2020
Validating Self‐Reported Unhealthy Alcohol Use With Phosphatidylethanol (PEth) Among Patients With HIV
Eyawo O, Deng Y, Dziura J, Justice AC, McGinnis K, Tate JP, Rodriguez‐Barradas M, Hansen NB, Maisto SA, Marconi VC, O’Connor P, Bryant K, Fiellin DA, Edelman EJ. Validating Self‐Reported Unhealthy Alcohol Use With Phosphatidylethanol (PEth) Among Patients With HIV. Alcohol Clinical And Experimental Research 2020, 44: 2053-2063. PMID: 33460225, PMCID: PMC8856627, DOI: 10.1111/acer.14435.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useSignificant alcohol useHeavy drinking daysAlcohol use disorderTimeline FollowbackAlcohol useSelf-reported alcohol useNumber of drinksClinical trialsRisk drinkingUse disordersDrinking daysBiomarker-based evidenceSample of PWHDrinks/dayMean numberSelf-reported alcohol consumptionMagnitude of associationBlood spot samplesLiver diseasePEth levelsTLFB interviewAlcohol consumptionLogistic regressionPatientsComputerized Cognitive Behavioral Therapy for Substance Use Disorders in a Specialized Primary Care Practice: A Randomized Feasibility Trial to Address the RT Component of SBIRT.
Tetrault JM, Holt SR, Cavallo DA, O'Connor PG, Gordon MA, Corvino JK, Nich C, Carroll KM. Computerized Cognitive Behavioral Therapy for Substance Use Disorders in a Specialized Primary Care Practice: A Randomized Feasibility Trial to Address the RT Component of SBIRT. Journal Of Addiction Medicine 2020, 14: e303-e309. PMID: 32371660, DOI: 10.1097/adm.0000000000000663.Peer-Reviewed Original ResearchConceptsSubstance use disordersComputerized cognitive behavioral therapySubstance useCognitive behavioral therapySelf-reported substance useUse disordersTechnology-based treatmentsPrimary care settingSubstance use outcomesIntegrated addictions treatmentTechnology-based interventionsBehavioral therapyPrimary care practicesOverall positive outcomeSUD interventionsBrief interventionUnhealthy alcohol useDays abstinentPositive outcomesUse outcomesCare settingsAlcohol useStandard careAddiction treatmentTreatment settings
2019
Integrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Deng Y, Fiellin LE, O'Connor PG, Bedimo R, Gibert CL, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Tate JP, Justice AC, Bryant KJ, Fiellin DA. Integrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial. The Lancet HIV 2019, 6: e509-e517. PMID: 31109915, PMCID: PMC7161741, DOI: 10.1016/s2352-3018(19)30076-1.Peer-Reviewed Original ResearchConceptsAlcohol use disorderWeek 24Use disordersAlcohol treatmentAdverse eventsNumber of drinksTreatment medicationsPhysician managementAlcohol abuseMental Disorders-IV criteriaAlcohol-related careFormal alcohol treatmentKey exclusion criteriaTimeline followback methodMotivational enhancement therapyTreat populationHIV clinicHIV outcomesPrimary outcomeSpecialty referralsMean ageUS National InstitutesWeek 4Medical conditionsExclusion criteria
2016
Protocol for three parallel multi-site stepped care effectiveness studies for unhealthy alcohol use in HIV-positive patients
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Fiellin LE, O'Connor PG, Bedimo R, Gibert C, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Justice AC, Bryant KJ, Fiellin DA. Protocol for three parallel multi-site stepped care effectiveness studies for unhealthy alcohol use in HIV-positive patients. Contemporary Clinical Trials 2016, 52: 80-90. PMID: 27876616, PMCID: PMC5253227, DOI: 10.1016/j.cct.2016.11.008.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useAlcohol use disorderHIV-positive patientsMotivational enhancement therapyAlcohol useWeek 12Risk drinkingWeek 4Effective evidence-based treatmentsInfectious disease clinicHIV-positive individualsModerate alcohol useEvidence-based treatmentsParticipants meeting criteriaImplementation of interventionsVACS IndexHIV careSecondary outcomesCare trialsDisease clinicHIV morbidityPrimary outcomeAlcohol pharmacotherapyInitial treatmentLiver disease
2015
An analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate
Gueorguieva R, Wu R, Tsai WM, O’Connor P, Fucito L, Zhang H, O’Malley S. An analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate. European Neuropsychopharmacology 2015, 25: 1586-1599. PMID: 26141511, PMCID: PMC4600651, DOI: 10.1016/j.euroneuro.2015.06.006.Peer-Reviewed Original ResearchConceptsAcamprosate effectHeavy drinkingShort abstinenceEnhanced treatment responseMonths of treatmentSubgroup of patientsBody mass indexDrug plasma levelsIdentification of subgroupsBetter prognosisLower BMIMass indexPlasma levelsGlutamatergic hyperactivityTreatment responseAcamprosateCOMBINE StudyPrior treatmentLarger studyConsecutive daysAbstinencePretreatment abstinenceTreatment effectsCognitive inefficiencySubgroups
2013
Managing Substance Dependence as a Chronic Disease: Is the Glass Half Full or Half Empty?
