2002
Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status
Wagner CA, Finberg KE, Stehberger PA, Lifton RP, Giebisch GH, Aronson PS, Geibel JP. Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status. Kidney International 2002, 62: 2109-2117. PMID: 12427135, DOI: 10.1046/j.1523-1755.2002.00671.x.Peer-Reviewed Original ResearchConceptsPendrin-positive cellsAcid-base statusPositive cellsBicarbonate secretionMouse kidneyAcid-base transportKnockout mouse modelProtein expression levelsMetabolic alkalosisDeficient dietExchanger pendrinPendrin expressionMouse modelSensorineural deafnessThyroid glandBicarbonate loadPendred syndromeWestern blottingApical membraneInner earPendrin proteinControl levelsKidneyPendrinProtein levels
1996
Role of NHE3 in Mediating Renal Brush Border Na+-H+ Exchange ADAPTATION TO METABOLIC ACIDOSIS*
Wu M, Biemesderfer D, Giebisch G, Aronson P. Role of NHE3 in Mediating Renal Brush Border Na+-H+ Exchange ADAPTATION TO METABOLIC ACIDOSIS*. Journal Of Biological Chemistry 1996, 271: 32749-32752. PMID: 8955109, DOI: 10.1074/jbc.271.51.32749.Peer-Reviewed Original ResearchConceptsMetabolic acidosisControl ratsBrush border membraneRenal brush border vesiclesNHE3 proteinBrush border vesiclesBorder membraneBrush borderNHE3 protein expressionRole of NHE3Western blot analysisNormal ratsAcidosisRatsAcidotic ratsRenal brush border membranePharmacologic inhibitorsProtein expressionExchange activityInhibitor sensitivityNHE3Renal brush borderBlot analysisPathways for Oxalate Transport in Rabbit Renal Microvillus Membrane Vesicles*
Kuo S, Aronson P. Pathways for Oxalate Transport in Rabbit Renal Microvillus Membrane Vesicles*. Journal Of Biological Chemistry 1996, 271: 15491-15497. PMID: 8663096, DOI: 10.1074/jbc.271.26.15491.Peer-Reviewed Original Research
1995
Ontogeny of rabbit renal cortical NHE3 and NHE1: effect of glucocorticoids
Baum M, Biemesderfer D, Gentry D, Aronson PS. Ontogeny of rabbit renal cortical NHE3 and NHE1: effect of glucocorticoids. American Journal Of Physiology 1995, 268: f815-f820. PMID: 7771509, DOI: 10.1152/ajprenal.1995.268.5.f815.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, NewbornDexamethasoneIsomerismKidney CortexRabbitsRNA, MessengerSodium-Hydrogen ExchangersConceptsProximal tubulesNHE1 mRNABicarbonate absorptionNHE3 mRNA abundanceDaily subcutaneous administrationAdult animalsAdministration of glucocorticoidsEffects of glucocorticoidsNHE3 protein abundanceNeonatal proximal tubuleDays of ageRenal maturationSubcutaneous administrationRenal cortexNeonatal rabbitsCortical developmentProtein abundanceRate of maturationGlucocorticoidsNHE3 mRNAAntiporter activityApical membraneNHE3Lower ratesTubules
1994
Effects of inhibitors on anion exchangers in rabbit renal brush border membrane vesicles.
McConnell KR, Aronson PS. Effects of inhibitors on anion exchangers in rabbit renal brush border membrane vesicles. Journal Of Biological Chemistry 1994, 269: 21489-21494. PMID: 8063783, DOI: 10.1016/s0021-9258(17)31830-6.Peer-Reviewed Original Research
1993
NHE3: a Na+/H+ exchanger isoform of renal brush border
Biemesderfer D, Pizzonia J, Abu-Alfa A, Exner M, Reilly R, Igarashi P, Aronson PS. NHE3: a Na+/H+ exchanger isoform of renal brush border. American Journal Of Physiology 1993, 265: f736-f742. PMID: 8238556, DOI: 10.1152/ajprenal.1993.265.5.f736.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDNA PrimersFluorescent Antibody TechniqueImmunoblottingImmunohistochemistryKidneyKidney CortexKidney Tubules, ProximalL CellsMiceMicrovilliMolecular Sequence DataMolecular WeightPolymerase Chain ReactionRabbitsRecombinant ProteinsSodium-Hydrogen ExchangersTransfectionConceptsBrush borderRabbit kidneyBrush border membraneProximal tubule cellsRenal brush borderRenal proximal tubulesWestern blot analysisImmune serumProximal tubulesTubule cellsGuinea pigsImmunocytochemical studyRenal brush border membraneKidneyTranscellular reabsorptionExchanger isoformsNHE3Blot analysisFusion proteinSpecific reactivityBasolateral membraneExchanger geneCellsProtein
1991
Cation specificity and modes of the Na+:CO3(2-):HCO3- cotransporter in renal basolateral membrane vesicles
Soleimani M, Lesoine GA, Bergman JA, Aronson PS. Cation specificity and modes of the Na+:CO3(2-):HCO3- cotransporter in renal basolateral membrane vesicles. Journal Of Biological Chemistry 1991, 266: 8706-8710. PMID: 2026588, DOI: 10.1016/s0021-9258(18)31503-5.Peer-Reviewed Original ResearchHigh affinity binding of amiloride analogs at an internal site in renal microvillus membrane vesicles
Desir GV, Cragoe EJ, Aronson PS. High affinity binding of amiloride analogs at an internal site in renal microvillus membrane vesicles. Journal Of Biological Chemistry 1991, 266: 2267-2271. PMID: 1846621, DOI: 10.1016/s0021-9258(18)52238-9.Peer-Reviewed Original ResearchConceptsMembrane vesiclesMicrovillus membrane vesiclesRenal microvillus membrane vesiclesSimilar rank order potencyBinding sitesInternal sitesHigh-affinity inhibitorsMembrane localizationInternal binding siteAmiloride analoguesPlasma membraneRank order potencyHigh-affinity bindingAffinity inhibitorsHigh affinity-binding siteVesiclesBasolateral membrane vesiclesOrder potencyProperties of the renal Na(+)-HCO3- cotransporter.
