2024
Multimodality Molecular Imaging of Brain Tumor Using Simultaneous [18F]FET-PET/MRSI
Ma C, Han P, Marin T, Zhuo Y, Shih H, Fakhri G. Multimodality Molecular Imaging of Brain Tumor Using Simultaneous [18F]FET-PET/MRSI. 2024, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57108.2024.10656528.Peer-Reviewed Original ResearchList-mode dataMR spectroscopic imagingSpatial resolutionAccurate brain tumor delineationMR physicsIsotropic resolutionBrain tumor delineationImprove treatment planningSpectroscopic imagingTumor delineationSignal-to-noise ratioIntact blood-brain barrierImaging speedAmino acid radiotracerImaging timeMR signalHigher proliferation activityStructural MRTreatment planningBlood-brain barrierMR spectroscopic imaging dataMolecular imaging of brain tumorsTumor involvementTumor infiltrationTumor marginsPET motion correction using subspace-based real-time MR imaging in simultaneous PET/MR
Mounime I, Marin T, Han P, Ouyang J, Gori P, Angelini E, Fakhri G, Ma C. PET motion correction using subspace-based real-time MR imaging in simultaneous PET/MR. 2024, 00: 1-1. DOI: 10.1109/nss/mic/rtsd57108.2024.10657647.Peer-Reviewed Original ResearchOrdered-subset expectation maximizationMotion correctionGated reconstructionsMotion-corrected PET reconstructionsPET eventsCardiac motion phasesMotion correction methodCardiac motionMotion phaseReconstructed dynamic imagesPET reconstructionReal-time MR imagingSimultaneous PET/MRPatient motionSoft tissue contrastDynamic MR image reconstructionReference phaseMitigate artifactsLow-rank propertyMR image reconstructionPositron emission tomographyManifold learning frameworkSpatial resolutionBlurring artifactsImage reconstructionFree‐breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model
Lee W, Han P, Marin T, Mounime I, Eslahi S, Djebra Y, Chi D, Bijari F, Normandin M, Fakhri G, Ma C. Free‐breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model. Magnetic Resonance In Medicine 2024 PMID: 39402014, DOI: 10.1002/mrm.30284.Peer-Reviewed Original ResearchExtracellular volume mappingContrast agent injectionExtracellular volumeGradient echo readoutECV mapsAgent injectionWhole heartEcho readoutExtracellular volume valuesVoxel-by-voxelInversion recovery sequenceSpatial resolutionScan timeImaging timeIn vivo studiesHealthy volunteersModel-based methodsRecovery sequenceInjectionReadoutFree-breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model
Lee W*, Han P*, Marin T, Mounime IBG, Eslahi SV, Djebra Y, Chi D, Bijari FJ, Normandin MD, El Fakhri G, and Ma C. Free-breathing 3D cardiac extracellular volume (ECV) mapping using a linear tangent space alignment (LTSA) model. Magnetic Resonance in Medicine. 2024; doi: 10.1002/mrm.30284.Peer-Reviewed Original ResearchSparsity Constrained Linear Tangent Space Alignment Model (LTSA) for 3d Cardiac Extracellular Volume Mapping
Mounime I, Lee W, Marin T, Han P, Djebra Y, Eslahi S, Gori P, Angelini E, Fakhri G, Ma C. Sparsity Constrained Linear Tangent Space Alignment Model (LTSA) for 3d Cardiac Extracellular Volume Mapping. 2024, 00: 1-5. DOI: 10.1109/isbi56570.2024.10635692.Peer-Reviewed Original ResearchT)-space dataExtracellular volume mappingIntrinsic low-dimensional manifold structureCardiac tissue propertiesImproved image reconstructionLow-dimensional manifold structureExtracellular volumeFast MRI methodSparsity constraintModel-based methodsSuperior performanceSpace alignmentT1 mappingManifold structureImage reconstructionT)-spacePost-contrast T1 mappingTissue propertiesFree breathingConcentration of contrast agentLongitudinal relaxation timeAlignment modelDynamic MR imagingSparsityAlignment matrix
2023
Attenuation correction for PET imaging using conditional denoising diffusion probabilistic model