O’Connor P. Managing Substance Dependence as a Chronic Disease: Is the Glass Half Full or Half Empty? JAMA 2013, 310: 1132-1134. PMID: 24045739, DOI: 10.1001/jama.2013.277610.Peer-Reviewed Original Research
2012
Developing and Implementing a Multispecialty Graduate Medical Education Curriculum on Screening, Brief Intervention, and Referral to Treatment (SBIRT)
Tetrault JM, Green ML, Martino S, Thung SF, Degutis LC, Ryan SA, Martel S, Pantalon MV, Bernstein SL, O'Connor P, Fiellin DA, D'Onofrio G. Developing and Implementing a Multispecialty Graduate Medical Education Curriculum on Screening, Brief Intervention, and Referral to Treatment (SBIRT). Substance Use & Addiction Journal 2012, 33: 168-181. PMID: 22489589, DOI: 10.1080/08897077.2011.640220.Peer-Reviewed Original ResearchConceptsBrief interventionInternal medicineEmergency medicineMean satisfaction scoreMultiple residency programsStandardized patient sessionSBIRT curriculumClinical practicePediatric programsSBIRTSatisfaction scoresClinical encountersPatient sessionsPediatric residentsProject facultyTraining Web siteStandardized patientsReferralGynecologyObstetricsNumber of residentsResidency programsSatisfaction surveyGraduate medical education curriculumFaculty supervisionA Brief Intervention Reduces Hazardous and Harmful Drinking in Emergency Department Patients
D'Onofrio G, Fiellin DA, Pantalon MV, Chawarski MC, Owens PH, Degutis LC, Busch SH, Bernstein SL, O'Connor PG. A Brief Intervention Reduces Hazardous and Harmful Drinking in Emergency Department Patients. Annals Of Emergency Medicine 2012, 60: 181-192. PMID: 22459448, PMCID: PMC3811141, DOI: 10.1016/j.annemergmed.2012.02.006.Peer-Reviewed Original ResearchConceptsBrief Negotiation InterviewStandard careEmergency department patientsBrief interventionAlcohol consumptionDepartment patientsHarmful drinkersDrinking outcomesHarmful drinkingAssessment groupStandard care groupAdult ED patientsNegative health behaviorsSecondary outcomesPrimary outcomeED patientsCare groupED settingTelephone boosterBooster groupBinge episodesHealth behaviorsPatientsAlcohol useCare
2011
Medications for unhealthy alcohol use: across the spectrum.
