2012
Enhanced Anti-Serpin Antibody Activity Inhibits Autoimmune Inflammation in Type 1 Diabetes
Czyzyk J, Henegariu O, Preston-Hurlburt P, Baldzizhar R, Fedorchuk C, Esplugues E, Bottomly K, Gorus FK, Herold K, Flavell RA. Enhanced Anti-Serpin Antibody Activity Inhibits Autoimmune Inflammation in Type 1 Diabetes. The Journal Of Immunology 2012, 188: 6319-6327. PMID: 22593614, PMCID: PMC3370061, DOI: 10.4049/jimmunol.1200467.Peer-Reviewed Original ResearchConceptsAutoimmune diabetes-prone NOD miceDiabetes-prone NOD miceHuman type 1 diabetesAnti-insulin autoantibodiesOnset of diabetesProtective humoral immunityType 1 diabetesNOD miceAutoimmune inflammationIslet inflammationNOD modelSuboptimal doseAutoimmune diseasesHumoral immunityImmunological toleranceT cellsHumoral activityType 1Early onsetDiabetesElevated levelsClade B serpinsAutoantibodiesInflammationProtease inhibitors
2011
TH17 cells mediate pulmonary collateral priming
Albrecht M, Chen HC, Preston-Hurlburt P, Ranney P, Hoymann HG, Maxeiner J, Staudt V, Taube C, Bottomly HK, Dittrich AM. TH17 cells mediate pulmonary collateral priming. Journal Of Allergy And Clinical Immunology 2011, 128: 168-177.e8. PMID: 21459426, PMCID: PMC3129446, DOI: 10.1016/j.jaci.2011.01.067.Peer-Reviewed Original ResearchConceptsCollateral primingAirway inflammationNew antigensAirway hyperresponsivenessIL-17AT cellsMemory/effector phenotypeCognate antigenLymphocytic airway inflammationStronger airway hyperresponsivenessIL-17A secretionEndogenous T cellsAirway responsivenessIgG2a levelsOngoing inflammationTh17 cellsAllergic sensitizationLymphocytic inflammationEffector phenotypePulmonary inflammationInflammatory phenotypeUnrelated antigensMurine modelInflammationCongenic mice