Dong Y, Jang S, Han P, Johnson K, Ma C, Fakhri G, Li Q, Gong K. Attenuation correction for PET imaging using conditional denoising diffusion probabilistic model. 2023, 00: 1-1. DOI: 10.1109/nssmicrtsd49126.2023.10338188.Peer-Reviewed Original ResearchDiffusion probabilistic modelGenerative adversarial networkConditional encodingAttenuation correctionDenoising diffusion probabilistic modelLow-level featuresProbabilistic modelAttenuation coefficientAdversarial networkExtract featuresPET/MR systemsEncodingPET acquisitionNovel methodDiffusion encodingMagnetic resonanceImagesPET imagingCorrectionMR imagingUNetAttenuationNetworkFeaturesResonanceB1 inhomogeneity‐corrected T1 mapping and quantitative magnetization transfer imaging via simultaneously estimating Bloch‐Siegert shift and magnetization transfer effects
Jang A, Han P, Ma C, Fakhri G, Wang N, Samsonov A, Liu F. B1 inhomogeneity‐corrected T1 mapping and quantitative magnetization transfer imaging via simultaneously estimating Bloch‐Siegert shift and magnetization transfer effects. Magnetic Resonance In Medicine 2023, 90: 1859-1873. PMID: 37427533, PMCID: PMC10528411, DOI: 10.1002/mrm.29778.Peer-Reviewed Original ResearchConceptsBloch-Siegert shiftBloch-SiegertMagnetization transfer effectsMonte Carlo simulationsSpin-lattice relaxationSpin-bath modelMagnetization transferBinary spin-bath modelCarlo simulationsProton fractionOff-resonance irradiationIn vivo brain studiesBloch simulationsPhantom experimentsMagnetizationEstimationTransmitted fieldQuantitative magnetization transferMethod performanceMT effectSignal equationBalanced Steady-State Free Precession and Radial Sampling for Arterial Spin Labeled Perfusion Imaging
Han P, Marin T, Zhuo Y, Ouyang J, Fakhri G, Ma C. Balanced Steady-State Free Precession and Radial Sampling for Arterial Spin Labeled Perfusion Imaging. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/0373.Peer-Reviewed Original ResearchDirect estimation of metabolite maps from undersampled k-space data using linear tangent space alignment
Ma C, Marin T, Han P, Fakhri G. Direct estimation of metabolite maps from undersampled k-space data using linear tangent space alignment. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/0496.Peer-Reviewed Original ResearchArterial spin labeled perfusion imaging with balanced steady-state free precession readout and radial sampling
Han P, Marin T, Zhuo Y, Ouyang J, El Fakhri G, Ma C. Arterial spin labeled perfusion imaging with balanced steady-state free precession readout and radial sampling. Magnetic Resonance Imaging 2023, 102: 126-132. PMID: 37187264, PMCID: PMC10524790, DOI: 10.1016/j.mri.2023.05.005.Peer-Reviewed Original ResearchConceptsOff-resonance effectsBalanced steady-state free precessionPhase-cycling techniqueTemporal SNRBalanced steady-state free precession acquisitionRadial sampling schemeSpoiled gradient-recalled acquisitionRadial samplingCartesian sampling schemeBalanced steady-state free precession readoutK-space dataSampling schemeSpin labelingSteady-state free precessionK-spaceImage readoutBanding artifactsMotion-related artifactsReadoutFree precessionArterial spin labelingImage reconstructionParallel imagingImaging timePerfusion-weighted imaging
2022
Manifold Learning via Linear Tangent Space Alignment (LTSA) for Accelerated Dynamic MRI With Sparse Sampling