O'Malley SS, O'Connor PG. Medications for unhealthy alcohol use: across the spectrum. Alcohol Research 2011, 33: 300-12. PMID: 23580015, PMCID: PMC3860540.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useSpecialty careCare settingsAlcohol useAdvent of pharmacotherapyPrimary care providersPrimary care settingSpectrum of careHealth care settingsPrimary careCare providersHazardous drinkersEarly interventionExcessive drinkingCareAlcohol problemsTreatmentMedicationsPharmacotherapyPatientsCliniciansPrevalenceSettingDrinkers
2007
Smoking Status as a Clinical Indicator for Alcohol Misuse in US Adults
McKee SA, Falba T, O’Malley S, Sindelar J, O’Connor P. Smoking Status as a Clinical Indicator for Alcohol Misuse in US Adults. JAMA Internal Medicine 2007, 167: 716-721. PMID: 17420431, PMCID: PMC2869385, DOI: 10.1001/archinte.167.7.716.Peer-Reviewed Original ResearchConceptsClinical care guidelinesSmoking statusPositive predictive valueClinical indicatorsAlcohol misuseUS adultsPositive likelihood ratioCurrent smokingCare guidelinesOdds ratioAlcohol diagnosisAssociated Disabilities Interview Schedule-IVPredictive valueHazardous drinkingPrimary care settingAlcohol-related diagnosesConfidence intervalsAlcohol use disorderNational Epidemiological SurveyAlcohol use diagnosisHazardous drinking behaviorLikelihood ratioOccasional smokersPrimary careDaily smokersBrief interventions for problem drinking: another piece of the puzzle.
O'Connor PG. Brief interventions for problem drinking: another piece of the puzzle. Annals Of Internal Medicine 2007, 146: 223-5. PMID: 17283352, DOI: 10.7326/0003-4819-146-3-200702060-00012.Peer-Reviewed Original Research
2005
The prevalence and impact of alcohol problems in major depression: A systematic review
Sullivan LE, Fiellin DA, O’Connor P. The prevalence and impact of alcohol problems in major depression: A systematic review. The American Journal Of Medicine 2005, 118: 330-341. PMID: 15808128, DOI: 10.1016/j.amjmed.2005.01.007.Peer-Reviewed Original ResearchConceptsHealth care utilizationLifetime alcohol problemsCare utilizationDepression outcomesAlcohol problemsMajor depressionGeneral populationAlcohol abuseAlcohol dependenceHealth care utilization outcomesPrimary care outpatient settingCochrane Controlled Trials RegistryControlled Trials RegistrySocial functioningPsychiatric inpatient settingsCourse of depressionEnglish-language studiesSevere alcohol problemsTrials RegistryUtilization outcomesDepression courseOutpatient settingPrimary careDeath riskWorse outcomesDevelopment and Implementation of an Emergency Practitioner–Performed Brief Intervention for Hazardous and Harmful Drinkers in the Emergency Department
D'Onofrio G, Pantalon MV, Degutis LC, Fiellin DA, O'Connor PG. Development and Implementation of an Emergency Practitioner–Performed Brief Intervention for Hazardous and Harmful Drinkers in the Emergency Department. Academic Emergency Medicine 2005, 12: 249-256. PMID: 15741590, PMCID: PMC1414059, DOI: 10.1197/j.aem.2004.10.021.Peer-Reviewed Original ResearchConceptsBrief Negotiation InterviewEmergency practitionersEmergency departmentBrief interventionClinical careEfficacy of BIRoutine clinical careMean durationPatient outcomesHarmful drinkersStandardized patient scenariosClinical practicePatient scenariosDrinkersMean numberInterventionTraining sessionsCarePilot testingDepartmentSessionsHospitalTrials
2003
Initial and Maintenance Naltrexone Treatment for Alcohol Dependence Using Primary Care vs Specialty Care: A Nested Sequence of 3 Randomized Trials
