2001
The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate Cancer
Vollmer R, Humphrey P. The Relative Importance of Anatomic and PSA Factors to Outcomes After Radical Prostatectomy for Prostate Cancer. American Journal Of Clinical Pathology 2001, 116: 864-870. PMID: 11764075, DOI: 10.1309/7mq7-mwar-4w8a-r75f.Peer-Reviewed Original ResearchConceptsElevated PSA levelsEarly deathPSA levelsRadical prostatectomyProstate cancerPathology observationsGleason grade 5Overall good prognosisTime of prostatectomyPostoperative levelsPSA failureStudy patientsBetter prognosisProgressive tumorsPrognostic categoriesPercentage carcinomaProstatectomySubsequent outcomesLower hazardDeathSurgeryHigher hazardCancerMenPSAFrequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma
Abdulkadir S, Carbone J, Naughton C, Humphrey P, Catalona W, Milbrandt J. Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma. Human Pathology 2001, 32: 935-939. PMID: 11567222, DOI: 10.1053/hupa.2001.27102.Peer-Reviewed Original ResearchConceptsHuman prostate cancerHuman prostate carcinomaProstate cancerProstate carcinomaProstatic intraepithelial neoplasia lesionsIntraepithelial neoplasia lesionsProstate carcinoma specimensExpression of Nab2Prostate tumor suppressorNeoplasia lesionsTumor gradeCarcinoma specimensProstate tumorigenesisTumor progressionTranscription factor EGR1Protein expressionEarly lossEGR1 levelsCarcinomaTumorigenic processCancerTumor suppressorSame stimuliEGR1Transcriptional activitySCATTER FACTOR-HEPATOCYTE GROWTH FACTOR ELEVATION IN THE SERUM OF PATIENTS WITH PROSTATE CANCER
NAUGHTON M, PICUS J, ZHU X, CATALONA W, VOLLMER R, HUMPHREY P. SCATTER FACTOR-HEPATOCYTE GROWTH FACTOR ELEVATION IN THE SERUM OF PATIENTS WITH PROSTATE CANCER. Journal Of Urology 2001, 165: 1325-1328. PMID: 11257710, DOI: 10.1016/s0022-5347(01)69893-8.Peer-Reviewed Original ResearchConceptsMetastatic prostate cancerProstate cancerMetastatic diseaseHepatocyte growth factorPatient ageSerum levelsNegative sextant prostate biopsiesProstate-specific antigen levelHuman prostate cancer cell linesAvailable enzyme-linked immunosorbentSextant prostate biopsySpecific antigen levelsNegative sextant biopsiesProstate cancer cell linesSera of patientsImportant serum markerLogistic regression analysisEnzyme-linked immunosorbentCancer cell linesLocalized cancerRadiographic evidenceSerum markersAntigen levelsSextant biopsyProstate biopsy
2000
Minimal Adenocarcinoma in Prostate Needle Biopsy Tissue
Thorson P, Humphrey P. Minimal Adenocarcinoma in Prostate Needle Biopsy Tissue. American Journal Of Clinical Pathology 2000, 114: 896-909. PMID: 11338479, DOI: 10.1309/kvpx-c1em-142l-1m6w.Peer-Reviewed Original ResearchConceptsNeedle biopsy tissueProstate needle biopsy tissueMinor diagnostic criteriaBiopsy tissueProstatic adenocarcinomaDiagnostic criteriaMinimal adenocarcinomaHigh-grade prostatic intraepithelial neoplasiaAtypical small acinar proliferationFocal glandular atypiaValuable adjunctive studySmall acinar proliferationProstatic intraepithelial neoplasiaAtypical adenomatous hyperplasiaConstellation of findingsIntermediate histologic gradeMajor diagnostic challengeWhole prostate glandTissue factor expression and angiogenesisin human prostate carcinoma
Abdulkadir S, Carvalhal G, Kaleem Z, Kisiel W, Humphrey P, Catalona W, Milbrandt J. Tissue factor expression and angiogenesisin human prostate carcinoma. Human Pathology 2000, 31: 443-447. PMID: 10821491, DOI: 10.1053/hp.2000.6547.Peer-Reviewed Original Research
1998
Pseudohyperplastic Prostatic Adenocarcinoma
Humphrey P, Kaleem Z, Swanson P, Vollmer R. Pseudohyperplastic Prostatic Adenocarcinoma. The American Journal Of Surgical Pathology 1998, 22: 1239-1246. PMID: 9777986, DOI: 10.1097/00000478-199810000-00009.Peer-Reviewed Original ResearchConceptsCases of adenocarcinomaProstatic adenocarcinomaHyperplastic featuresNeedle biopsyProstate carcinoma growthUsual epithelial hyperplasiaProstatic needle biopsyLow Gleason scoreLow-grade carcinomaRadical prostatectomy specimensRadical prostatectomy tissueGleason pattern 2Cystic dilatationPathologic stagePrognostic implicationsTumor sizeGleason scoreHistologic gradePapillary infoldingsRadical prostatectomyUsual hyperplasiaHistologic variantsPrognostic informationProstatic carcinomaCarcinomatous fociProstatic Adenocarcinoma With Atrophic Features: A Study of 202 Consecutive Completely Embedded Radical Prostatectomy Specimens
