2024
Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization
Vafaii H, Mandino F, Desrosiers-Grégoire G, O’Connor D, Markicevic M, Shen X, Ge X, Herman P, Hyder F, Papademetris X, Chakravarty M, Crair M, Constable R, Lake E, Pessoa L. Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization. Nature Communications 2024, 15: 229. PMID: 38172111, PMCID: PMC10764905, DOI: 10.1038/s41467-023-44363-z.Peer-Reviewed Original Research
2023
Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb
James S, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Blumenfeld H, Verhagen J, Hyder F, Herman P. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 1891-1904. PMID: 37340791, PMCID: PMC10676132, DOI: 10.1177/0271678x231183887.Peer-Reviewed Original ResearchConceptsVasodilatory responseCerebral cortexNeurovascular couplingOlfactory bulbNeuronal activityBrief sensory stimuliRegional neurovascular couplingStimulus-induced activityHypercapnia challengeVascular toneNeuronal deactivationHemodynamic responseNeuronal excitabilityNeuronal responsesCalcium transientsBrain functionHemodynamic signalsSensory stimuliVasodilationHypercapniaCortexMiceCareful appraisalStimuliMetabolic waste
2022
Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography
Mishra S, Herman P, Crair M, Constable R, Walsh J, Akif A, Verhagen J, Hyder F. Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography. Nanoscale 2022, 14: 17770-17788. PMID: 36437785, PMCID: PMC9850399, DOI: 10.1039/d2nr04878g.Peer-Reviewed Original ResearchConceptsProtein nanoparticlesParamagnetic iron oxide nanoparticlesIron oxide nanoparticlesMagnetic resonance imaging (MRI) contrastRelaxivity ratioOxide nanoparticlesRapid renal clearanceNanoparticlesMRI propertiesImaging contrastMRI contrastCitric acidNeuroscience applicationsFluorescent dyeBlood biochemical assaysUnambiguous detectionRelaxivityCerebral angiographyDyePlatformMajor blood vesselsBiochemical assaysTechnologyBrain capillariesFluorescence angiographyFunctional network properties derived from wide-field calcium imaging differ with wakefulness and across cell type
O’Connor D, Mandino F, Shen X, Horien C, Ge X, Herman P, Hyder F, Crair M, Papademetris X, Lake E, Constable. Functional network properties derived from wide-field calcium imaging differ with wakefulness and across cell type. NeuroImage 2022, 264: 119735. PMID: 36347441, PMCID: PMC9808917, DOI: 10.1016/j.neuroimage.2022.119735.Peer-Reviewed Original Research
2011
Fractal analysis of spontaneous fluctuations of the BOLD signal in rat brain
Herman P, Sanganahalli BG, Hyder F, Eke A. Fractal analysis of spontaneous fluctuations of the BOLD signal in rat brain. NeuroImage 2011, 58: 1060-1069. PMID: 21777682, PMCID: PMC3705180, DOI: 10.1016/j.neuroimage.2011.06.082.Peer-Reviewed Original Research
2010
Hypersensitivity to Thromboxane Receptor Mediated Cerebral Vasomotion and CBF Oscillations during Acute NO-Deficiency in Rats
Horváth B, Lenzsér G, Benyó B, Németh T, Benkő R, Iring A, Hermán P, Komjáti K, Lacza Z, Sándor P, Benyó Z. Hypersensitivity to Thromboxane Receptor Mediated Cerebral Vasomotion and CBF Oscillations during Acute NO-Deficiency in Rats. PLOS ONE 2010, 5: e14477. PMID: 21217826, PMCID: PMC3013104, DOI: 10.1371/journal.pone.0014477.Peer-Reviewed Original ResearchMeSH Keywords15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAnimalsBrainCerebrovascular CirculationEnzyme InhibitorsHypersensitivityLaser-Doppler FlowmetryMaleMiddle Cerebral ArteryMotionNG-Nitroarginine Methyl EsterNitric OxideRatsRats, WistarReceptors, ThromboxaneRho-Associated KinasesSignal TransductionThromboxane A2ConceptsCerebral blood flowCBF oscillationsNitric oxideCerebral vasomotionThromboxane receptorNitro-L-arginine methyl esterDecreased cerebral blood flowMean arterial blood pressureEndothelium-derived nitric oxideTP receptor agonist UAbsence of NOCerebral circulatory parametersLow-frequency spontaneous fluctuationsArterial blood pressureTP receptor activationCerebrovascular toneEndothelial dysfunctionBlood pressureL-NAMEVascular effectsAgonist UNO deficiencyCirculatory parametersPharmacological modulationBlood flow
2009
Cerebral oxygen demand for short‐lived and steady‐state events
Herman P, Sanganahalli BG, Blumenfeld H, Hyder F. Cerebral oxygen demand for short‐lived and steady‐state events. Journal Of Neurochemistry 2009, 109: 73-79. PMID: 19393011, PMCID: PMC2714475, DOI: 10.1111/j.1471-4159.2009.05844.x.Peer-Reviewed Original ResearchOxidative Neuroenergetics in Event-Related Paradigms
Sanganahalli BG, Herman P, Blumenfeld H, Hyder F. Oxidative Neuroenergetics in Event-Related Paradigms. Journal Of Neuroscience 2009, 29: 1707-1718. PMID: 19211878, PMCID: PMC2760964, DOI: 10.1523/jneurosci.5549-08.2009.Peer-Reviewed Original ResearchFractal Characterization of Complexity in Dynamic Signals: Application to Cerebral Hemodynamics
