1998
Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2
Vollmer R, Humphrey P, Swanson P, Wick M, Hudson M. Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2. Journal Of Urology 1998, 160: 1935-1936. DOI: 10.1016/s0022-5347(01)62455-8.Peer-Reviewed Original ResearchTransitional cell carcinomaC-erb BExpression of p53Epidermal growth factor receptorGrowth factor receptorCell carcinomaHistologic gradeMIB-1Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2
Vollmer R, Humphrey P, Swanson P, Wick M, Hudson M. Invasion of the Bladder by Transitional Cell Carcinoma. Its Relation to Histologic Grade and Expression of p53, MIB-1, c-erb B-2, Epidermal Growth Factor Receptor, and bcl-2. Journal Of Urology 1998, 160: 1935-1936.. DOI: 10.1097/00005392-199811000-00095.Peer-Reviewed Original ResearchTransitional cell carcinomaC-erb BExpression of p53Epidermal growth factor receptorGrowth factor receptorCell carcinomaHistologic gradeMIB-1Invasion of the bladder by transitional cell carcinoma
Vollmer R, Humphrey P, Swanson P, Wick M, Hudson M. Invasion of the bladder by transitional cell carcinoma. Cancer 1998, 82: 715-723. PMID: 9477105, DOI: 10.1002/(sici)1097-0142(19980215)82:4<715::aid-cncr15>3.0.co;2-0.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorCarcinoma, Transitional CellEpidermal Growth FactorHumansImmunoenzyme TechniquesKi-67 AntigenLogistic ModelsNeoplasm InvasivenessNeoplasm ProteinsNeoplasm StagingPrognosisProspective StudiesProto-Oncogene Proteins c-bcl-2Receptor, ErbB-2Tumor Suppressor Protein p53Urinary Bladder NeoplasmsConceptsC-erb BTransitional cell carcinomaEpidermal growth factor receptorGrade 3 tumorsHistologic gradeMIB-1Cell carcinomaBcl-2Prognostic informationMultivariate logistic regression modelGrade 2 tumorsLogistic regression modelsWorld Health OrganizationGrowth factor receptorCombination of markersPrognostic factorsClinical outcomesProspective studyImmunohistochemical stainingPathologic levelsProtective effectLevel of invasionGrade 2Multivariate analysisCarcinoma
1997
Metastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal Samples
Mallow D, Humphrey P, Soper J, Johnston W. Metastatic Lobular Carcinoma of the Breast Diagnosed in Cervicovaginal Samples. Acta Cytologica 1997, 41: 549-555. PMID: 9100797, DOI: 10.1159/000332555.Peer-Reviewed Original ResearchConceptsMetastatic lobular carcinomaLobular carcinomaCervicovaginal samplesCervicovaginal smearsHuman milk fat globule membraneEpithelial membrane antigenEpidermal growth factor receptorExtragenital originExtrauterine cancerGrowth factor receptorMalignant tumorsTherapeutic implicationsMembrane antigenCarcinoembryonic antigenHistologic correlationFactor receptorMarker studiesCarcinomaMilk fat globule membraneBreastAntigenSmearsFat globule membraneGlobule membraneTumors
1993
Investigation of a synthetic peptide as immunogen for a variant epidermal growth factor receptor associated with gliomas
Wikstrand C, Stanley S, Humphrey P, Pegram C, Archer G, Kurpad S, Shibuya M, Bigner D. Investigation of a synthetic peptide as immunogen for a variant epidermal growth factor receptor associated with gliomas. Journal Of Neuroimmunology 1993, 46: 165-173. PMID: 8360327, DOI: 10.1016/0165-5728(93)90246-u.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorGrowth factor receptorVariant receptorHuman epidermal growth factor receptorFactor receptorVariant epidermal growth factor receptorResponse of miceHuman tumor samplesAdditional immunizationsPeptide immunizationAntibody activityAntibody productionSynthetic peptidesTumor samplesImmunizationReceptorsRabbitsSingle goatGliomasTitersReceptor proteinVariant formImmunogenPeptidesDifferential Immunoreactivity of Epidermal Growth Factor Receptor in Benign, Dysplastic and Malignant Prostatic Tissues
Ibrahim G, Kerns B, MacDonald J, Ibrahim S, Kinney R, Humphrey P, Robertson C. Differential Immunoreactivity of Epidermal Growth Factor Receptor in Benign, Dysplastic and Malignant Prostatic Tissues. Journal Of Urology 1993, 149: 170-173. PMID: 7678041, DOI: 10.1016/s0022-5347(17)36032-9.Peer-Reviewed Original ResearchConceptsBenign prostatic hyperplasiaEGFR immunoreactivityBasal cell layerLuminal cellsBasal cellsBPH tissueFactor receptorProstatic specific antigenMalignant prostatic tissueAreas of dysplasiaCell layerRadical prostatectomy specimensCap tissueEpidermal growth factor receptorGrowth factor receptorEGFR contentProstatic hyperplasiaImmunohistochemical examinationProstatic carcinomaProstatic specimensProstatectomy specimensProstatic tissue
1991
Deletion-mutant epidermal growth factor receptor in human gliomas: Effect of type II mutation on receptor function
Humphrey P, Gangarosa L, Wong A, Archer G, Lund-Johansen M, Bjerkvig R, Laerum O, Friedman H, Bigner D. Deletion-mutant epidermal growth factor receptor in human gliomas: Effect of type II mutation on receptor function. Biochemical And Biophysical Research Communications 1991, 178: 1413-1420. PMID: 1678600, DOI: 10.1016/0006-291x(91)91051-d.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceCell LineChromosome DeletionEpidermal Growth FactorErbB ReceptorsGene AmplificationGene RearrangementGliomaHumansKineticsMolecular Sequence DataPhosphorylationProtein-Tyrosine KinasesProto-Oncogene MasProto-Oncogene ProteinsProto-OncogenesReceptor, ErbB-2Transforming Growth Factor alphaConceptsEGFR kinase activityMutant EGFRDeletion-mutant epidermal growth factor receptorGrowth factor receptor geneMutant EGFR proteinEpidermal growth factor receptorGrowth factorFactor receptor geneEpidermal growth factor receptor (EGFR) geneGrowth factor receptorKinase activityExtracellular domainGlioma cell proliferationDomain IVFrame deletionType II mutationAmino acidsEGFR proteinFactor receptorReceptor geneThree-dimensional spheroid modelCell proliferationReceptor functionEGFHuman gliomas