O'Malley SS, Rounsaville BJ, Farren C, Namkoong K, Wu R, Robinson J, O'Connor PG. Initial and Maintenance Naltrexone Treatment for Alcohol Dependence Using Primary Care vs Specialty Care: A Nested Sequence of 3 Randomized Trials. JAMA Internal Medicine 2003, 163: 1695-1704. PMID: 12885685, DOI: 10.1001/archinte.163.14.1695.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlanine TransaminaseAlcoholismAspartate AminotransferasesCognitive Behavioral TherapyCombined Modality TherapyConnecticutFemaleGamma-GlutamyltransferaseHumansMaleMedicineMiddle AgedNaltrexoneNarcotic AntagonistsPatient CompliancePatient ParticipationPrimary Health CareSpecializationTimeTreatment OutcomeConceptsPrimary care managementCognitive behavior therapyPlacebo-controlled studyAlcohol dependenceNaltrexone treatmentPersistent heavy drinkingPrimary care treatmentWeeks of treatmentMaintenance of responseMaintenance of improvementCBT armCBT patientsPlacebo groupNaltrexone maintenanceRandomized trialsCare treatmentPrimary careSpecialty carePCM patientsDays abstinentNaltrexoneInitial courseCare managementCBT respondersPatientsMeasuring Alcohol Consumption Among Older Adults: A Comparison of Available Methods
Reid MC, Tinetti ME, O'Connor PG, Kosten TR, Concato J. Measuring Alcohol Consumption Among Older Adults: A Comparison of Available Methods. American Journal On Addictions 2003, 12: 211-219. PMID: 12851017, DOI: 10.1111/j.1521-0391.2003.tb00649.x.Peer-Reviewed Original ResearchConceptsAlcohol exposureVA primary care clinicsOlder adultsCommunity-dwelling Medicare beneficiariesQuantity-frequency questionsPrimary care clinicsAlcohol Use Disorders Identification TestPercentage of participantsDisorders Identification TestCare clinicsAlcohol historyCurrent drinkersOlder veteransMedicare beneficiariesAlcohol consumptionElderly adultsOlder personsLevel of agreementAlcohol useIdentification TestKappa valuesAdultsAlcohol measuresConcordanceExposureManagement of Drug and Alcohol Withdrawal
Kosten TR, O'Connor PG. Management of Drug and Alcohol Withdrawal. New England Journal Of Medicine 2003, 348: 1786-1795. PMID: 12724485, DOI: 10.1056/nejmra020617.Peer-Reviewed Original Research
2002
The Physician's Role in Caring for Patients with Substance use Disorders: Implications for Medical Education and Training
Fiellin DA, Butler R, D'Onofrio G, Brown RL, O'Connor PG. The Physician's Role in Caring for Patients with Substance use Disorders: Implications for Medical Education and Training. Substance Use & Addiction Journal 2002, 23: 207-222. PMID: 23580996, DOI: 10.1080/08897070209511516.Peer-Reviewed Educational Materials
2000
Outpatient management of patients with alcohol problems.
Fiellin DA, Reid MC, O'Connor PG. Outpatient management of patients with alcohol problems. Annals Of Internal Medicine 2000, 133: 815-27. PMID: 11085845, DOI: 10.7326/0003-4819-133-10-200011210-00015.Peer-Reviewed Original ResearchScreening for Alcohol Problems in Primary Care: A Systematic Review
Fiellin DA, Reid MC, O'Connor PG. Screening for Alcohol Problems in Primary Care: A Systematic Review. JAMA Internal Medicine 2000, 160: 1977-1989. PMID: 10888972, DOI: 10.1001/archinte.160.13.1977.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestPrimary careAlcohol problemsFormal screening instrumentsAlcohol abuseHarmful drinkingScreening instrumentQuantity-frequency questionsPrimary care physiciansSearch of MEDLINEDisorders Identification TestCAGE questionsCare physiciansClinical subgroupsClinical measuresCriterion standardDiagnostic test researchSystematic reviewPatient spectrumDiagnostic testsMethodological standardsCareIdentification TestWorkup biasMethodological limitationsNaltrexone-Induced Nausea in Patients Treated for Alcohol Dependence: Clinical Predictors and Evidence for Opioid-Mediated Effects
O'Malley S, Krishnan-Sarin S, Farren C, O'Connor P. Naltrexone-Induced Nausea in Patients Treated for Alcohol Dependence: Clinical Predictors and Evidence for Opioid-Mediated Effects. Journal Of Clinical Psychopharmacology 2000, 20: 69-76. PMID: 10653211, DOI: 10.1097/00004714-200002000-00012.Peer-Reviewed Original ResearchConceptsRisk of nauseaEndogenous opioid systemIntensity of drinkingSevere nauseaOpioid systemAlcohol useLight drinkersMost alcoholic patientsWeeks of naltrexoneOpen-label trialLong-term alcohol usePoor medication compliancePretreatment patient characteristicsLogistic regression analysisAlcohol-dependent subjectsDays of abstinenceDuration of abstinenceSignificant nauseaPatient characteristicsClinical predictorsEndogenous opioidsMedication complianceAlcoholic patientsNaltrexone doseRisk factors