2001
Visceral primitive peripheral neuroectodermal tumors: A clinicopathologic and molecular study
O'Sullivan M, Perlman E, Furman J, Humphrey P, Dehner L, Pfeifer J. Visceral primitive peripheral neuroectodermal tumors: A clinicopathologic and molecular study. Human Pathology 2001, 32: 1109-1115. PMID: 11679946, DOI: 10.1053/hupa.2001.28247.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal NeoplasmsAdolescentAdultBiomarkers, TumorDNA PrimersDNA, NeoplasmFemaleHumansImmunoenzyme TechniquesMaleMiddle AgedNeoplasm ProteinsNeuroectodermal Tumors, Primitive, PeripheralOncogene Proteins, FusionProto-Oncogene Protein c-fli-1Reverse Transcriptase Polymerase Chain ReactionRNA-Binding Protein EWSRNA, MessengerRNA, NeoplasmSarcoma, EwingSoft Tissue NeoplasmsTomography, X-Ray ComputedTranscription FactorsVisceraConceptsEWS/PNETSoft tissuePediatric small round blue cell tumorsSarcoma-primitive neuroectodermal tumorPolymerase chain reaction-based testingFusion transcriptsSmall round blue cell tumorsRound blue cell tumorsBlue cell tumorsClinicopathologic spectrumVisceral sitesPrognostic significanceVisceral originVisceral tumorsCell tumorsNeuroectodermal tumorAdditional casesTumorsPNETYoung adultsGenetic alterationsEts transcription factor familyBoneChromosomal translocationsEWS-FLI1Primitive Neuroectodermal Tumors of the Biliary and Gastrointestinal Tracts: Clinicopathologic and Molecular Diagnostic Study of Two Cases
Sarangarajan R, Hill D, Humphrey P, Hitchcock M, Dehner L, Pfeifer J. Primitive Neuroectodermal Tumors of the Biliary and Gastrointestinal Tracts: Clinicopathologic and Molecular Diagnostic Study of Two Cases. Pediatric And Developmental Pathology 2001, 4: 185-191. PMID: 11178636, DOI: 10.1007/s100240010141.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBile Duct NeoplasmsBiomarkers, TumorDNA PrimersDNA, NeoplasmFemaleHepatic Duct, CommonHumansImmunoenzyme TechniquesJejunal NeoplasmsMaleNeoplasm ProteinsNeoplasms, Second PrimaryNeuroectodermal Tumors, Primitive, PeripheralReverse Transcriptase Polymerase Chain ReactionRNA, NeoplasmSequence Analysis, DNAWilms TumorConceptsPrimitive neuroectodermal tumorNeuroectodermal tumorMalignant small round cell tumorMalignant soft tissue tumorsSmall round cell tumorSoft tissue tumorsRound cell tumorNon-classical sitesMore conventional sitesEWS-FLI1 gene fusionMolecular diagnostic studiesTranscription-polymerase chain reaction analysisCharacteristic immunoreactivityHepatic ductCell tumorsClinicopathologic profileTissue tumorsGastrointestinal tractChain reaction analysisUnusual siteSmall intestineTumorsMolecular findingsTumor cellsDiagnostic studiesInterobserver reproducibility of Gleason grading of prostatic carcinoma: Urologic pathologists
Allsbrook W, Mangold K, Johnson M, Lane R, Lane C, Amin M, Bostwick D, Humphrey P, Jones E, Reuter V, Sakr W, Sesterhenn I, Troncoso P, Wheeler T, Epstein J. Interobserver reproducibility of Gleason grading of prostatic carcinoma: Urologic pathologists. Human Pathology 2001, 32: 74-80. PMID: 11172298, DOI: 10.1053/hupa.2001.21134.Peer-Reviewed Original ResearchConceptsUrologic pathologistsProstatic carcinomaInterobserver reproducibilityGleason scoreGleason gradingGleason grade groupLow-grade tumorsCribriform proliferationNeedle biopsyGroup 2Gleason patternGrading systemCarcinomaGrade groupTumorsPathologistsScoresGradingKappa coefficientBiopsyHistologyCoefficient kappa
2000
