2008
Prognostic value of various morphometric measurements of tumour extent in prostate needle core tissue
Brimo F, Vollmer R, Corcos J, Kotar K, Bégin L, Humphrey P, Bismar T. Prognostic value of various morphometric measurements of tumour extent in prostate needle core tissue. Histopathology 2008, 53: 177-183. PMID: 18752501, DOI: 10.1111/j.1365-2559.2008.03087.x.Peer-Reviewed Original ResearchConceptsPathological stageTumor lengthPrognostic valueTumor extentFinal pathological stageHigher stage diseaseNeedle biopsy specimenCancer patient outcomesPrognostic significanceBiochemical recurrenceBiopsy specimenRadical prostatectomyPatient outcomesBiopsy reportingFailure statusCancer lengthPositive coresPathological outcomesLarger studyMorphometric measurementsDiscontinuous fociCancerCore tissuePatientsOutcomes
1996
Prospective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based Screening
Humphrey P, Keetch D, Smith D, Shepherd D, Catalona W. Prospective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based Screening. Journal Of Urology 1996, 155: 816-820.. DOI: 10.1097/00005392-199603000-00004.Peer-Reviewed Original ResearchProstate-specific antigenSerum prostate-specific antigenPathological featuresProstatic carcinomaSpecific antigenOrgan-confined prostate carcinomaCancerous surgical marginsGleason histological gradeIntraglandular tumor extentMost prostatic cancersMost prostatic carcinomasSurgical margin statusRadical prostatectomy specimensExtracapsular carcinomaAdvanced diseaseMargin statusSurgical marginsGleason scoreHistological gradePathological stageSurgical specimenProspective dataProstatic cancerTumor extentProspective characterizationProspective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based Screening
Humphrey P, Keetch D, Smith D, Shepherd D, Catalona W. Prospective characterization of pathological features of Prostatic Carcinomas Detected Via Serum Prostate Specific Antigen Based Screening. Journal Of Urology 1996, 155: 816-820. PMID: 8583583, DOI: 10.1016/s0022-5347(01)66316-x.Peer-Reviewed Original ResearchConceptsProstate-specific antigenSerum prostate-specific antigenPathological featuresProstatic carcinomaSpecific antigenOrgan-confined prostate carcinomaCancerous surgical marginsGleason histological gradeIntraglandular tumor extentMost prostatic cancersMost prostatic carcinomasSurgical margin statusRadical prostatectomy specimensExtracapsular carcinomaAdvanced diseaseMargin statusSurgical marginsGleason scoreHistological gradePathological stageSurgical specimenProspective dataProstatic cancerTumor extentProspective characterization
1993
Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels
Humphrey P, Frazier H, Vollmer R, Paulson D. Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels. Cancer 1993, 71: 1821-1827. PMID: 7680602, DOI: 10.1002/1097-0142(19930301)71:5<1821::aid-cncr2820710517>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsPostoperative PSA levelPostoperative serum PSA levelsSerum PSA levelsRadical prostatectomy specimensIntraglandular tumor extentPSA levelsPathologic stageMargin positivityProstate-specific antigenHistologic gradeProstatectomy specimensResidual carcinomaPathologic featuresTumor extentSerum prostate-specific antigen levelPercentage carcinomaProstate-specific antigen levelExtension of carcinomaGleason histologic gradeOrgan-confined carcinomaLogistic regression analysisImportant morphologic parametersIntraglandular carcinomaAntigen levelsRadical prostatectomy
1991
Histologic Grade, DNA Ploidy, and Intraglandular Tumor Extent as Indicators of Tumor Progression of Clinical Stage B Prostatic Carcinoma
Humphrey P, Walther P, Currin S, Vollmer R. Histologic Grade, DNA Ploidy, and Intraglandular Tumor Extent as Indicators of Tumor Progression of Clinical Stage B Prostatic Carcinoma. The American Journal Of Surgical Pathology 1991, 15: 1165-1170. PMID: 1746683, DOI: 10.1097/00000478-199112000-00007.Peer-Reviewed Original ResearchConceptsHistologic gradeDNA ploidyTumor progressionTumor areaClinical stage B adenocarcinomaIntraglandular tumor extentStage B adenocarcinomaIndependent predictive factorsCox model analysisLikelihood of aneuploidyLogistic regression modelsB adenocarcinomaPredictive factorsTumor extensionProstatic carcinomaTumor extentProstatectomy specimensMultivariate analysisConcurrent useProgressionAdditional predictive abilityProstateImportant predictorRegression models
1990
Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens
Humphrey P, Vollmer R. Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens. Human Pathology 1990, 21: 799-804. PMID: 2387573, DOI: 10.1016/0046-8177(90)90048-a.Peer-Reviewed Original ResearchConceptsHistologic gradeTumor extentProstatectomy specimensTumor progressionPatient survivalProstatic carcinomaIntraglandular tumor extentExtent of tumorProportional hazards modelLogistic regression analysisSignificant prognosticatorPoor outcomeProstatic adenocarcinomaSurvival timeHazards modelProstatic tissueProstate glandEntire prostateProstate tissueConcurrent useTumorsCarcinomaProstateInterobserver agreement valuesProgression
1988
The ratio of prostate chips with cancer:A new measure of tumor extent and its relationship to grade and prognosis
Humphrey P, Vollmer R. The ratio of prostate chips with cancer:A new measure of tumor extent and its relationship to grade and prognosis. Human Pathology 1988, 19: 411-418. PMID: 3366451, DOI: 10.1016/s0046-8177(88)80490-8.Peer-Reviewed Original ResearchConceptsProstate cancerAdditive prognostic informationStage of tumorGleason histologic scoreChoice of patientsChance of deathCurative surgeryExtensive diseaseLocalized diseaseTransurethral prostatectomyGleason scoreProstate chipsPrognostic informationTumor extentHistologic scoresPatientsCancerLong-term failureDiseaseReliable predictorScoresInitial studyTotal numberPrognosticatorProstatectomy