2000
Overexpression and regulation of expression of scatter factor/hepatocyte growth factor in prostatic carcinoma
Zhu X, Humphrey P. Overexpression and regulation of expression of scatter factor/hepatocyte growth factor in prostatic carcinoma. Urology 2000, 56: 1071-1074. PMID: 11113771, DOI: 10.1016/s0090-4295(00)00795-0.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factorVascular endothelial growth factorHGF expressionSF/HGF expressionEndothelial growth factorGrowth factorProstatic carcinomaIL-1betaStromal myofibroblastsProstatic tissueSF/HGFCarcinoma tissuesGrowth factors basic fibroblast growth factorCell linesProstatic epithelial cell linesHuman prostatic carcinoma tissueHuman prostatic tissue samplesProstatic tissue samplesProstatic carcinoma tissueBenign prostatic tissueHuman prostatic carcinomaHuman prostatic tissueMalignant human prostatic tissuesMultifunctional polypeptide growth factorsEnzyme-linked immunosorbent
1998
Diagnostic Effect of Complete Histologic Sampling of Prostate Needle Biopsy Specimens
Reyes A, Humphrey P. Diagnostic Effect of Complete Histologic Sampling of Prostate Needle Biopsy Specimens. American Journal Of Clinical Pathology 1998, 109: 416-422. PMID: 9535395, DOI: 10.1093/ajcp/109.4.416.Peer-Reviewed Original ResearchConceptsHigh-grade PINProstate needle biopsy specimensFocal glandular atypiaNeedle biopsy tissueNeedle biopsy specimensBenign prostatic tissueAdditional slidesHistologic abnormalitiesBiopsy specimensGlandular atypiaHistologic samplingNeedle biopsyProstatic tissueBiopsy tissueProstate needle core biopsiesNeedle core biopsyProstate needle biopsyComplete histopathologic examinationDetection of carcinomaDiagnostic effectComplete histologic examinationAdditional histologicProspective studyDefinitive diagnosisHistopathologic examination
1994
Development of a Mouse Model for Nonbacterial Prostatitis
Keetch D, Humphrey P, Ratliff T. Development of a Mouse Model for Nonbacterial Prostatitis. Journal Of Urology 1994, 152: 247-250. PMID: 8201676, DOI: 10.1016/s0022-5347(17)32871-9.Peer-Reviewed Original ResearchConceptsNonbacterial prostatitisProstatic inflammationC57BL/6-lpr miceLpr miceBALB/c miceAdoptive transfer studiesCommon clinical entityDegree of inflammationBALB/cPeriglandular regionsAutoimmune processAJ miceLymphocytic infiltrationC57BL/6 miceClinical entityProstate antigenC miceImmune parametersSyngeneic miceProstatitisMouse modelProstatic tissueDisease processAnimal modelsInflammation
1993
Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma
Ibrahim S, Lightner V, Ventimiglia J, Ibrahim G, Walther P, Bigner D, Humphrey P. Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma. Human Pathology 1993, 24: 982-989. PMID: 7504654, DOI: 10.1016/0046-8177(93)90112-t.Peer-Reviewed Original ResearchConceptsWestern blot analysisIntraepithelial neoplasiaCarcinoma cell linesProstatic hyperplasiaProstatic tissueBlot analysisAdult prostatic tissuesMetastatic prostatic carcinomaGrade of adenocarcinomaHuman prostatic carcinoma cell linesBone marrow samplesProstatic carcinoma cell linesHuman prostate tissueCell linesExpression of tenascinConnective tissue frameworkLymph nodesHistologic gradeProstatic carcinomaStromal alterationsTenascin immunoreactivityMarrow samplesStrong immunoreactivityStromal immunoreactivityProstate tissueDifferential Immunoreactivity of Epidermal Growth Factor Receptor in Benign, Dysplastic and Malignant Prostatic Tissues
Ibrahim G, Kerns B, MacDonald J, Ibrahim S, Kinney R, Humphrey P, Robertson C. Differential Immunoreactivity of Epidermal Growth Factor Receptor in Benign, Dysplastic and Malignant Prostatic Tissues. Journal Of Urology 1993, 149: 170-173. PMID: 7678041, DOI: 10.1016/s0022-5347(17)36032-9.Peer-Reviewed Original ResearchConceptsBenign prostatic hyperplasiaEGFR immunoreactivityBasal cell layerLuminal cellsBasal cellsBPH tissueFactor receptorProstatic specific antigenMalignant prostatic tissueAreas of dysplasiaCell layerRadical prostatectomy specimensCap tissueEpidermal growth factor receptorGrowth factor receptorEGFR contentProstatic hyperplasiaImmunohistochemical examinationProstatic carcinomaProstatic specimensProstatectomy specimensProstatic tissue
1992
Immunoreactive Prostatic Specific Antigen in Male Periurethral Glands
Frazier H, Humphrey P, Burchette J, Paulson D. Immunoreactive Prostatic Specific Antigen in Male Periurethral Glands. Journal Of Urology 1992, 147: 246-248. PMID: 1370330, DOI: 10.1016/s0022-5347(17)37206-3.Peer-Reviewed Original ResearchConceptsProstatic specific antigenProstatic acid phosphatasePeriurethral glandsSpecific antigenUrethral specimensMalignant prostatic tissueMale urethral specimensAutopsy seriesUrethral biopsyProstatic cancerAntigen uniqueAutopsy specimensProstatic tissueStrong immunostainingHeterogenous stainingAntigenAcid phosphataseRecent evidenceGlandTissueBiopsyEvidencePatientsCancerImmunostaining
1990
Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens
Humphrey P, Vollmer R. Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens. Human Pathology 1990, 21: 799-804. PMID: 2387573, DOI: 10.1016/0046-8177(90)90048-a.Peer-Reviewed Original ResearchConceptsHistologic gradeTumor extentProstatectomy specimensTumor progressionPatient survivalProstatic carcinomaIntraglandular tumor extentExtent of tumorProportional hazards modelLogistic regression analysisSignificant prognosticatorPoor outcomeProstatic adenocarcinomaSurvival timeHazards modelProstatic tissueProstate glandEntire prostateProstate tissueConcurrent useTumorsCarcinomaProstateInterobserver agreement valuesProgression