WT1 Staining Reliably Differentiates Desmoplastic Small Round Cell Tumor From Ewing Sarcoma/Primitive Neuroectodermal Tumor
Hill D, Pfeifer J, Marley E, Dehner L, Humphrey P, Zhu X, Swanson P. WT1 Staining Reliably Differentiates Desmoplastic Small Round Cell Tumor From Ewing Sarcoma/Primitive Neuroectodermal Tumor. American Journal Of Clinical Pathology 2000, 114: 345-353. PMID: 10989634, DOI: 10.1093/ajcp/114.3.345.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal NeoplasmsAdolescentAdultBiomarkers, TumorBlotting, SouthernChildChild, PreschoolDiagnosis, DifferentialDNA PrimersDNA-Binding ProteinsDNA, NeoplasmFemaleFibromatosis, AggressiveHumansImmunoenzyme TechniquesMaleNeuroectodermal Tumors, PrimitiveOncogene Proteins, FusionParotid NeoplasmsReverse Transcriptase Polymerase Chain ReactionSarcoma, EwingSequence Analysis, DNATranscription FactorsWT1 ProteinsConceptsDesmoplastic small round cell tumorSmall round cell tumorRound cell tumorEWS/PNETSarcoma/primitive neuroectodermal tumorPrimitive neuroectodermal tumorCell tumorsWT1 antibodyImmunohistochemical featuresNeuroectodermal tumorDiagnosis of DSRCTMalignant small round cell tumorEwing sarcoma/primitive neuroectodermal tumorEWS/PNETsRT-PCRReverse transcriptase-polymerase chain reaction analysisTranscriptase-polymerase chain reaction analysisWT1 stainingEWS-WT1 fusionChain reaction analysisPredictive valueTumorsAvailable tissue
1997
Clear cell neoplasms of the endocrine system and thymus.
Wick M, Ritter J, Humphrey P, Nappi O. Clear cell neoplasms of the endocrine system and thymus. Seminars In Diagnostic Pathology 1997, 14: 183-202. PMID: 9279975.Peer-Reviewed Original ResearchConceptsEndocrine systemClear cell tumorsClear cell neoplasmsPancreatic endocrine neoplasmsThymic malignanciesThymic lesionsRare lesionsCell tumorsEndocrine tumorsAdrenocortical proliferationParathyroid tumorsCell neoplasmsDifferential diagnosisPituitary adenomasSurgical pathologistsEndocrine neoplasmsSimilar lesionsNeoplasmsLesionsTumorsUltrastructural featuresLymphoid differentiationThymusDiagnosisGerm cellsMetastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal Samples
Mallow D, Humphrey P, Soper J, Johnston W. Metastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal Samples. Acta Cytologica 1997, 41: 549-555. PMID: 9100797, DOI: 10.1159/000332555.Peer-Reviewed Original ResearchConceptsMetastatic lobular carcinomaLobular carcinomaCervicovaginal samplesCervicovaginal smearsHuman milk fat globule membraneEpithelial membrane antigenEpidermal growth factor receptorExtragenital originExtrauterine cancerGrowth factor receptorMalignant tumorsTherapeutic implicationsMembrane antigenCarcinoembryonic antigenHistologic correlationFactor receptorMarker studiesCarcinomaMilk fat globule membraneBreastAntigenSmearsFat globule membraneGlobule membraneTumors
1994
Overexpression of p53 Is Not a Feature of Benign and Early-Stage Borderline Epithelial Ovarian Tumors
Berchuck A, Kohler M, Hopkins M, Humphrey P, Robboy S, Rodriguez G, Soper J, Clarke-Pearson D, Bast R. Overexpression of p53 Is Not a Feature of Benign and Early-Stage Borderline Epithelial Ovarian Tumors. Gynecologic Oncology 1994, 52: 232-236. PMID: 7508877, DOI: 10.1006/gyno.1994.1037.Peer-Reviewed Original ResearchConceptsEpithelial ovarian tumorsOverexpression of p53Borderline epithelial ovarian tumorsEpithelial ovarian cancerOvarian tumorsBorderline tumorsOvarian cancerEarly-stage borderline ovarian tumorsStage I/II casesBenign epithelial ovarian tumorsInvasive epithelial ovarian cancerBorderline ovarian tumorsBenign ovarian tumorsStage III casesAdvanced stage casesBenign tumorsMutant p53 proteinP53 tumor suppressor gene productIII casesStage casesTumorsII casesP53 proteinTumor suppressor gene productP53
