2023
Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome
Singh I, Leitner B, Wang Y, Zhang H, Joseph P, Lutchmansingh D, Gulati M, Possick J, Damsky W, Hwa J, Heerdt P, Chun H. Proteomic profiling demonstrates inflammatory and endotheliopathy signatures associated with impaired cardiopulmonary exercise hemodynamic profile in Post Acute Sequelae of SARS‐CoV‐2 infection (PASC) syndrome. Pulmonary Circulation 2023, 13: e12220. PMID: 37091121, PMCID: PMC10113513, DOI: 10.1002/pul2.12220.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testPASC patientsPost-acute sequelaeAcute sequelaeInfection syndromeUnexplained exertional intoleranceCardiopulmonary exercise testSystemic oxygen deliveryPersistent inflammatory stateVenous blood plasmaExertional intolerancePeak exerciseEndothelial dysfunctionHemodynamic profileInflammatory stateExercise testFibrotic processPathophysiological hallmarkAberrant protein expressionExpression of proteinsOxygen deliveryOxygen extractionProteomic profilingPatientsPhysiologic responses
2019
24 Cardiovascular Physiology Integrative Function
Crystal G, Assaad S, Heerdt P, Desso R, Swenson J, Kolbay P, Kuck K, Decou J. 24 Cardiovascular Physiology Integrative Function. 2019, 473-519. DOI: 10.1016/b978-0-323-48110-6.00024-7.ChaptersBlood flowPerioperative cardiovascular monitoringEnd-systolic pressure-volume relationPulmonary artery catheterMyocardial oxygen demandCoronary blood flowSufficient blood flowCardiac function curveTissue blood flowTissue oxygen deliveryPressure-volume loopsTissue oxygen consumptionCirculatory reflexesPerioperative periodArtery catheterBody tissuesEjection fractionPressure-volume relationCardiac outputCardiac functionMyocardial contractilityMyocardial ischemiaStroke volumePatient managementOxygen delivery