Aronson PS, Soleimani M, Grassl SM. Properties of the renal Na(+)-HCO3- cotransporter. Seminars In Nephrology 1991, 11: 28-36. PMID: 1900129.Peer-Reviewed Original Research
1989
Effects of acetazolamide on Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex.
Soleimani M, Aronson PS. Effects of acetazolamide on Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Clinical Investigation 1989, 83: 945-951. PMID: 2921327, PMCID: PMC303770, DOI: 10.1172/jci113980.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAcetatesAcetazolamideAmmoniaAnimalsBicarbonatesBiological TransportCarrier ProteinsCell MembraneHydrogen-Ion ConcentrationKidney CortexMaleRabbitsSodiumSodium-Bicarbonate SymportersIdentification and Purification of a Renal Amiloride-binding Protein with Properties of the Na+-H+ Exchanger
Huot SJ, Cassel D, Igarashi P, Cragoe EJ, Slayman CW, Aronson PS. Identification and Purification of a Renal Amiloride-binding Protein with Properties of the Na+-H+ Exchanger. Journal Of Biological Chemistry 1989, 264: 683-686. PMID: 2536021, DOI: 10.1016/s0021-9258(19)84996-7.Peer-Reviewed Original Research
1988
Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles.
Kuo SM, Aronson PS. Oxalate transport via the sulfate/HCO3 exchanger in rabbit renal basolateral membrane vesicles. Journal Of Biological Chemistry 1988, 263: 9710-9717. PMID: 3384817, DOI: 10.1016/s0021-9258(19)81576-4.Peer-Reviewed Original Research4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsAnion Transport ProteinsAntiportersBicarbonatesBiological TransportCarrier ProteinsCell MembraneChloridesElectrochemistryHydrogen-Ion ConcentrationKidney CortexKineticsLactatesLactic AcidMaleMembrane PotentialsOxalatesOxalic AcidPotassiumRabbitsSulfate TransportersSulfatesValinomycin
1987
Anion exchange pathways for Cl- transport in rabbit renal microvillus membranes
Karniski LP, Aronson PS. Anion exchange pathways for Cl- transport in rabbit renal microvillus membranes. American Journal Of Physiology 1987, 253: f513-f521. PMID: 3631282, DOI: 10.1152/ajprenal.1987.253.3.f513.Peer-Reviewed Original ResearchStoichiometry of Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex.
Soleimani M, Grassi SM, Aronson PS. Stoichiometry of Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Clinical Investigation 1987, 79: 1276-1280. PMID: 3558825, PMCID: PMC424331, DOI: 10.1172/jci112948.Peer-Reviewed Original ResearchCovalent modification of the renal Na+/H+ exchanger by N,N'-dicyclohexylcarbodiimide.
Igarashi P, Aronson PS. Covalent modification of the renal Na+/H+ exchanger by N,N'-dicyclohexylcarbodiimide. Journal Of Biological Chemistry 1987, 262: 860-868. PMID: 3027072, DOI: 10.1016/s0021-9258(19)75866-9.Peer-Reviewed Original Research
1986
Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex.
Grassl SM, Aronson PS. Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Biological Chemistry 1986, 261: 8778-8783. PMID: 3013862, DOI: 10.1016/s0021-9258(19)84448-4.Peer-Reviewed Original ResearchInactivation of the renal microvillus membrane Na+-H+ exchanger by histidine-specific reagents.
Grillo FG, Aronson PS. Inactivation of the renal microvillus membrane Na+-H+ exchanger by histidine-specific reagents. Journal Of Biological Chemistry 1986, 261: 1120-1125. PMID: 3003054, DOI: 10.1016/s0021-9258(17)36063-5.Peer-Reviewed Original Research
1985
Chloride/formate exchange with formic acid recycling: a mechanism of active chloride transport across epithelial membranes.
Karniski LP, Aronson PS. Chloride/formate exchange with formic acid recycling: a mechanism of active chloride transport across epithelial membranes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 6362-6365. PMID: 3862136, PMCID: PMC391054, DOI: 10.1073/pnas.82.18.6362.Peer-Reviewed Original ResearchParadoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes.
Guggino SE, Aronson PS. Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes. Journal Of Clinical Investigation 1985, 76: 543-547. PMID: 4031062, PMCID: PMC423858, DOI: 10.1172/jci112004.Peer-Reviewed Original ResearchConceptsLow dosesParadoxical effectUrate transportProximal tubular cellsUrate accumulationRenal urate excretionCanine renal cortexUrate retentionInside-alkaline pH gradientUricosuric drugsUrate reabsorptionRenal cortexUrate excretionTubular cellsHigh dosesCotransport pathwayDosesSame transport systemPyrazinoateLuminal membraneUrate uptakeAnion exchange pathwayDrugsMicrovillus membrane vesicles
1984
Absence of Cl-OH exchange and NaCl cotransport in rabbit renal microvillus membrane vesicles
Seifter JL, Knickelbein R, Aronson PS. Absence of Cl-OH exchange and NaCl cotransport in rabbit renal microvillus membrane vesicles. American Journal Of Physiology 1984, 247: f753-f759. PMID: 6093589, DOI: 10.1152/ajprenal.1984.247.5.f753.Peer-Reviewed Original Research