2003
Reverse Molecular Remodeling of the Failing Human Heart Following Support with a Left Ventricular Assist Device
Heerdt P, Burkhoff D. Reverse Molecular Remodeling of the Failing Human Heart Following Support with a Left Ventricular Assist Device. Progress In Experimental Cardiology 2003, 7: 19-35. DOI: 10.1007/978-1-4615-0347-7_2.ChaptersLeft ventricular assist deviceVentricular assist deviceAssist deviceEnd-stage heart failureMuscle strip contractionMechanical circulatory supportMyocyte calcium cyclingExcitation-contraction couplingStrip contractionHeart failureLVAD supportCirculatory supportStructural abnormalitiesCalcium cyclingSubcellular abnormalitiesMolecular remodelingHuman heartExpression of genesAbnormalitiesHeartFunctional aspects
2000
Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure
Heerdt P, Holmes J, Cai B, Barbone A, Madigan J, Reiken S, Lee D, Oz M, Marks A, Burkhoff D. Chronic Unloading by Left Ventricular Assist Device Reverses Contractile Dysfunction and Alters Gene Expression in End-Stage Heart Failure. Circulation 2000, 102: 2713-2719. PMID: 11094037, DOI: 10.1161/01.cir.102.22.2713.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlotting, NorthernBlotting, WesternCalcium-Transporting ATPasesFemaleGene Expression RegulationHeart FailureHeart VentriclesHeart-Assist DevicesHumansMaleMiddle AgedMyocardial ContractionRNA, MessengerRyanodine Receptor Calcium Release ChannelSarcolemmaSodium-Hydrogen ExchangersConceptsEnd-stage heart failureLVAD supportHeart failureContractile strengthLVAD implantationSarcoplasmic reticular membranesNegative FFRIntact myocardiumVentricular assist deviceBlot analysisExpression of genesWestern blot analysisContractile dysfunctionSERCA2a proteinLV trabeculaeSubtype 2aChronic unloadingLV tissueAssist deviceContractile forcePatientsAlters gene expressionHigher mRNAReticular membranesRyanodine receptor