2014
Regulation of Protein Phosphatase 1I by Cdc25C-associated Kinase 1 (C-TAK1) and PFTAIRE Protein Kinase*
Platholi J, Federman A, Detert JA, Heerdt P, Hemmings HC. Regulation of Protein Phosphatase 1I by Cdc25C-associated Kinase 1 (C-TAK1) and PFTAIRE Protein Kinase*. Journal Of Biological Chemistry 2014, 289: 23893-23900. PMID: 25028520, PMCID: PMC4156073, DOI: 10.1074/jbc.m114.557744.Peer-Reviewed Original ResearchConceptsProtein phosphatase 1IC-TAK1Protein kinaseKinase 1GSK-3Protein phosphatase 1Phosphatase activityPP-1cThr-72Multisite phosphorylationActivating residuesPhosphatase 1Regulatory subunitSer-86Ser-71Subsequent phosphorylationMajor endogenous formsInhibitor 2PhosphorylationKinaseCdc25CEndogenous formPFTK1ResiduesActivation
2008
Activation of brain protein phosphatase‐1I following cardiac arrest and resuscitation involving an interaction with 14‐3‐3γ
Platholi J, Heerdt PM, Tung H, Hemmings HC. Activation of brain protein phosphatase‐1I following cardiac arrest and resuscitation involving an interaction with 14‐3‐3γ. Journal Of Neurochemistry 2008, 105: 2029-2038. PMID: 18284617, PMCID: PMC3872065, DOI: 10.1111/j.1471-4159.2008.05300.x.Peer-Reviewed Original ResearchConceptsGlobal cerebral ischemiaCerebral ischemiaCardiac arrestTransient global cerebral ischemiaTransient cerebral ischemiaPotential therapeutic targetRelevant pig modelIschemic brainNeuroprotective mechanismsControl brainsInhibitory modulatorTherapeutic targetPig modelIschemiaPig brainBrain proteinsMechanism-based approachBrainProtein betaResuscitationEnergy metabolismCritical regulatorArrestVivoActivation
2007
Differential regulation of protein phosphatase-1I by neurabin
Bullock SA, Platholi J, Gjyrezi A, Heerdt PM, Tung HY, Hemmings HC. Differential regulation of protein phosphatase-1I by neurabin. Biochemical And Biophysical Research Communications 2007, 358: 140-144. PMID: 17467665, PMCID: PMC1989152, DOI: 10.1016/j.bbrc.2007.04.076.Peer-Reviewed Original ResearchConceptsProtein phosphatase 1Phosphatase 1Protein phosphatase 1IProtein phosphataseActivation domainMultimeric complexesRegulatory subunitCatalytic subunitSubcellular localizationProtein kinaseSubstrate specificityRegulatory proteinsUnidentified proteinsNeurabinDifferential regulationNovel mechanismProteinSubunitsRegulationMajor formDistinct formsDependent formKinaseActinActivator