2007
Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cells
Zhang J, Bobulescu IA, Goyal S, Aronson PS, Baum MG, Moe OW. Characterization of Na+/H+ exchanger NHE8 in cultured renal epithelial cells. American Journal Of Physiology. Renal Physiology 2007, 293: f761-f766. PMID: 17581925, PMCID: PMC2861566, DOI: 10.1152/ajprenal.00117.2007.Peer-Reviewed Original ResearchConceptsNRK cellsBasolateral NHE activityNHE8 proteinApical membraneNHE1 protein levelsPrimary amino acid sequenceAmino acid sequenceProtein levelsProtein expressionNHE8 protein expressionBasolateral membraneCultured renal epithelial cellsRenal epithelial cellsMammalian cellsNHE activityFunctional characterizationPlasma membraneAcid sequenceRenal cell linesNHE1 protein expressionNative environmentImmunoelectron microscopyExchange activityCell linesNHE8
2002
Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy
Knauf F, Rogina B, Jiang Z, Aronson PS, Helfand SL. Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 14315-14319. PMID: 12391301, PMCID: PMC137881, DOI: 10.1073/pnas.222531899.Peer-Reviewed Original ResearchConceptsPlasma membraneLife-extending mutationsNew longevity genesIntermediary metabolismAdult fat bodyIndy expressionCitric acid cycleLife-extending effectsMetabolite transportersVariety of speciesLongevity genesFunctional characterizationLife spanMidgut cellsFat bodyAcid cycleFunctional studiesXenopus oocytesTransport functionIndyBasolateral regionSodium-independent mechanismProminent expressionAverage life spanTransporters