Djebra Y, Marin T, Han P, Bloch I, Fakhri G, Ma C. Manifold Learning via Linear Tangent Space Alignment (LTSA) for Accelerated Dynamic MRI With Sparse Sampling. IEEE Transactions On Medical Imaging 2022, 42: 158-169. PMID: 36121938, PMCID: PMC10024645, DOI: 10.1109/tmi.2022.3207774.Peer-Reviewed Original ResearchConceptsSpace alignmentSampled k-space dataState-of-the-art methodsIntrinsic low-dimensional manifold structureNumerical simulation studyLow-dimensional manifold structureState-of-the-artLinear subspace modelSparsity modelModel-based frameworkSubspace modelManifold structureMathematical modelManifold modelSparse samplingImage reconstructionMRI applicationsDynamic magnetic resonance imagingSpatiotemporal signalsSpatial resolutionPerformanceSimulation studyImagesMethodSparsityJoint spectral quantification of MR spectroscopic imaging using linear tangent space alignment‐based manifold learning
Ma C, Han P, Zhuo Y, Djebra Y, Marin T, Fakhri G. Joint spectral quantification of MR spectroscopic imaging using linear tangent space alignment‐based manifold learning. Magnetic Resonance In Medicine 2022, 89: 1297-1313. PMID: 36404676, PMCID: PMC9892363, DOI: 10.1002/mrm.29526.Peer-Reviewed Original ResearchConceptsSubspace-based methodsManifold learningIntrinsic low-dimensional structureGlobal coordinationLearning-based methodsNumerical simulation dataSpatial smoothness constraintSparsity constraintSpace alignmentSubspace modelSmoothness constraintSuperior performanceRoot mean square errorLinear transformationMechanical simulationsLow-dimensionalSquare errorSubspaceExperimental dataSpectroscopic imagingQuantum mechanical simulationsCoordinate alignmentMR spectroscopic imagingSpectral quantificationSimulated dataFree-running Simultaneous 3D Cardiac T1 Mapping and Cine Imaging Using a Linear Tangent Space Alignment Model
Djebra Y, Marin T, Han P, Bloch I, Fakhri G, Ma C. Free-running Simultaneous 3D Cardiac T1 Mapping and Cine Imaging Using a Linear Tangent Space Alignment Model. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/4440.Peer-Reviewed Original ResearchBias-free T1 Mapping via Simultaneously Estimating Bloch-Siegert and Magnetization Transfer Effects
Jang A, Han P, Ma C, Fakhri G, Liu F. Bias-free T1 Mapping via Simultaneously Estimating Bloch-Siegert and Magnetization Transfer Effects. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/0621.Peer-Reviewed Original ResearchUnsupervised arterial spin labeling image superresolution via multiscale generative adversarial network
Cui J, Gong K, Han P, Liu H, Li Q. Unsupervised arterial spin labeling image superresolution via multiscale generative adversarial network. Medical Physics 2022, 49: 2373-2385. PMID: 35048390, DOI: 10.1002/mp.15468.Peer-Reviewed Original ResearchConceptsPeak signal-to-noise ratioStructural similarity indexNearest neighbor interpolationSignal-to-noise ratioTrilinear interpolationNeighbor interpolationAblation studiesB-spline interpolationLow-pass-filterLayer-by-layer trainingLoss termLow resolutionClearer structure boundariesLow signal-to-noise ratioIn vivo datasetsImage superresolutionGAN frameworkAdversarial networkB-spline interpolation methodReduce image noiseWeak labelsPrior informationSimilarity indexDipping methodSimulated data
2021
Free‐breathing 3D cardiac T1 mapping with transmit B1 correction at 3T
Han P, Marin T, Djebra Y, Landes V, Zhuo Y, Fakhri G, Ma C. Free‐breathing 3D cardiac T1 mapping with transmit B1 correction at 3T. Magnetic Resonance In Medicine 2021, 87: 1832-1845. PMID: 34812547, PMCID: PMC8810588, DOI: 10.1002/mrm.29097.Peer-Reviewed Original ResearchConceptsFlip-angle estimationCardiac T<sub>1</sub> mappingGradient echo readoutThrough-plane spatial resolutionImaging timePractical imaging timesFree breathingPhantom studyB1 correctionAccelerated imagingIn-planeT)-spaceMyocardial T<sub>1</sub> valuesSubspace-based methodsSpatial resolutionImaging experimentsAcquisition schemeT)-space dataSubject-specific timeCorrectionModified Look-Locker inversion recoveryLook-Locker inversion recoveryTime of data acquisitionAverage imaging timeInversion-recovery sequenceIn vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker
Mody M, Petibon Y, Han P, Kuruppu D, Ma C, Yokell D, Neelamegam R, Normandin M, Fakhri G, Brownell A. In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker. Scientific Reports 2021, 11: 15897. PMID: 34354107, PMCID: PMC8342610, DOI: 10.1038/s41598-021-94967-y.Peer-Reviewed Original ResearchConceptsFragile X syndromeFragile X mental retardation proteinX syndromeLoss of fragile X mental retardation proteinMGlu5 receptor expressionMetabotropic glutamate subtype 5 receptorsDrug occupancy studiesSignificant group differencesFragile X mental retardationHealthy controlsAnterior cingulateMGluR5 availabilityVisuospatial processingMGlu5 receptorsOlfactory cortexBrain areasGroup differencesRetardation proteinGlutamate signalingImages of maleNeurodevelopmental disordersExcessive glutamate signalingGender-matched controlsDisordersMGluR5
2020
Motion correction for PET data using subspace-based real-time MR imaging in simultaneous PET/MR
Marin T, Djebra Y, Han P, Chemli Y, Bloch I, Fakhri G, Ouyang J, Petibon Y, Ma C. Motion correction for PET data using subspace-based real-time MR imaging in simultaneous PET/MR. Physics In Medicine And Biology 2020, 65: 235022. PMID: 33263317, PMCID: PMC7985095, DOI: 10.1088/1361-6560/abb31d.Peer-Reviewed Original ResearchConceptsPositron emission tomography reconstructionMotion-corrected PET reconstructionsPET reconstructionMotion-corrected PET imagesIrregular respiratory motionMotion fieldMotion correction methodMotion correction approachIrregular motion patternsUndersampled k-space dataImage quality of positron emission tomographyQuality of positron emission tomographyMotion patternsLow-rank characteristicsRespiratory motionContrast-to-noise ratioEstimated motion fieldSurrogate signalsMotion correctionK-space dataImage qualityReal-time MR imagingSimultaneous PET/MRMotion artifact reductionPET/MR scannersAttenuation correction using deep Learning and integrated UTE/multi-echo Dixon sequence: evaluation in amyloid and tau PET imaging
Gong K, Han P, Johnson K, El Fakhri G, Ma C, Li Q. Attenuation correction using deep Learning and integrated UTE/multi-echo Dixon sequence: evaluation in amyloid and tau PET imaging. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 1351-1361. PMID: 33108475, PMCID: PMC8411350, DOI: 10.1007/s00259-020-05061-w.Peer-Reviewed Original ResearchConceptsAttenuation correctionResultsThe Dice coefficientPseudo-CT imagesMR-based AC methodsAccurate ACAC accuracyPET imagingDice coefficientQuantitative accuracyAtlas methodAC methodGradient echoNear verticesTau imagingTau PET imagingAlzheimer's diseaseUltrashortCorrectionTau pathologyRapid acquisitionDeep learning methodsMonitoring of Alzheimer’s diseasePET/MRAmyloidEvaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques
Guehl N, Ramos-Torres K, Linnman C, Moon S, Dhaynaut M, Wilks M, Han P, Ma C, Neelamegam R, Zhou Y, Popko B, Correia J, Reich D, Fakhri G, Herscovitch P, Normandin M, Brugarolas P. Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques. Cerebrovascular And Brain Metabolism Reviews 2020, 41: 1721-1733. PMID: 33090071, PMCID: PMC8221756, DOI: 10.1177/0271678x20963404.Peer-Reviewed Original ResearchConceptsFocal brain injuryMyelin repair therapyContributions of demyelinationDrivers of disabilityImaging demyelinationBrain injuryMeasurements of molecular changesTool's sensitivity to changesLower myelin contentDemyelinating lesionsNeuronal conductionImpaired conductionDemyelinationBrain penetrationGold standardRhesus macaquesInjured areaMultiple sclerosisMolecular changesMyelin sheathNeurological diseasesHigh metabolic stabilityMRI methodsMRIInjury