2004
WNK4 regulates apical and basolateral Cl– flux in extrarenal epithelia
Kahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, Aronson PS, Lifton RP. WNK4 regulates apical and basolateral Cl– flux in extrarenal epithelia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 2064-2069. PMID: 14769928, PMCID: PMC357052, DOI: 10.1073/pnas.0308434100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCarrier ProteinsCell PolarityChloridesEpitheliumHumansImmunohistochemistryIon TransportKidneyMembrane ProteinsMembrane Transport ProteinsMiceOocytesProtein Serine-Threonine KinasesRNA, MessengerSodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2Sulfate TransportersXenopus laevisConceptsCl fluxBlood-brain barrierUnrelated ion channelsActivity of mediatorsWNK4 mRNABile ductPancreatic ductExtrarenal expressionExtrarenal tissuesCl(-) handlingPseudohypoaldosteronism type IIChannel ROMKNaCl reabsorptionSerine-threonine kinase WNK4Specialized endotheliumExchanger SLC26A6NaCl cotransporterWNK4 effectsColonic cryptsEpitheliumVariable inhibitionSweat ductsTight junctionsKidneyElectrolyte flux
2002
Renal expression of novel Na+/H+exchanger isoform NHE8
Goyal S, Heuvel G, Aronson PS. Renal expression of novel Na+/H+exchanger isoform NHE8. American Journal Of Physiology. Renal Physiology 2002, 284: f467-f473. PMID: 12409279, DOI: 10.1152/ajprenal.00352.2002.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibody SpecificityCation Transport ProteinsCOS CellsDrosophila ProteinsHumansImmunoblottingIn Situ HybridizationKidneyMembrane ProteinsMiceMicrovilliMolecular Sequence DataOrgan SpecificityProtein IsoformsRatsRNA, MessengerSequence AlignmentSequence Analysis, DNASequence Homology, Amino AcidSodium-Hydrogen Exchanger 1Sodium-Hydrogen ExchangersTransfectionConceptsProximal tubulesComplete open reading frameProximal tubule localizationRat renal cortexAmino acid identityOpen reading frameRenal expressionCortical tubulesRenal cortexOuter stripeOuter medullaNull miceMammalian orthologsWestern blotDrosophila melanogasterMouse kidneyMedullaMembrane ion transportProtein expressionAcid identityNHE8CortexMammalian isoformsReading frameNHE isoforms
1998
cDNA Cloning and Chromosomal Localization of the Human and Mouse Isoforms of Ksp-Cadherin
Thomson RB, Ward DC, Quaggin SE, Igarashi P, Muckler ZE, Aronson PS. cDNA Cloning and Chromosomal Localization of the Human and Mouse Isoforms of Ksp-Cadherin. Genomics 1998, 51: 445-451. PMID: 9721215, DOI: 10.1006/geno.1998.5402.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCadherinsCell Adhesion MoleculesChromosome MappingChromosomes, Human, Pair 16Cloning, MolecularHumansIn Situ Hybridization, FluorescenceKidneyMiceMice, Inbred StrainsMolecular Sequence DataMultigene FamilyRNA, MessengerSequence Analysis, DNASequence Homology, Amino AcidConceptsMouse isoformsKsp-cadherinPutative N-glycosylation sitesInferred amino acid sequenceSingle ancestral geneCharacteristic protein domainsCadherin family membersKidney-specific memberN-glycosylation sitesAmino acid sequenceMammalian genomesAncestral geneGene duplicationSyntenic regionsChromosomal localizationComplete cDNAGene mapsProtein domainsSequence motifsGene sequencesCDNA cloningCell adhesion moleculeAcid sequenceNorthern analysisChromosome 8
1995
Ontogeny of rabbit renal cortical NHE3 and NHE1: effect of glucocorticoids
Baum M, Biemesderfer D, Gentry D, Aronson PS. Ontogeny of rabbit renal cortical NHE3 and NHE1: effect of glucocorticoids. American Journal Of Physiology 1995, 268: f815-f820. PMID: 7771509, DOI: 10.1152/ajprenal.1995.268.5.f815.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, NewbornDexamethasoneIsomerismKidney CortexRabbitsRNA, MessengerSodium-Hydrogen ExchangersConceptsProximal tubulesNHE1 mRNABicarbonate absorptionNHE3 mRNA abundanceDaily subcutaneous administrationAdult animalsAdministration of glucocorticoidsEffects of glucocorticoidsNHE3 protein abundanceNeonatal proximal tubuleDays of ageRenal maturationSubcutaneous administrationRenal cortexNeonatal rabbitsCortical developmentProtein abundanceRate of maturationGlucocorticoidsNHE3 mRNAAntiporter activityApical membraneNHE3Lower ratesTubules