Use of CART cells to selectively target autoantigen-specific T cells for the treatment of autoimmune diabetes
Yu H, Bettini M, Ellis G, Riley J, Collins J, Preston-Hurlburt P, Korah M, Mallone R, Deng S, Wang X, Fremont D, Spiegel D, Cresswell P, Herold K. Use of CART cells to selectively target autoantigen-specific T cells for the treatment of autoimmune diabetes. The Journal Of Immunology 2020, 204: 238.8-238.8. DOI: 10.4049/jimmunol.204.supp.238.8.Peer-Reviewed Original ResearchCART cellsT cellsAutoimmune diabetesCAR constructsHuman antigen-specific CD8Autoantigen-specific T cellsAntigen-specific CD8Pathogenic T cellsPrevious clinical trialsΒ-cell damageChimeric antigen receptorNon-specific actionT cell linesHuman T cellsDominant cell typeHuman insulitisPathogenic subpopulationsNovel immunotherapiesPrimary human T cellsClinical trialsPrimary mediatorPeptide epitopesAntigen receptorMicroglobulin complexCAR signalingHSV-2 infects T follicular helper cells to promote HIV reactivation
Pierce C, Loh L, Preston-Hurlburt P, Herold K, Herold B. HSV-2 infects T follicular helper cells to promote HIV reactivation. The Journal Of Immunology 2020, 204: 247.24-247.24. DOI: 10.4049/jimmunol.204.supp.247.24.Peer-Reviewed Original ResearchCD4 T cellsFollicular helper cellsHIV reactivationHSV-2T cellsTfh cellsIL-32Helper cellsSystemic effectsCD4 T-cell subpopulationsT Follicular Helper CellsHSV-2 recurrencesHSV-2 seropositiveT cell subpopulationsGlobal HIV epidemicPotential systemic effectsT cell linesSeronegative womenIL-32γHigh HIVViral loadHIV transmissionLatent HIVProinflammatory cytokinesHIV epidemic