2014
Comparative pharmacodynamics of pancuronium, cisatracurium, and CW002 in rabbits.
Diaz LL, Zhang J, Heerdt PM. Comparative pharmacodynamics of pancuronium, cisatracurium, and CW002 in rabbits. Journal Of The American Association For Laboratory Animal Science 2014, 53: 283-9. PMID: 24827571, PMCID: PMC4128567.Peer-Reviewed Original ResearchConceptsNeuromuscular blocking drugsRecovery indexNew Zealand white rabbitsPotential side effectsCross-over designZealand white rabbitsComparative PharmacodynamicsBlocking drugsPharmacologic reversalMuscle twitchCisatracuriumPancuroniumAnesthetized rabbitsSide effectsCW002Cholinergic manipulationsSurvival proceduresSimilar onsetWhite rabbitsEffective doseSurvival studiesLonger durationDrugsRabbitsTime course
2000
Isoflurane Pretreatment Ameliorates Postischemic Neurologic Dysfunction and Preserves Hippocampal Ca2+/Calmodulin-dependent Protein Kinase in a Canine Cardiac Arrest Model
Blanck T, Haile M, Xu F, Zhang J, Heerdt P, Veselis R, Beckman J, Kang R, Adamo A, Hemmings H. Isoflurane Pretreatment Ameliorates Postischemic Neurologic Dysfunction and Preserves Hippocampal Ca2+/Calmodulin-dependent Protein Kinase in a Canine Cardiac Arrest Model. Anesthesiology 2000, 93: 1285-1293. PMID: 11046218, DOI: 10.1097/00000542-200011000-00023.Peer-Reviewed Original ResearchMeSH KeywordsAnesthetics, InhalationAnimalsBlood PressureBlotting, WesternBrain DiseasesCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium-Calmodulin-Dependent Protein KinasesDogsFemaleHeart Arrest, InducedHeart RateHippocampusIschemic Attack, TransientIschemic PreconditioningIsofluraneNeuroprotective AgentsSynaptosomesConceptsNeurologic deficit scoreCanine cardiac arrest modelCardiac arrest modelDeficit scoresIschemic animalsCardiac arrestGlobal ischemiaStriatum of animalsEffective neuroprotective drugsIsoflurane pretreatmentNeurologic dysfunctionNeurologic functionHippocampal contentNeuroprotective effectsIsoflurane exposureHippocampal levelsIntensive careNeuroprotective drugsRat modelVentricular fibrillationInhalational anestheticsTreatment groupsBlinded evaluatorsCanine modelIschemia
1998
Disparity of isoflurane effects on left and right ventricular afterload and hydraulic power generation in swine.
Heerdt P, Gandhi C, Dickstein M. Disparity of isoflurane effects on left and right ventricular afterload and hydraulic power generation in swine. Anesthesia & Analgesia 1998, 87: 511-21. PMID: 9728819, DOI: 10.1097/00000539-199809000-00002.Peer-Reviewed Original ResearchConceptsPreload recruitable stroke work slopeDose-related decreaseRight ventricleLeft ventricleISO groupMinimum alveolar anesthetic concentration (MAC) isofluraneIso animalsPulmonary arterial blood flowIsoflurane-induced alterationsRight ventricular afterloadTotal arterial resistanceDose-related effectsEffects of isofluranePeak systolic pressureAutonomic nervous activityArterial blood flowGroups of swineRegional segment lengthVolatile Anesthetic EffectsEjection of bloodBiventricular contractilityRV contractilityVascular effectsVentricular afterloadSystolic pressureDisparity of Isoflurane Effects on Left and Right Ventricular Afterload and Hydraulic Power Generation in Swine
Heerdt P, Gandhi C, Dickstein M. Disparity of Isoflurane Effects on Left and Right Ventricular Afterload and Hydraulic Power Generation in Swine. Anesthesia & Analgesia 1998, 87: 511-521.. DOI: 10.1213/00000539-199809000-00002.Peer-Reviewed Original ResearchConceptsPreload recruitable stroke work slopeDose-related decreaseRight ventricleLeft ventricleISO groupMinimum alveolar anesthetic concentration (MAC) isofluraneIso animalsPulmonary arterial blood flowIsoflurane-induced alterationsTotal arterial resistanceDose-related effectsEffects of isofluranePeak systolic pressureAutonomic nervous activityArterial blood flowGroups of swineRegional segment lengthVolatile Anesthetic EffectsEjection of bloodBiventricular contractilityRV contractilityVascular effectsVentricular afterloadSystolic pressureLV afterload