2023
Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload
Kheyfets V, Kumar S, Heerdt P, Ichimura K, Brown R, Lucero M, Essafri I, Williams S, Stenmark K, Spiekerkoetter E. Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload. International Journal Of Molecular Sciences 2023, 24: 9746. PMID: 37298696, PMCID: PMC10253685, DOI: 10.3390/ijms24119746.Peer-Reviewed Original ResearchConceptsPressure overloadChronic RV pressure overloadExperimental pulmonary hypertension modelsRV pressure overloadTime pointsPulmonary hypertension modelRV outflow tractTranscriptomic signaturesAcute pressure overloadRight ventricular tissueDifferent time pointsPulmonary embolismHypertension modelSevere PEAcute increaseInitial insultOutflow tractRight ventricleRV apexVentricular tissueControl tissuesRatsSeverityWeeksTissue
2018
Perioperative pulmonary thromboembolism
Ruohoniemi DM, Sista AK, Doany CF, Heerdt PM. Perioperative pulmonary thromboembolism. Current Opinion In Anaesthesiology 2018, 31: 75-82. PMID: 29206697, DOI: 10.1097/aco.0000000000000550.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsCathetersHumansPerioperative PeriodPulmonary EmbolismRisk FactorsThrombolytic TherapyConceptsSubmassive pulmonary emboliCatheter-directed therapyPulmonary emboliSystemic anticoagulationIntervention efficacyMean pulmonary artery pressurePerioperative pulmonary thromboembolismPulmonary artery pressureCurrent treatment optionsWarrants further investigationInadequacy of treatmentArtery pressurePulmonary thromboembolismPostoperative patientsPulmonary embolismRelative contraindicationSurgical patientsAggressive interventionIntraoperative embolizationPerioperative patientsTreatment optionsOptimizing therapyPromising efficacyElevated riskVentricular monitoring