Herman P, Kocsis L, Eke A. Fractal Characterization of Complexity in Dynamic Signals: Application to Cerebral Hemodynamics. Methods In Molecular Biology 2009, 489: 23-40. PMID: 18839086, DOI: 10.1007/978-1-59745-543-5_2.Peer-Reviewed Original ResearchConceptsCerebral hemodynamicsBrain cortexRat brain cortexLaser Doppler flowmetryAge-related stiffeningFunctional magnetic resonanceHemodynamic brain signalsDoppler flowmetryCerebral vasculatureTemporal lobeHuman studiesState of pathologyGray matterParenchymal regionsHemodynamic signalsHemodynamicsHuman brainCortexMagnetic resonanceMedical significance
2008
Frequency‐dependent tactile responses in rat brain measured by functional MRI
Sanganahalli BG, Herman P, Hyder F. Frequency‐dependent tactile responses in rat brain measured by functional MRI. NMR In Biomedicine 2008, 21: 410-416. PMID: 18435491, PMCID: PMC2774500, DOI: 10.1002/nbm.1259.Peer-Reviewed Original Research
2007
Energetics of neuronal signaling and fMRI activity
Maandag NJ, Coman D, Sanganahalli BG, Herman P, Smith AJ, Blumenfeld H, Shulman RG, Hyder F. Energetics of neuronal signaling and fMRI activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20546-20551. PMID: 18079290, PMCID: PMC2154468, DOI: 10.1073/pnas.0709515104.Peer-Reviewed Original ResearchConceptsRSN activityContralateral S1FMRI activationBaseline stateContralateral primary somatosensory cortexPrimary somatosensory cortexSomatosensory cortexIntracortical interactionsFiring rateNeuronal signalingFMRI activityEnsemble activityEnsemble firingStimulationHalothaneCortexNeuronsBaselineActivationFMRI dataLarge majorityAnesthesiaActivityRatsInfluence of the heme-oxygenase pathway on cerebrocortical blood flow
Leszl-Ishiguro M, Horváth B, Johnson R, Johnson F, Lenzsér G, Hermán P, Horváth E, Benyó Z. Influence of the heme-oxygenase pathway on cerebrocortical blood flow. Neuroreport 2007, 18: 1193-1197. PMID: 17589325, DOI: 10.1097/wnr.0b013e3282202459.Peer-Reviewed Original ResearchConceptsCerebrocortical blood flowNitric oxide synthaseEndogenous carbon monoxideBlood flowInhibition of NOSDirect vascular effectsHeme oxygenase pathwayCentral nervous systemNOS blockadeVascular effectsCBF responseOxide synthaseAdult ratsNervous systemHeme oxygenaseBlockadeRatsCurrent studyInhibitionHypercapniaLatter effectHypoxia
2006
Nonlinear Analysis of Blood Cell Flux Fluctuations in the Rat Brain Cortex during Stepwise Hypotension Challenge
Herman P, Eke A. Nonlinear Analysis of Blood Cell Flux Fluctuations in the Rat Brain Cortex during Stepwise Hypotension Challenge. Cerebrovascular And Brain Metabolism Reviews 2006, 26: 1189-1197. PMID: 16395288, DOI: 10.1038/sj.jcbfm.9600266.Peer-Reviewed Original Research
2001
NO Synthase Blockade Induces Chaotic Cerebral Vasomotion via Activation of Thromboxane Receptors
Lacza Z, Hermán P, Görlach C, Hortobágyi T, Sándor P, Wahl M, Benyó Z. NO Synthase Blockade Induces Chaotic Cerebral Vasomotion via Activation of Thromboxane Receptors. Stroke 2001, 32: 2609-2614. PMID: 11692025, DOI: 10.1161/hs1101.098526.Peer-Reviewed Original ResearchConceptsThromboxane receptorL-NACerebral vasomotionThromboxane receptor agonist URat middle cerebral arteriesIntact vesselsGuanylyl cyclase inhibitor 1HNitro-L-arginineMiddle cerebral arteryNO-cGMP pathwayNO donor sodium nitroprussideDonor sodium nitroprussideLack of NOSignificant vasomotionUTP administrationEndothelial dysfunctionSynthase blockadeAgonist UCerebral arteryVascular tensionCerebrovascular diseaseVascular toneCerebral vesselsSynthase inhibitionSodium nitroprussideFractal Branching Pattern in the Pial Vasculature in the Cat
Hermán P, Kocsis L, Eke A. Fractal Branching Pattern in the Pial Vasculature in the Cat. Cerebrovascular And Brain Metabolism Reviews 2001, 21: 741-753. PMID: 11488543, DOI: 10.1097/00004647-200106000-00012.Peer-Reviewed Original Research
2000
Physiological time series: distinguishing fractal noises from motions
Eke A, Hermán P, Bassingthwaighte J, Raymond G, Percival D, Cannon M, Balla I, Ikrényi C. Physiological time series: distinguishing fractal noises from motions. Pflügers Archiv - European Journal Of Physiology 2000, 439: 403-415. PMID: 10678736, DOI: 10.1007/s004249900135.Peer-Reviewed Original Research
1997
Temporal Fluctuations in Regional Red Blood Cell Flux in the Rat Brain Cortex is a Fractal Process
Eke A, Herman P, Bassingthwaighte J, Raymond G, Balla I, Ikrényi C. Temporal Fluctuations in Regional Red Blood Cell Flux in the Rat Brain Cortex is a Fractal Process. Advances In Experimental Medicine And Biology 1997, 428: 703-709. PMID: 9500118, PMCID: PMC4121065, DOI: 10.1007/978-1-4615-5399-1_98.Peer-Reviewed Original Research