2006
Cardiomyopathic Etiology and SERCA2a Reverse Remodeling During Mechanical Support of the Failing Human Heart
Heerdt PM, Klotz S, Burkhoff D. Cardiomyopathic Etiology and SERCA2a Reverse Remodeling During Mechanical Support of the Failing Human Heart. Anesthesia & Analgesia 2006, 102: 32-37. PMID: 16368801, DOI: 10.1213/01.ane.0000183642.09435.ad.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAnimalsBiomechanical PhenomenaCalcium-Transporting ATPasesCardiomyopathy, DilatedConfidence IntervalsDatabases, FactualFemaleGene Expression Regulation, EnzymologicHeart-Assist DevicesHumansIn Vitro TechniquesMaleMiddle AgedRatsSarcoplasmic Reticulum Calcium-Transporting ATPasesVentricular RemodelingConceptsLeft ventricular assist deviceForce-frequency relationshipSERCA2a functionMyocardial force-frequency relationshipMyocyte calcium cyclingSERCA2a gene expressionFailing Human HeartVentricular assist deviceChronic failureProportion of trabeculaeReverse remodelingLVAD supportMyopathic originSubtype 2aDCM heartsDisease processSERCA2a mRNAAssist deviceCalcium cyclingHeart samplesAbnormal expressionMyocardial trabeculaeGene expressionMolecular remodelingHuman heart
2005
Anesthetic-Induced Alteration in Expression of Myocardial Calcium Cycling Proteins
Heerdt PM, H.S. The A, Markov NP. Anesthetic-Induced Alteration in Expression of Myocardial Calcium Cycling Proteins. Journal Of Cardiothoracic And Vascular Anesthesia 2005, 19: 340-344. PMID: 16130061, DOI: 10.1053/j.jvca.2005.02.007.Peer-Reviewed Original ResearchConceptsCalcium cycling proteinsCycling proteinsSarcolemmal sodium-calcium exchangerMolecular remodelingInduction of anesthesiaNew Zealand white rabbitsEnd-tidal halothaneGroups of rabbitsZealand white rabbitsSodium-calcium exchangerHalothane doseWestern blot analysisPerioperative interventionsTracheal intubationUniversity research laboratorySubtype 2aPrior treatmentWhite rabbits