2021
In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker
Mody M, Petibon Y, Han P, Kuruppu D, Ma C, Yokell D, Neelamegam R, Normandin M, Fakhri G, Brownell A. In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker. Scientific Reports 2021, 11: 15897. PMID: 34354107, PMCID: PMC8342610, DOI: 10.1038/s41598-021-94967-y.Peer-Reviewed Original ResearchConceptsFragile X syndromeFragile X mental retardation proteinX syndromeLoss of fragile X mental retardation proteinMGlu5 receptor expressionMetabotropic glutamate subtype 5 receptorsDrug occupancy studiesSignificant group differencesFragile X mental retardationHealthy controlsAnterior cingulateMGluR5 availabilityVisuospatial processingMGlu5 receptorsOlfactory cortexBrain areasGroup differencesRetardation proteinGlutamate signalingImages of maleNeurodevelopmental disordersExcessive glutamate signalingGender-matched controlsDisordersMGluR5
2015
Whole‐brain perfusion imaging with balanced steady‐state free precession arterial spin labeling
Han P, Ye J, Kim E, Choi S, Park S. Whole‐brain perfusion imaging with balanced steady‐state free precession arterial spin labeling. NMR In Biomedicine 2015, 29: 264-274. PMID: 26676386, DOI: 10.1002/nbm.3463.Peer-Reviewed Original ResearchConceptsSignal-to-noise ratioBalanced steady-state free precessionTotal scan timeCompressive sensingReduced susceptibility artifactsPerfusion imagingWhole-brain perfusion imagingScan timeSusceptibility artifactsPseudo-continuous ASLReadout timeCS approachSteady-state free precessionAcquisition of perfusion imagesSegmentation approachFree precessionBSSFP readoutArterial spin labeling (ASL) perfusionSpatial resolutionImage qualityDistortion-freeReadoutHigh-resolutionTemporal resolutionImagesInvestigation of Inter-Slice Magnetization Transfer Effects as a New Method for MTR Imaging of the Human Brain
Barker J, Han P, Choi S, Bae K, Park S. Investigation of Inter-Slice Magnetization Transfer Effects as a New Method for MTR Imaging of the Human Brain. PLOS ONE 2015, 10: e0117101. PMID: 25664938, PMCID: PMC4321840, DOI: 10.1371/journal.pone.0117101.Peer-Reviewed Original ResearchConceptsBalanced steady-state free precessionFlip angleMagnetization transferMagnetization transfer effectsSteady-state free precessionSaturation pulseModel of MTFree precessionMT-weightedAcquisition parametersMT effectMT ratioDelay timePrecessionMTR imagesHigh SNRInterslicePE stepsMagnetizationFlip