Circulating activin A is a novel prognostic biomarker in malignant pleural mesothelioma – A multi-institutional study
Hoda MA, Dong Y, Rozsas A, Klikovits T, Laszlo V, Ghanim B, Stockhammer P, Ozsvar J, Jakopovic M, Samarzija M, Brcic L, Bendek M, Szirtes I, Reid G, Kirschner MB, Kao SC, Opitz I, Weder W, Frauenfelder T, Nguyen-Kim TD, Aigner C, Klepetko W, van Zandwijk N, Berger W, Dome B, Grusch M, Hegedus B. Circulating activin A is a novel prognostic biomarker in malignant pleural mesothelioma – A multi-institutional study. European Journal Of Cancer 2016, 63: 64-73. PMID: 27288871, DOI: 10.1016/j.ejca.2016.04.018.Peer-Reviewed Original ResearchMeSH KeywordsActivinsAgedBiomarkers, TumorEnzyme-Linked Immunosorbent AssayFemaleFibrinogenHumansLung NeoplasmsMaleMesotheliomaMesothelioma, MalignantMiddle AgedPleural NeoplasmsPrognosisConceptsMalignant pleural mesotheliomaActivin A levelsMPM patientsActivin APleural mesotheliomaHigh activin A levelsNon-malignant pleural diseaseEpithelioid malignant pleural mesotheliomaEpithelioid MPM patientsTime of diagnosisLonger overall survivalNovel prognostic biomarkerMulti-institutional studyEnzyme-linked immunosorbent assayA levelsPlasma activinOverall survivalSurgical resectionActivin expressionHigh activinPleural diseasePoor prognosisClinicopathological variablesEpithelioid histologyHealthy controls