The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons
Chung CY, Licznerski P, Alavian KN, Simeone A, Lin Z, Martin E, Vance J, Isacson O. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain 2010, 133: 2022-2031. PMID: 20573704, PMCID: PMC2892944, DOI: 10.1093/brain/awq142.Peer-Reviewed Original ResearchConceptsMidbrain dopaminergic neuronsVentral mesencephalic culturesTranscription factor orthodenticle homeobox 2Orthodenticle homeobox 2Dopaminergic neuronsMesencephalic culturesShort hairpin RNAHomeobox 2A10 dopaminergic neuronsCyclase-activating peptideHairpin RNAConditional knockout miceVentral mesencephalonNeuronal vulnerabilityDopaminergic projectionsAxonal projectionsParkinson's diseaseAdult miceKnockout miceMN9D cellsNeuropilin-2Elevated geneNeuronsNeuropilin-1Human midbrain