2017
Single-lung ventilation and oxidative stress
Heerdt PM, Stowe DF. Single-lung ventilation and oxidative stress. Current Opinion In Anaesthesiology 2017, 30: 42-49. PMID: 27783023, DOI: 10.1097/aco.0000000000000410.Peer-Reviewed Original ResearchConceptsSingle-lung ventilationOxidative stressRe-expanded lungHypoxic pulmonary vasoconstrictionRedistribution of bloodLocal tissue hypoxiaPostoperative disruptionPulmonary vasoconstrictionReperfusion responseAtelectatic lungTissue hypoxiaClinical dataReactive oxygenSystemic effectsOrgan functionLungNitrosative stressVentilationNitrogen speciesVasoconstriction
2007
Nitrosative Stress and Myocardial Sarcoplasmic Endoreticular Calcium Adenosine Triphosphatase Subtype 2a Activity after Lung Resection in Swine
Heerdt PM, Lane P, Pan BY, Schaefer U, Crabtree M, Hong R, Singer AA, Levi R, Park BJ. Nitrosative Stress and Myocardial Sarcoplasmic Endoreticular Calcium Adenosine Triphosphatase Subtype 2a Activity after Lung Resection in Swine. Anesthesiology 2007, 107: 954-962. PMID: 18043064, DOI: 10.1097/01.anes.0000291446.70921.61.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsLungMyocardiumNitric OxideOxidative StressSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesSwineConceptsNitrosative stressForce-frequency relationLung resectionSERCA2a activityAcute oxidative stressOxidative stressPhosphorylation stateSubcellular processesBiochemical basisProtein phospholambanDisease-associated oxidative stressRegulatory protein phospholambanPhospholamban phosphorylationReticular membranesProtein expressionImpaired calcium cyclingPhosphorylationWestern blottingExpressionPerioperative changesUpper lobectomyPhospholamban expressionSham groupAcute eventChronic illness
2006
Systemic oxidative stress associated with lung resection during single lung ventilation
Heerdt PM, Lane PB, Crabtree MJ, Park BJ. Systemic oxidative stress associated with lung resection during single lung ventilation. European Journal Of Cardio-Thoracic Surgery 2006, 30: 568-569. PMID: 16857372, DOI: 10.1016/j.ejcts.2006.05.022.Peer-Reviewed Original Research