2013
NHE Isoform Switching and KChIP2 Upregulation in Aging Porcine Atria
Kant R, Hu Z, Malhotra JK, Krogh-Madsen T, Christini DJ, Heerdt PM, Abbott GW. NHE Isoform Switching and KChIP2 Upregulation in Aging Porcine Atria. PLOS ONE 2013, 8: e82951. PMID: 24376615, PMCID: PMC3871617, DOI: 10.1371/journal.pone.0082951.Peer-Reviewed Original ResearchConceptsAtrial fibrillationMyocyte action potential durationHuman cardiac physiologyCessation of stimulationAction potential durationLarge animal modelSodium-hydrogen exchangerReperfusion arrhythmiasNHE1-specific inhibitorMyocardial responsivenessPharmacological responsivenessPharmacologic efficacyYoung adult pigsAtrial tissuePotential durationTherapeutic targetAnimal modelsCardiac pathologyKChIP2 expressionReal-time qPCRPotential molecular basisTherapeutic agentsCardiac physiologyFemale swineYoung adults
2007
Protein phosphatase‐1I activation in brain following cardiac arrest and resuscitation
Platholi J, Heerdt P, Tung H, Hemmings H. Protein phosphatase‐1I activation in brain following cardiac arrest and resuscitation. The FASEB Journal 2007, 21: a618-a619. DOI: 10.1096/fasebj.21.5.a618-d.Peer-Reviewed Original ResearchProtein phosphatase 1Cerebral ischemiaCellular energy metabolismPig brainApoptotic cell deathTransient global cerebral ischemiaPhosphatase 1Protein regulatorsGlobal cerebral ischemiaPP-1Major proteinsInhibitor 2Cell deathSubunit compositionEnergy metabolismIntact animal modelIonic balanceCardiac arrestAnimal modelsProtective mechanismBrainIschemiaDeathDependent formRegulator