2012
Urinary Metabolic Phenotyping the slc26a6 (Chloride–Oxalate Exchanger) Null Mouse Model
Garcia-Perez I, Villaseñor A, Wijeyesekera A, Posma JM, Jiang Z, Stamler J, Aronson P, Unwin R, Barbas C, Elliott P, Nicholson J, Holmes E. Urinary Metabolic Phenotyping the slc26a6 (Chloride–Oxalate Exchanger) Null Mouse Model. Journal Of Proteome Research 2012, 11: 4425-4435. PMID: 22594923, PMCID: PMC4028149, DOI: 10.1021/pr2012544.Peer-Reviewed Original ResearchConceptsRenal stone diseaseStone diseaseNull miceUrinary metabolic signaturesBlood pressure controlWild-type miceNull mouse modelRenal stone formationRenal proximal tubulesUrinary metabolicUrinary metabolomeClear metabolic differentiationSodium homeostasisRenal stonesType miceMouse modelUrinary metabolitesOxalate balanceUrinary profilesProximal tubulesPressure controlStone formationExchanger SLC26A6Metabolic signaturesPathological processes
2006
Regulation of anion exchanger Slc26a6 by protein kinase C
Hassan HA, Mentone S, Karniski LP, Rajendran VM, Aronson PS. Regulation of anion exchanger Slc26a6 by protein kinase C. American Journal Of Physiology - Cell Physiology 2006, 292: c1485-c1492. PMID: 17151144, DOI: 10.1152/ajpcell.00447.2006.Peer-Reviewed Original ResearchMeSH KeywordsAcetophenonesAnimalsAnion Transport ProteinsAntiportersBenzopyransBiological Transport, ActiveCarbazolesCell MembraneChloridesCytoplasmEnzyme ActivationFemaleFormatesIn Vitro TechniquesIndolesMaleimidesMiceOocytesOxalatesProtein Kinase C-deltaProtein TransportSulfate TransportersTetradecanoylphorbol AcetateXenopusConceptsPKC activationOxalate secretionIntestinal oxalate secretionFormate exchangeRenal proximal tubulesAnion exchanger pendrinPancreatic ductExchanger pendrinProximal tubulesSmall intestineSLC26A6 expressionNaCl reabsorptionCalcium independentSimilar extentPotential rolePKC-delta activationProtein kinase CActivationSecretionSlc26a6Immunofluorescence microscopyXenopus oocytesPMAPhysiological significanceOocyte plasma membraneIon exchangers mediating Na+, HCO3 - and Cl- transport in the renal proximal tubule.
Aronson PS. Ion exchangers mediating Na+, HCO3 - and Cl- transport in the renal proximal tubule. Journal Of Nephrology 2006, 19 Suppl 9: s3-s10. PMID: 16736438.Commentaries, Editorials and LettersConceptsProximal tubulesNaCl absorptionApical membrane ClNull miceOxalate-sulfate exchangePendrin-null miceProximal tubule cellsBrush borderFormate exchangeRenal proximal tubulesSlc26a6-null miceAcid secretionPendrin expressionFunctional expression studiesTubule cellsNaCl reabsorptionCl absorptionBrush border membraneSulfate cotransportLines of evidenceExchanger isoformsTubulesMiceFamily membersBorder membrane
2002
Ion exchangers mediating NaCl transport in the renal proximal tubule
Aronson PS. Ion exchangers mediating NaCl transport in the renal proximal tubule. Cell Biochemistry And Biophysics 2002, 36: 147-153. PMID: 12139400, DOI: 10.1385/cbb:36:2-3:147.Commentaries, Editorials and LettersConceptsProximal tubulesNaCl absorptionOxalate-sulfate exchangeLoop of HenleProximal tubule cellsNaCl transportRenal proximal tubulesRecycling of formateRole of NHE3NHE3 null miceTubule cellsNull micePerfusion solutionNephron segmentsIsoform-specific antibodiesApical membraneRenal brush border vesiclesMammalian proximal tubuleBrush border vesiclesSulfate cotransportBrush border membrane vesiclesTubulesFormate exchangeNHE3Stimulation
1997
Sodium-hydrogen exchange isoform expression in blood cells: implications for studies in diabetes mellitus
Rutherford P, Pizzonia J, Abu-Alfa A, Biemesderfer D, Reilly R, Aronson P. Sodium-hydrogen exchange isoform expression in blood cells: implications for studies in diabetes mellitus. Experimental And Clinical Endocrinology & Diabetes 1997, 105: 13-16. PMID: 9288535, DOI: 10.1055/s-0029-1211787.Peer-Reviewed Original ResearchConceptsPeripheral blood cellsPeripheral blood cell preparationsDiabetes mellitusBlood cell preparationsBlood cellsNHE activityPathophysiological roleNa-H exchange activityNHE-1Vascular smooth muscle cell proliferationNHE-3Smooth muscle cell proliferationProgressive renal impairmentNHE isoformsVascular smooth muscleDirect pathophysiological roleCell preparationsMuscle cell proliferationPlatelet membranesNa-H exchangeRenal proximal tubulesNHE isoforms 1Sodium-hydrogen exchangeRenal impairmentNondiabetic controls
1993
NHE3: a Na+/H+ exchanger isoform of renal brush border
Biemesderfer D, Pizzonia J, Abu-Alfa A, Exner M, Reilly R, Igarashi P, Aronson PS. NHE3: a Na+/H+ exchanger isoform of renal brush border. American Journal Of Physiology 1993, 265: f736-f742. PMID: 8238556, DOI: 10.1152/ajprenal.1993.265.5.f736.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDNA PrimersFluorescent Antibody TechniqueImmunoblottingImmunohistochemistryKidneyKidney CortexKidney Tubules, ProximalL CellsMiceMicrovilliMolecular Sequence DataMolecular WeightPolymerase Chain ReactionRabbitsRecombinant ProteinsSodium-Hydrogen ExchangersTransfectionConceptsBrush borderRabbit kidneyBrush border membraneProximal tubule cellsRenal brush borderRenal proximal tubulesWestern blot analysisImmune serumProximal tubulesTubule cellsGuinea pigsImmunocytochemical studyRenal brush border membraneKidneyTranscellular reabsorptionExchanger isoformsNHE3Blot analysisFusion proteinSpecific reactivityBasolateral membraneExchanger geneCellsProtein