2013
Neuroprotective Role of a Brain-Enriched Tyrosine Phosphatase, STEP, in Focal Cerebral Ischemia
Deb I, Manhas N, Poddar R, Rajagopal S, Allan AM, Lombroso PJ, Rosenberg GA, Candelario-Jalil E, Paul S. Neuroprotective Role of a Brain-Enriched Tyrosine Phosphatase, STEP, in Focal Cerebral Ischemia. Journal Of Neuroscience 2013, 33: 17814-17826. PMID: 24198371, PMCID: PMC3818554, DOI: 10.1523/jneurosci.2346-12.2013.Peer-Reviewed Original ResearchConceptsIschemic brain damageStriatal-enriched phosphataseBrain damageNeuroprotective roleBrain injuryP38 MAPK activationSustained p38 MAPK activationIschemic brain injuryFocal cerebral ischemiaOnset of reperfusionHypoxia-reoxygenation injuryP38 MAPKMAPK activationIschemic strokeNeurological deficitsCerebral ischemiaStroke therapyKO miceRat modelP38 MAPK pathwayCultured neuronsNeuronal culturesGenetic deletionSecondary activationInjury
1999
Hypoxia‐Ischemia in Perinatal Rat Brain Induces the Formation of a Low Molecular Weight Isoform of Striatal Enriched Tyrosine Phosphatase (STEP)
Gurd J, Bissoon N, Nguyen T, Lombroso P, Rider C, Beesley P, Vannucci S. Hypoxia‐Ischemia in Perinatal Rat Brain Induces the Formation of a Low Molecular Weight Isoform of Striatal Enriched Tyrosine Phosphatase (STEP). Journal Of Neurochemistry 1999, 73: 1990-1994. PMID: 10537057, DOI: 10.1046/j.1471-4159.1999.01990.x.Peer-Reviewed Original ResearchConceptsHypoxia-ischemiaP21 ratsRat brainIschemia-induced elevationP21 rat brainUnilateral hypoxia-ischemiaCerebral hypoxia-ischemiaPerinatal rat brainResult of ischemiaCalcium-dependent proteolysisLow molecular weight isoformsInterval of recoveryP7 ratsContralateral sideMolecular weight isoformsNT2/D1 cellsCalcium ionophoreLow Mr isoformPostsynaptic densityRatsBrainCalpain IWeight isoformsIschemiaPhosphorylation levels