasiaConstellation of findingsIntermediate histologic gradeMajor diagnostic challengeWhole prostate glandTissue factor expression and angiogenesisin human prostate carcinoma
Abdulkadir S, Carvalhal G, Kaleem Z, Kisiel W, Humphrey P, Catalona W, Milbrandt J. Tissue factor expression and angiogenesisin human prostate carcinoma. Human Pathology 2000, 31: 443-447. PMID: 10821491, DOI: 10.1053/hp.2000.6547.Peer-Reviewed Original Research
1998
Extrapulmonary inflammatory myofibroblastic tumor: a clinical and pathological survey.
Coffin C, Humphrey P, Dehner L. Extrapulmonary inflammatory myofibroblastic tumor: a clinical and pathological survey. Seminars In Diagnostic Pathology 1998, 15: 85-101. PMID: 9606801.Peer-Reviewed Original ResearchMeSH KeywordsCytogeneticsDNAGranuloma, Plasma CellHumansImmunohistochemistryMicroscopy, ElectronPloidiesConceptsInflammatory myofibroblastic tumorExtrapulmonary sitesAberrant inflammatory responseSoft tissue mesenchymal tumorsLow malignant potentialEpstein-Barr virusSpindle cell sarcomaSpindle cell neoplasmConstitutional symptomsInflammatory hypothesisInflammatory pseudotumorSurgical resectionInflammatory natureLocal recurrenceMyofibroblastic tumorPrognostic categoriesVascular invasionCell sarcomaPathological featuresMalignant potentialInflammatory processPathological diagnosisInflammatory responseCell neoplasmsEmbryonal rhabdomyosarcoma
1997
Clear cell neoplasms of the endocrine system and thymus.
Wick M, Ritter J, Humphrey P, Nappi O. Clear cell neoplasms of the endocrine system and thymus. Seminars In Diagnostic Pathology 1997, 14: 183-202. PMID: 9279975.Peer-Reviewed Original ResearchConceptsEndocrine systemClear cell tumorsClear cell neoplasmsPancreatic endocrine neoplasmsThymic malignanciesThymic lesionsRare lesionsCell tumorsEndocrine tumorsAdrenocortical proliferationParathyroid tumorsCell neoplasmsDifferential diagnosisPituitary adenomasSurgical pathologistsEndocrine neoplasmsSimilar lesionsNeoplasmsLesionsTumorsUltrastructural featuresLymphoid differentiationThymusDiagnosisGerm cells
1994
Overexpression of p53 and HER-2/neu Proteins as Prognostic Markers in Early Stage Breast Cancer
Marks J, Humphrey P, Wu K, Berry D, Bandarenko N, Kerns B, Iglehart J. Overexpression of p53 and HER-2/neu Proteins as Prognostic Markers in Early Stage Breast Cancer. Annals Of Surgery 1994, 219: 332-341. PMID: 7909221, PMCID: PMC1243148, DOI: 10.1097/00000658-199404000-00002.Peer-Reviewed Original ResearchConceptsHER-2/neuEarly-stage breast cancerStage breast cancerHER-2/neu oncogeneBreast cancerPrognostic valueHER-2/neu proteinNeu oncogeneGenetic abnormalitiesDuke University Medical CenterFailure-free survivalProgesterone receptor contentCohort of patientsLimited prognostic valueIndependent prognostic valueShorter survival timeParaffin-embedded specimensUniversity Medical CenterHER-2/neu geneOverexpression of p53Common genetic abnormalityNodal statusRetrospective cohortLow estrogenTumor sizeOverexpression of p53 Is Not a Feature of Benign and Early-Stage Borderline Epithelial Ovarian Tumors
Berchuck A, Kohler M, Hopkins M, Humphrey P, Robboy S, Rodriguez G, Soper J, Clarke-Pearson D, Bast R. Overexpression of p53 Is Not a Feature of Benign and Early-Stage Borderline Epithelial Ovarian Tumors. Gynecologic Oncology 1994, 52: 232-236. PMID: 7508877, DOI: 10.1006/gyno.1994.1037.Peer-Reviewed Original ResearchConceptsEpithelial ovarian tumorsOverexpression of p53Borderline epithelial ovarian tumorsEpithelial ovarian cancerOvarian tumorsBorderline tumorsOvarian cancerEarly-stage borderline ovarian tumorsStage I/II casesBenign epithelial ovarian tumorsInvasive epithelial ovarian cancerBorderline ovarian tumorsBenign ovarian tumorsStage III casesAdvanced stage casesBenign tumorsMutant p53 proteinP53 tumor suppressor gene productIII casesStage casesTumorsII casesP53 proteinTumor suppressor gene productP53
1993
Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma
