2020
Tumour cell PD-L1 expression is prognostic in patients with malignant pleural effusion: the impact of C-reactive protein and immune-checkpoint inhibition
Ghanim B, Rosenmayr A, Stockhammer P, Vogl M, Celik A, Bas A, Kurul IC, Akyurek N, Varga A, Plönes T, Bankfalvi A, Hager T, Schuler M, Hackner K, Errhalt P, Scheed A, Seebacher G, Hegedus B, Stubenberger E, Aigner C. Tumour cell PD-L1 expression is prognostic in patients with malignant pleural effusion: the impact of C-reactive protein and immune-checkpoint inhibition. Scientific Reports 2020, 10: 5784. PMID: 32238865, PMCID: PMC7113285, DOI: 10.1038/s41598-020-62813-2.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitionC-reactive proteinMalignant pleural effusionKi-67 indexPD-L1Overall survivalPleural effusionPrognostic powerPD-L1 tumor proportion scoreNegative PD-L1 statusPD-L1 positive tumorsLonger median OSMedian overall survivalPD-L1 expressionPD-L1 statusTumor proportion scoreFurther prospective validationVariety of malignanciesICI therapyMedian OSSignificant prognosticatorShorter OSIndependent prognosticatorPrognostic roleDismal prognosis
2019
PD-L1 and Ki67 are prognostic in malignant pleural effusion – a retrospective international multicenter study
Ghanim B, Rosenmayr A, Vogl M, Celik A, Bas A, Kurul I, Akyurek N, Varga A, Aigner C, Plönes T, Hegedüs B, Stockhammer P, Hackner K, Errhalt P, Scheed A, Seebacher G, Stubenberger E. PD-L1 and Ki67 are prognostic in malignant pleural effusion – a retrospective international multicenter study. Zentralblatt Für Chirurgie - Zeitschrift Für Allgemeine Viszeral- Thorax- Und Gefäßchirurgie 2019, 144: s92-s92. DOI: 10.1055/s-0039-1694203.Peer-Reviewed Original Research