1992
Monoclonal antibodies to malignant human gliomas
Wikstrand C, Fredman P, Svennerholm L, Humphrey P, Bigner S, Bigner D. Monoclonal antibodies to malignant human gliomas. Journal Of Molecular Neuroscience 1992, 17: 137-146. PMID: 1384525, DOI: 10.1007/bf03159988.Peer-Reviewed Original ResearchConceptsPrimary CNS neoplasmsCNS neoplasmsHuman gliomasMonoclonal antibodiesMalignant brain tumorsHuman glioma xenograftsMalignant human gliomasAdult human brainNormal adult tissuesMAb localizationSpecific monoclonal antibodiesGlioma xenograftsBrain tumorsCytologic specimensFrozen sectionsEpitopic specificityGlioma biopsiesEGFR geneNeoplasmsGliomasVivo diagnosisMutant EGFREGFR proteinAntibodiesTumors
1990
Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens
Humphrey P, Vollmer R. Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens. Human Pathology 1990, 21: 799-804. PMID: 2387573, DOI: 10.1016/0046-8177(90)90048-a.Peer-Reviewed Original ResearchConceptsHistologic gradeTumor extentProstatectomy specimensTumor progressionPatient survivalProstatic carcinomaIntraglandular tumor extentExtent of tumorProportional hazards modelLogistic regression analysisSignificant prognosticatorPoor outcomeProstatic adenocarcinomaSurvival timeHazards modelProstatic tissueProstate glandEntire prostateProstate tissueConcurrent useTumorsCarcinomaProstateInterobserver agreement valuesProgression
1988
Pulmonary carcinomas with a sarcomatoid element: An immunocytochemical and ultrastructural analysis
Humphrey P, Scroggs M, Roggli V, Shelburne J. Pulmonary carcinomas with a sarcomatoid element: An immunocytochemical and ultrastructural analysis. Human Pathology 1988, 19: 155-165. PMID: 2449386, DOI: 10.1016/s0046-8177(88)80343-5.Peer-Reviewed Original ResearchConceptsSarcomatoid componentPulmonary carcinomaEpithelial differentiationSpindle cellsImmunocytochemical stainingSpindle cell populationSquamous cell carcinomaSpindle cell carcinomaSpindle cell componentUseful differentiating featureLight microscopyCell carcinomaPrimary carcinomaBiologic continuumBiphasic tumorSarcomatoid elementsUnusual neoplasmCarcinomaTumorsKeratin expressionUltrastructural examinationMesenchymal differentiationNeoplastic boneSharp demarcationUltrastructural analysisThe Localisation of Radiolabeled Murine Monoclonal Antibody 81C6 and its Fab Fragment in Human Glioma Xenografts in Athymic Mice
Colapinto E, Lee Y, Humphrey P, Zalutsky M, Friedman H, Bullard D, Bigner D. The Localisation of Radiolabeled Murine Monoclonal Antibody 81C6 and its Fab Fragment in Human Glioma Xenografts in Athymic Mice. British Journal Of Neurosurgery 1988, 2: 179-191. PMID: 3267302, DOI: 10.3109/02688698808992668.Peer-Reviewed Original ResearchConceptsMab 81C6Monoclonal antibody 81C6Dose/Athymic miceFab fragmentsHuman glioma xenograftsMG glioma cellsGlioma xenograftsHigh immunoreactivityIntracranial xenograftsGlioma cellsExtracellular matrix antigensNormal tissuesTissue ratioMarked lossRadiation dosesXenograftsImmunoreactivityTumorsMatrix antigensAntigenMiceTheoretical benefitsFab levelsGliomas