Kaleem Z, Swanson P, Vollmer R, Humphrey P. Prostatic Adenocarcinoma With Atrophic Features: A Study of 202 Consecutive Completely Embedded Radical Prostatectomy Specimens. American Journal Of Clinical Pathology 1998, 109: 695-703. PMID: 9620026, DOI: 10.1093/ajcp/109.6.695.Peer-Reviewed Original ResearchConceptsAtrophic featuresProstatic adenocarcinomaRadical prostatectomy specimensProstatic carcinomaAtrophic carcinomaProliferation indexProstatectomy specimensCarcinoma volumeUsual prostatic adenocarcinomaInfiltrative growth patternMean proliferation indexKi-67 immunolabelingBiotin nick end labelingRadical prostatectomy casesProstatic adenocarcinoma casesGleason grade 3Nick end labelingAtrophic patternUntreated patientsAtrophic changesPathologic stagePrognostic implicationsGlandular atrophyHistologic gradeAdenocarcinoma casesDiagnostic Effect of Complete Histologic Sampling of Prostate Needle Biopsy Specimens
Reyes A, Humphrey P. Diagnostic Effect of Complete Histologic Sampling of Prostate Needle Biopsy Specimens. American Journal Of Clinical Pathology 1998, 109: 416-422. PMID: 9535395, DOI: 10.1093/ajcp/109.4.416.Peer-Reviewed Original ResearchConceptsHigh-grade PINProstate needle biopsy specimensFocal glandular atypiaNeedle biopsy tissueNeedle biopsy specimensBenign prostatic tissueAdditional slidesHistologic abnormalitiesBiopsy specimensGlandular atypiaHistologic samplingNeedle biopsyProstatic tissueBiopsy tissueProstate needle core biopsiesNeedle core biopsyProstate needle biopsyComplete histopathologic examinationDetection of carcinomaDiagnostic effectComplete histologic examinationAdditional histologicProspective studyDefinitive diagnosisHistopathologic examination
1997
Unusual Histologic Types of High-Grade Prostatic Intraepithelial Neoplasia
Reyes A, Swanson P, Carbone J, Humphrey P. Unusual Histologic Types of High-Grade Prostatic Intraepithelial Neoplasia. The American Journal Of Surgical Pathology 1997, 21: 1215-1222. PMID: 9331295, DOI: 10.1097/00000478-199710000-00013.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaSignet ring cellsSmall cell carcinoma cellsProstatic intraepithelial neoplasiaProstate-specific antigenInvasive carcinomaIntraepithelial neoplasiaPrimary signet-ring cell carcinomaGrade prostatic intraepithelial neoplasiaSignet ring cell carcinomaCases of HGPINCarcinoma cellsNeuron-specific enolaseProstatic cell typesUnusual histologic typeSmall cell neuroendocrineGlandular epithelial cellsArchitectural growth patternIntraepithelial proliferationMucinous distensionCell typesMucinous featuresStrength of associationHistologic typeCell carcinomaThe Significance of Intraluminal Crystalloids in Benign Prostatic Glands on Needle Biopsy
Henneberry J, Kahane H, Humphrey P, Keetch D, Epstein J. The Significance of Intraluminal Crystalloids in Benign Prostatic Glands on Needle Biopsy. The American Journal Of Surgical Pathology 1997, 21: 725-728. PMID: 9199652, DOI: 10.1097/00000478-199706000-00014.Peer-Reviewed Original ResearchConceptsHigh-grade prostatic intraepithelial neoplasiaProstatic intraepithelial neoplasiaRepeat biopsyNeedle biopsyBenign glandsIntraluminal crystalloidsIntraepithelial neoplasiaBiopsy resultsSerum prostatic specific antigen (PSA) levelsSerum prostate-specific antigen valuesProstatic-specific antigen levelProstate-specific antigen valuesConsecutive needle biopsiesSpecific antigen levelsBenign prostatic glandsIncidence of cancerJohns Hopkins HospitalProstate biopsy resultsDianon SystemsConcurrent carcinomaSubsequent biopsyFirst biopsyAntigen levelsCystoprostatectomy specimensAntigen valuesMetastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal Samples
Mallow D, Humphrey P, Soper J, Johnston W. Metastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal Samples. Acta Cytologica 1997, 41: 549-555. PMID: 9100797, DOI: 10.1159/000332555.Peer-Reviewed Original ResearchConceptsMetastatic lobular carcinomaLobular carcinomaCervicovaginal samplesCervicovaginal smearsHuman milk fat globule membraneEpithelial membrane antigenEpidermal growth factor receptorExtragenital originExtrauterine cancerGrowth factor receptorMalignant tumorsTherapeutic implicationsMembrane antigenCarcinoembryonic antigenHistologic correlationFactor receptorMarker studiesCarcinomaMilk fat globule membraneBreastAntigenSmearsFat globule membraneGlobule membraneTumors
1993
Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma
Ibrahim S, Lightner V, Ventimiglia J, Ibrahim G, Walther P, Bigner D, Humphrey P. Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma. Human Pathology 1993, 24: 982-989. PMID: 7504654, DOI: 10.1016/0046-8177(93)90112-t.Peer-Reviewed Original ResearchConceptsWestern blot analysisIntraepithelial neoplasiaCarcinoma cell linesProstatic hyperplasiaProstatic tissueBlot analysisAdult prostatic tissuesMetastatic prostatic carcinomaGrade of adenocarcinomaHuman prostatic carcinoma cell linesBone marrow samplesProstatic carcinoma cell linesHuman prostate tissueCell linesExpression of tenascinConnective tissue frameworkLymph nodesHistologic gradeProstatic carcinomaStromal alterationsTenascin immunoreactivityMarrow samplesStrong immunoreactivityStromal immunoreactivityProstate tissueComplete Histologic Serial Sectioning of a Prostate Gland with Adenocarcinoma
Humphrey P. Complete Histologic Serial Sectioning of a Prostate Gland with Adenocarcinoma. The American Journal Of Surgical Pathology 1993, 17: 468-472. PMID: 8470761, DOI: 10.1097/00000478-199305000-00005.Peer-Reviewed Original ResearchStratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels
Humphrey P, Frazier H, Vollmer R, Paulson D. Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels. Cancer 1993, 71: 1821-1827. PMID: 7680602, DOI: 10.1002/1097-0142(19930301)71:5<1821::aid-cncr2820710517>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsPostoperative PSA levelPostoperative serum PSA levelsSerum PSA levelsRadical prostatectomy specimensIntraglandular tumor extentPSA levelsPathologic stageMargin positivityProstate-specific antigenHistologic gradeProstatectomy specimensResidual carcinomaPathologic featuresTumor extentSerum prostate-specific antigen levelPercentage carcinomaProstate-specific antigen levelExtension of carcinomaGleason histologic gradeOrgan-confined carcinomaLogistic regression analysisImportant morphologic parametersIntraglandular carcinomaAntigen levelsRadical prostatectomy
1991
Histologic Grade, DNA Ploidy, and Intraglandular Tumor Extent as Indicators of Tumor Progression of Clinical Stage B Prostatic Carcinoma
Humphrey P, Walther P, Currin S, Vollmer R. Histologic Grade, DNA Ploidy, and Intraglandular Tumor Extent as Indicators of Tumor Progression of Clinical Stage B Prostatic Carcinoma. The American Journal Of Surgical Pathology 1991, 15: 1165-1170. PMID: 1746683, DOI: 10.1097/00000478-199112000-00007.Peer-Reviewed Original ResearchConceptsHistologic gradeDNA ploidyTumor progressionTumor areaClinical stage B adenocarcinomaIntraglandular tumor extentStage B adenocarcinomaIndependent predictive factorsCox model analysisLikelihood of aneuploidyLogistic regression modelsB adenocarcinomaPredictive factorsTumor extensionProstatic carcinomaTumor extentProstatectomy specimensMultivariate analysisConcurrent useProgressionAdditional predictive abilityProstateImportant predictorRegression models
1990
Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens
Humphrey P, Vollmer R. Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens. Human Pathology 1990, 21: 799-804. PMID: 2387573, DOI: 10.1016/0046-8177(90)90048-a.Peer-Reviewed Original ResearchConceptsHistologic gradeTumor extentProstatectomy specimensTumor progressionPatient survivalProstatic carcinomaIntraglandular tumor extentExtent of tumorProportional hazards modelLogistic regression analysisSignificant prognosticatorPoor outcomeProstatic adenocarcinomaSurvival timeHazards modelProstatic tissueProstate glandEntire prostateProstate tissueConcurrent useTumorsCarcinomaProstateInterobserver agreement valuesProgression
1988
The ratio of prostate chips with cancer:A new measure of tumor extent and its relationship to grade and prognosis
Humphrey P, Vollmer R. The ratio of prostate chips with cancer:A new measure of tumor extent and its relationship to grade and prognosis. Human Pathology 1988, 19: 411-418. PMID: 3366451, DOI: 10.1016/s0046-8177(88)80490-8.Peer-Reviewed Original ResearchConceptsProstate cancerAdditive prognostic informationStage of tumorGleason histologic scoreChoice of patientsChance of deathCurative surgeryExtensive diseaseLocalized diseaseTransurethral prostatectomyGleason scoreProstate chipsPrognostic informationTumor extentHistologic scoresPatientsCancerLong-term failureDiseaseReliable predictorScoresInitial studyTotal numberPrognosticatorProstatectomy