1985
Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes.
Guggino SE, Aronson PS. Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes. Journal Of Clinical Investigation 1985, 76: 543-547. PMID: 4031062, PMCID: PMC423858, DOI: 10.1172/jci112004.Peer-Reviewed Original ResearchConceptsLow dosesParadoxical effectUrate transportProximal tubular cellsUrate accumulationRenal urate excretionCanine renal cortexUrate retentionInside-alkaline pH gradientUricosuric drugsUrate reabsorptionRenal cortexUrate excretionTubular cellsHigh dosesCotransport pathwayDosesSame transport systemPyrazinoateLuminal membraneUrate uptakeAnion exchange pathwayDrugsMicrovillus membrane vesicles
1983
Urate transport via anion exchange in dog renal microvillus membrane vesicles
Kahn AM, Aronson PS. Urate transport via anion exchange in dog renal microvillus membrane vesicles. American Journal Of Physiology 1983, 244: f56-f63. PMID: 6849384, DOI: 10.1152/ajprenal.1983.244.1.f56.Peer-Reviewed Original ResearchConceptsDose-response curveP-aminohippurateUrate transportRenal microvillus membrane vesiclesUptake of PAHDog renal cortexMicrovillus membrane vesiclesAnion reabsorptionRenal cortexProximal tubulesTransport of urateUrateBrush border membrane vesiclesMembrane vesiclesUrate uptakePAH uptakeExternal ClPresent studyBorder membrane vesicles