miRNA Regulatory Circuits in ES Cells Differentiation: A Chemical Kinetics Modeling Approach
Luo Z, Xu X, Gu P, Lonard D, Gunaratne PH, Cooney AJ, Azencott R. miRNA Regulatory Circuits in ES Cells Differentiation: A Chemical Kinetics Modeling Approach. PLOS ONE 2011, 6: e23263. PMID: 22039400, PMCID: PMC3198445, DOI: 10.1371/journal.pone.0023263.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell DifferentiationEmbryonic Stem CellsKineticsMiceMicroRNAsModels, BiologicalOligonucleotide Array Sequence AnalysisTranscription, GeneticConceptsES cell differentiationMRNA genesRepressive interactionsCell differentiationTarget mRNA genesEmbryonic stem cellsGene regulationRegulatory circuitsTranslation inhibitionMRNA targetsGene MES cellsMiRNAs inhibitorsMicroarray dataGenesMiRNAsStem cellsGene GProtein expressionDirect degradationMRNADifferentiationImportant roleCellsMicroRNAs