Ibrahim S, Lightner V, Ventimiglia J, Ibrahim G, Walther P, Bigner D, Humphrey P. Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma. Human Pathology 1993, 24: 982-989. PMID: 7504654, DOI: 10.1016/0046-8177(93)90112-t.Peer-Reviewed Original ResearchConceptsWestern blot analysisIntraepithelial neoplasiaCarcinoma cell linesProstatic hyperplasiaProstatic tissueBlot analysisAdult prostatic tissuesMetastatic prostatic carcinomaGrade of adenocarcinomaHuman prostatic carcinoma cell linesBone marrow samplesProstatic carcinoma cell linesHuman prostate tissueCell linesExpression of tenascinConnective tissue frameworkLymph nodesHistologic gradeProstatic carcinomaStromal alterationsTenascin immunoreactivityMarrow samplesStrong immunoreactivityStromal immunoreactivityProstate tissueAtypical adenomatous hyperplasia of the prostate: Morphologic criteria for its distinction from well-differentiated carcinoma
Bostwick D, Srigley J, Grignon D, Maksem J, Humphrey P, van der Kwast T, Bose D, Harrison J, Young R. Atypical adenomatous hyperplasia of the prostate: Morphologic criteria for its distinction from well-differentiated carcinoma. Human Pathology 1993, 24: 819-832. PMID: 8375853, DOI: 10.1016/0046-8177(93)90131-y.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaCarcinomaDiagnosis, DifferentialHumansHyperplasiaImmunohistochemistryMaleObserver VariationProstateProstatic NeoplasmsConceptsAtypical adenomatous hyperplasiaDifferential Immunoreactivity of Epidermal Growth Factor Receptor in Benign, Dysplastic and Malignant Prostatic Tissues
Ibrahim G, Kerns B, MacDonald J, Ibrahim S, Kinney R, Humphrey P, Robertson C. Differential Immunoreactivity of Epidermal Growth Factor Receptor in Benign, Dysplastic and Malignant Prostatic Tissues. Journal Of Urology 1993, 149: 170-173. PMID: 7678041, DOI: 10.1016/s0022-5347(17)36032-9.Peer-Reviewed Original ResearchMeSH KeywordsAgedDiagnosis, DifferentialErbB ReceptorsHumansImmunohistochemistryMaleMiddle AgedProstatic HyperplasiaProstatic NeoplasmsConceptsBenign prostatic hyperplasiaEGFR immunoreactivityBasal cell layerLuminal cellsBasal cellsBPH tissueFactor receptorProstatic specific antigenMalignant prostatic tissueAreas of dysplasiaCell layerRadical prostatectomy specimensCap tissueEpidermal growth factor receptorGrowth factor receptorEGFR contentProstatic hyperplasiaImmunohistochemical examinationProstatic carcinomaProstatic specimensProstatectomy specimensProstatic tissue
1992
Immunoreactive Prostatic Specific Antigen in Male Periurethral Glands
Frazier H, Humphrey P, Burchette J, Paulson D. Immunoreactive Prostatic Specific Antigen in Male Periurethral Glands. Journal Of Urology 1992, 147: 246-248. PMID: 1370330, DOI: 10.1016/s0022-5347(17)37206-3.Peer-Reviewed Original ResearchMeSH KeywordsAcid PhosphataseAntigens, NeoplasmExocrine GlandsHumansImmunohistochemistryMaleProstateProstate-Specific AntigenUrethraConceptsProstatic specific antigenProstatic acid phosphatasePeriurethral glandsSpecific antigenUrethral specimensMalignant prostatic tissueMale urethral specimensAutopsy seriesUrethral biopsyProstatic cancerAntigen uniqueAutopsy specimensProstatic tissueStrong immunostainingHeterogenous stainingAntigenAcid phosphataseRecent evidenceGlandTissueBiopsyEvidencePatientsCancerImmunostaining
1988
Pulmonary carcinomas with a sarcomatoid element: An immunocytochemical and ultrastructural analysis
Humphrey P, Scroggs M, Roggli V, Shelburne J. Pulmonary carcinomas with a sarcomatoid element: An immunocytochemical and ultrastructural analysis. Human Pathology 1988, 19: 155-165. PMID: 2449386, DOI: 10.1016/s0046-8177(88)80343-5.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoembryonic AntigenCarcinomaFemaleHumansImmunohistochemistryKeratinsLung NeoplasmsMaleMicroscopy, ElectronSarcomaConceptsSarcomatoid componentPulmonary carcinomaEpithelial differentiationSpindle cellsImmunocytochemical stainingSpindle cell populationSquamous cell carcinomaSpindle cell carcinomaSpindle cell componentUseful differentiating featureLight microscopyCell carcinomaPrimary carcinomaBiologic continuumBiphasic tumorSarcomatoid elementsUnusual neoplasmCarcinomaTumorsKeratin expressionUltrastructural examinationMesenchymal differentiationNeoplastic boneSharp demarcationUltrastructural analysis