2006
Rapid Hypoxia Preconditioning Protects Cortical Neurons From Glutamate Toxicity Through δ-Opioid Receptor
Zhang J, Qian H, Zhao P, Hong SS, Xia Y. Rapid Hypoxia Preconditioning Protects Cortical Neurons From Glutamate Toxicity Through δ-Opioid Receptor. Stroke 2006, 37: 1094-1099. PMID: 16514101, DOI: 10.1161/01.str.0000206444.29930.18.Peer-Reviewed Original ResearchConceptsDelta-opioid receptorsHypoxia preconditioningCortical neuronsNeuronal injuryGlutamate-induced neuronal injuryCultured rat cortical neuronsReceptor bindingSevere hypoxic injurySevere neuronal injuryRT-PCRCultured cortical neuronsMRNA levelsNMDA receptor expressionRat cortical neuronsΔ-opioid receptorsDOR mRNA levelsCulture day 8Short-term hypoxiaDOR mRNALactate dehydrogenase leakageHypoxic injuryGlutamate toxicityNeuronal viabilityReceptor expressionNeuroprotection
2005
Oxygen-sensitive δ-Opioid Receptor-regulated Survival and Death Signals NOVEL INSIGHTS INTO NEURONAL PRECONDITIONING AND PROTECTION*
Ma M, Qian H, Ghassemi F, Zhao P, Xia Y. Oxygen-sensitive δ-Opioid Receptor-regulated Survival and Death Signals NOVEL INSIGHTS INTO NEURONAL PRECONDITIONING AND PROTECTION*. Journal Of Biological Chemistry 2005, 280: 16208-16218. PMID: 15687501, DOI: 10.1074/jbc.m408055200.Peer-Reviewed Original ResearchConceptsDelta-opioid receptorsHPC protectionSevere hypoxiaSpecific signaling pathwaysCytochrome c releaseP38 MAPK activityKinase C pathwayBcl-2 activityMembrane proteinsC releaseMAPK activityMolecular mechanismsSignaling pathwaysΔ-opioid receptorsP38 MAPKNovel insightsNovel mechanismC pathwayNeuronal injuryDOR antagonistDOR mRNAProtein levelsDOR expressionIschemic disordersNeuronal preconditioning