1997
Effect of Canarypox Virus (ALVAC)-Mediated Cytokine Expression on Murine Prostate Tumor Growth
Kawakita M, Rao G, Ritchey J, Ornstein D, Hudson M, Harmon T, Ratliff T, Humphrey P, Tartaglia J, Paoletti E. Effect of Canarypox Virus (ALVAC)-Mediated Cytokine Expression on Murine Prostate Tumor Growth. Journal Of The National Cancer Institute 1997, 89: 428-436. PMID: 9091644, DOI: 10.1093/jnci/89.6.428.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvipoxvirusB7-1 AntigenCytokinesDisease Models, AnimalFlow CytometryGene Expression Regulation, NeoplasticGene Expression Regulation, ViralGene Transfer TechniquesGenetic VectorsImmunotherapyInterferon-gammaInterleukin-2MaleMiceMice, Inbred C57BLMice, SCIDProstatic NeoplasmsTime FactorsTumor Necrosis Factor-alphaConceptsRM-1 cellsTumor cell expressionMouse prostate cancer cellsIL-2TNF-alphaC57BL/6 miceProstate cancer cellsTumor growthCell expressionTumor sizeB7-1Gene product expressionCo-stimulatory molecules B7-1Canarypox virusCytotoxic T lymphocyte activityKaplan-Meier survival methodMeasurable tumor sizeNonspecific antitumor activitySubsequent tumor challengeT lymphocyte activityCancer cellsCytotoxic T cellsInfected cellsProstate tumor growthMouse prostate tumor model
1994
Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells.
Day M, Zhao X, Wu S, Swanson P, Humphrey P. Phorbol ester-induced apoptosis is accompanied by NGFI-A and c-fos activation in androgen-sensitive prostate cancer cells. Molecular Cancer Research 1994, 5: 735-41. PMID: 7947388.Peer-Reviewed Original ResearchMeSH KeywordsAlkaloidsAndrogensApoptosisCarcinomaDNA DamageDNA-Binding ProteinsDNA, NeoplasmEarly Growth Response Protein 1Enzyme InductionGene Expression Regulation, NeoplasticHumansImmediate-Early ProteinsMaleNeoplasms, Hormone-DependentProstatic NeoplasmsProtein KinasesProto-Oncogene Proteins c-fosStaurosporineTetradecanoylphorbol AcetateTranscription FactorsTranscriptional ActivationTumor Cells, CulturedConceptsTranscription factor NGFIPhorbol ester-induced apoptosisC-fos gene activationEarly transcriptional regulationKinase signal transductionC-fosProtein kinase activatorsProstate cellsTranscriptional regulationGene activationSignal transductionProtein kinaseInduction of deathKinase activatorLNCaP cellsProstate cancer cellsProstate linesApoptotic bodiesCell deathDNA ladderTransient activationTransient inductionIntracellular pathwaysTPA-induced expressionNGFI