2023
Pulmonary artery wave intensity analysis in a pig model of lung resection
KEAST T, GLASS A, MCCALL P, SHELLEY B, HEERDT P. Pulmonary artery wave intensity analysis in a pig model of lung resection. Journal Of Cardiothoracic And Vascular Anesthesia 2023, 37: 9-10. DOI: 10.1053/j.jvca.2023.08.023.Peer-Reviewed Original ResearchForward compression waveBackward compression waveWave intensity analysisControl subjectsLung resectionPulmonary arteryPig modelSystolic timeCardiovascular MRIInvasive haemodynamic dataPulmonary artery pressureRight ventricular functionProximal pulmonary arteriesMain pulmonary arteryPost-operative patientsRight ventricular contractionWave reflection indicesMann-Whitney testIncreased afterloadLabChart softwareArtery pressureHaemodynamic effectsRV functionUpper lobectomyVentricular function
2009
Postoperative care after pulmonary resection: postanesthesia care unit versus intensive care unit
Pedoto A, Heerdt PM. Postoperative care after pulmonary resection: postanesthesia care unit versus intensive care unit. Current Opinion In Anaesthesiology 2009, 22: 50. PMID: 19295292, DOI: 10.1097/aco.0b013e32831d7b25.Peer-Reviewed Original ResearchConceptsLength of stayElective lung resectionPostanesthesia care unitLung resectionCare unitPostoperative careElective ICU admissionSevere postoperative complicationsHigh-risk patientsImmediate postoperative careNoncardiac thoracic surgeryIntensive care unitPerioperative patient careComplex surgical casesPostoperative areaICU admissionPostoperative complicationsPulmonary resectionPreoperative evaluationAnesthetic techniqueOptimal careLung cancerThoracic surgeryHospital costsSurgical cases
2007
Nitrosative Stress and Myocardial Sarcoplasmic Endoreticular Calcium Adenosine Triphosphatase Subtype 2a Activity after Lung Resection in Swine
Heerdt PM, Lane P, Pan BY, Schaefer U, Crabtree M, Hong R, Singer AA, Levi R, Park BJ. Nitrosative Stress and Myocardial Sarcoplasmic Endoreticular Calcium Adenosine Triphosphatase Subtype 2a Activity after Lung Resection in Swine. Anesthesiology 2007, 107: 954-962. PMID: 18043064, DOI: 10.1097/01.anes.0000291446.70921.61.Peer-Reviewed Original ResearchConceptsNitrosative stressForce-frequency relationLung resectionSERCA2a activityAcute oxidative stressOxidative stressPhosphorylation stateSubcellular processesBiochemical basisProtein phospholambanDisease-associated oxidative stressRegulatory protein phospholambanPhospholamban phosphorylationReticular membranesProtein expressionImpaired calcium cyclingPhosphorylationWestern blottingExpressionPerioperative changesUpper lobectomyPhospholamban expressionSham groupAcute eventChronic illnessInflammation and outcome after general thoracic surgery
Amar D, Zhang H, Park B, Heerdt PM, Fleisher M, Thaler HT. Inflammation and outcome after general thoracic surgery. European Journal Of Cardio-Thoracic Surgery 2007, 32: 431-434. PMID: 17643996, DOI: 10.1016/j.ejcts.2007.06.017.Peer-Reviewed Original ResearchConceptsC-reactive proteinMajor postoperative complicationsPostoperative complicationsIL-6Non-steroidal anti-inflammatory drug useHigh-sensitivity C-reactive proteinAnti-inflammatory drug usePreoperative C-reactive proteinSensitivity C-reactive proteinImportant postoperative complicationPreoperative albumin levelTertiary cancer centerMarkers of inflammationMarkers of outcomePostanesthesia care unitProspective data collectionGeneral thoracic surgeryLung resectionSystemic inflammationAlbumin levelsConsecutive patientsLow albuminCare unitPoor outcomeCancer CenterPulmonary resection in the elderly
Castillo MD, Heerdt PM. Pulmonary resection in the elderly. Current Opinion In Anaesthesiology 2007, 20: 4-9. PMID: 17211159, DOI: 10.1097/aco.0b013e32801271fa.Peer-Reviewed Original ResearchConceptsElderly patientsLung resectionPulmonary resectionOncologic efficacyLung cancerSurgical techniquePreoperative functional statusHealthy elderly patientsLung cancer populationRisk-benefit relationshipInvasive surgical techniquesNeoadjuvant therapyPerioperative morbiditySurgical therapyPerioperative stressPreoperative interventionConventional thoracotomySurgical managementPalliative carePoor prognosisTumor stageCancer populationFunctional statusGeriatric populationPhysiological reserve